Search Results - "Schrump, David"

Cytotoxicity Mediated by Histone Deacetylase Inhibitors in Cancer Cells: Mechanisms and Potential Clinical Implications by Schrump, David S

“…Aberrant expression of epigenetic regulators of gene expression contributes to initiation and progression of cancer. During recent years, considerable research…”
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Ionic immune suppression within the tumour microenvironment limits T cell effector function by Eil, Robert, Vodnala, Suman K., Clever, David, Klebanoff, Christopher A., Sukumar, Madhusudhanan, Pan, Jenny H., Palmer, Douglas C., Gros, Alena, Yamamoto, Tori N., Patel, Shashank J., Guittard, Geoffrey C., Yu, Zhiya, Carbonaro, Valentina, Okkenhaug, Klaus, Schrump, David S., Linehan, W. Marston, Roychoudhuri, Rahul, Restifo, Nicholas P.

“…Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo …”
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Molecular Subtypes of Primary SCLC Tumors and Their Associations With Neuroendocrine and Therapeutic Markers by Qu, Song, Fetsch, Patricia, Thomas, Anish, Pommier, Yves, Schrump, David S, Miettinen, Markku M, Chen, Haobin

“…A new molecular subtype classification was recently proposed for SCLC. It is necessary to validate it in primary SCLC tumors by immunohistochemical (IHC)…”
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Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy by Sukumar, Madhusudhanan, Liu, Jie, Mehta, Gautam U., Patel, Shashank J., Roychoudhuri, Rahul, Crompton, Joseph G., Klebanoff, Christopher A., Ji, Yun, Li, Peng, Yu, Zhiya, Whitehill, Greg D., Clever, David, Eil, Robert L., Palmer, Douglas C., Mitra, Suman, Rao, Mahadev, Keyvanfar, Keyvan, Schrump, David S., Wang, Ena, Marincola, Francesco M., Gattinoni, Luca, Leonard, Warren J., Muranski, Pawel, Finkel, Toren, Restifo, Nicholas P.

“…Long-term survival and antitumor immunity of adoptively transferred CD8+ T cells is dependent on their metabolic fitness, but approaches to isolate therapeutic…”
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Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy by Hassan, Raffit, Morrow, Betsy, Thomas, Anish, Walsh, Tom, Lee, Ming K., Gulsuner, Suleyman, Gadiraju, Meghana, Panou, Vasiliki, Gao, Shaojian, Mian, Idrees, Khan, Javed, Raffeld, Mark, Patel, Snehal, Xi, Liqiang, Wei, Jun S., Hesdorffer, Mary, Zhang, Jingli, Calzone, Kathleen, Desai, Arpita, Padiernos, Emerson, Alewine, Christine, Schrump, David S., Steinberg, Seth M., Kindler, Hedy L., King, Mary-Claire, Churpek, Jane E.

“…Survival from malignant mesothelioma, particularly pleural mesothelioma, is very poor. For patients with breast, ovarian, or prostate cancers, overall survival…”
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A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries by Miller, Andrew C, Rosati, Shannon F, Suffredini, Anthony F, Schrump, David S

“…Abstract Objective The incidence of thoracic injuries resulting from cardiopulmonary resuscitation (CPR) is not well characterized. We describe a case in which…”
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Role of Local Ablative Therapy in Patients with Oligometastatic and Oligoprogressive Non-Small Cell Lung Cancer by Kim, Chul, Hoang, Chuong D, Kesarwala, Aparna H, Schrump, David S, Guha, Udayan, Rajan, Arun

“…Because of an improved understanding of lung cancer biology and improvement in systemic treatment, an oligometastatic state in which metastatic disease is…”
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Commentary: Keeping the target painted for precision cancer therapy by Schrump, David S., Hoang, Chuong D.

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Normal mesothelial cell lines newly derived from human pleural biopsy explants by Pruett, Nathanael, Singh, Anand, Shankar, Ahjeetha, Schrump, David S, Hoang, Chuong D

“…Mesothelial cells are arranged as a monolayer on covering membranes that invest surfaces of body cavities like the pleura and peritoneum. Primary human…”
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A spectrum of severe familial liver disorders associate with telomerase mutations by Calado, Rodrigo T, Regal, Joshua A, Kleiner, David E, Schrump, David S, Peterson, Nathan R, Pons, Veronica, Chanock, Stephen J, Lansdorp, Peter M, Young, Neal S

“…Telomerase is an enzyme specialized in maintaining telomere lengths in highly proliferative cells. Loss-of-function mutations cause critical telomere…”
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Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells by Xi, Sichuan, Yang, Maocheng, Tao, Yongguang, Xu, Hong, Shan, Jigui, Inchauste, Suzanne, Zhang, Mary, Mercedes, Leandro, Hong, Julie A, Rao, Mahadev, Schrump, David S

“…Limited information is available regarding mechanisms by which miRNAs contribute to pulmonary carcinogenesis. The present study was undertaken to examine…”
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CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells by Bu, Xiangning, Kato, Jiro, Hong, Julie A, Merino, Maria J, Schrump, David S, Lund, Frances E, Moss, Joel

“…CD38 overexpression was found in human lung cancer cell lines and tissues. CD38 deletion inhibited oncogenesis in vitro and in vivo. It is expected that…”
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Circulating Tumor DNA: Solid Data from Liquid Biopsies by Schrump, David S., M.D., M.B.A

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MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis by Singh, Anand, Bhattacharyya, Nisan, Srivastava, Abhishek, Pruett, Nathanael, Ripley, R. Taylor, Schrump, David S., Hoang, Chuong D.

“…Malignant pleural mesothelioma (MPM) is an incurable, aggressive neoplasm with distinctive features, including preservation of wild-type p53, irrespective of…”
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Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma by Inaguma, Shingo, Lasota, Jerzy, Wang, Zengfeng, Czapiewski, Piotr, Langfort, Renata, Rys, Janusz, Szpor, Joanna, Waloszczyk, Piotr, Okoń, Krzysztof, Biernat, Wojciech, Ikeda, Hiroshi, Schrump, David S., Hassan, Raffit, Miettinen, Markku

“…Diffuse malignant mesothelioma of the pleura is a highly aggressive tumor typically associated with short survival. ALCAM (CD166), a type I transmembrane…”
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CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness by Inaguma, Shingo, Lasota, Jerzy, Czapiewski, Piotr, Langfort, Renata, Rys, Janusz, Szpor, Joanna, Waloszczyk, Piotr, Okoń, Krzysztof, Biernat, Wojciech, Schrump, David S, Hassan, Raffit, Kasai, Kenji, Miettinen, Markku, Ikeda, Hiroshi

“…Diffuse malignant mesothelioma of the pleura (MPM) is a highly aggressive tumour that typically is associated with short survival. CD70 and CD27 belong to the…”
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BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation by Chen, Haobin, Gesumaria, Lisa, Park, Young-Kwon, Oliver, Trudy G, Singer, Dinah S, Ge, Kai, Schrump, David S

“…Small-cell lung cancer (SCLC) is a recalcitrant malignancy that urgently needs new therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and…”
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The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas by Xiao, Zuoxiang, Jiang, Qun, Willette-Brown, Jami, Xi, Sichuan, Zhu, Feng, Burkett, Sandra, Back, Timothy, Song, Na-Young, Datla, Mahesh, Sun, Zhonghe, Goldszmid, Romina, Lin, Fanching, Cohoon, Travis, Pike, Kristen, Wu, Xiaolin, Schrump, David S., Wong, Kwok-Kin, Young, Howard A., Trinchieri, Giorgio, Wiltrout, Robert H., Hu, Yinling

“…Here, we report that kinase-dead IKKα knockin mice develop spontaneous lung squamous cell carcinomas (SCCs) associated with IKKα downregulation and marked…”
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Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer by Lo, Winifred, Parkhurst, Maria, Robbins, Paul F, Tran, Eric, Lu, Yong-Chen, Jia, Li, Gartner, Jared J, Pasetto, Anna, Deniger, Drew, Malekzadeh, Parisa, Shelton, Thomas E, Prickett, Todd, Ray, Satyajit, Kivitz, Scott, Paria, Biman C, Kriley, Isaac, Schrump, David S, Rosenberg, Steven A

“…Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting…”
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A unique gene signature predicting recurrence-free survival in stage IA lung adenocarcinoma by Carr, Shamus R., Wang, Haitao, Hudlikar, Rasika, Lu, Xiaofan, Zhang, Mary R., Hoang, Chuong D., Yan, Fangrong, Schrump, David S.

“…Resected stage IA lung adenocarcinoma has a reported 5-year recurrence-free survival of 63% to 81%. A unique gene signature stratifying patients with…”
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