Search Results - "Schroeter, Eric H."

Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina by Godinho, Leanne, Mumm, Jeff S, Williams, Philip R, Schroeter, Eric H, Koerber, Amy, Park, Seung W, Leach, Steven D, Wong, Rachel O L

“…Cellular mechanisms underlying the precision by which neurons target their synaptic partners have largely been determined based on the study of projection…”
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A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis by Schroeter, Eric H., Ma. Xenia G. Ilagan, Brunkan, Anne L., Hecimovic, Silva, Li, Yue-ming, Xu, Min, Lewis, Huw D., Saxena, Meera T., De Strooper, Bart, Coonrod, Archie, Tomita, Taisuke, Iwatsubo, Takeshi, Moore, Chad L., Goate, Alison, Wolfe, Michael S., Shearman, Mark, Kopan, Raphael

“…Notch receptors and the amyloid precursor protein are type I membrane proteins that are proteolytically cleaved within their transmembrane domains by a…”
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Expression of cytosolic peroxiredoxins in Plasmodium berghei ookinetes is regulated by environmental factors in the mosquito bloodmeal by Turturice, Benjamin A, Lamm, Michael A, Tasch, James J, Zalewski, Angelika, Kooistra, Rachel, Schroeter, Eric H, Sharma, Sapna, Kawazu, Shin-Ichiro, Kanzok, Stefan M

“…The Plasmodium ookinete develops over several hours in the bloodmeal of its mosquito vector where it is exposed to exogenous stresses, including cytotoxic…”
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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 by Kopan, Raphael, Huppert, Stacey S, Le, Anh, Schroeter, Eric H, Mumm, Jeffrey S, Saxena, Meera T, Milner, Laurie A

“…The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several…”
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Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization by Vooijs, Marc, Schroeter, Eric H., Pan, Yonghua, Blandford, Mary, Kopan, Raphael

“…Intramembrane cleaving proteases such as site 2 protease, γ-secretase, and signal peptide peptidase hydrolyze peptide bonds within the transmembrane domain…”
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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain by Kopan, Raphael, Schroeter, Eric H, Kisslinger, Jeffrey A

“…Notch proteins are ligand-activated transmembrane receptors involved in cell-fate selection throughout development. No known enzymatic activity is contained…”
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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain by De Strooper, Bart, Kopan, Raphael, Annaert, Wim, Cupers, Philippe, Saftig, Paul, Craessaerts, Katleen, Mumm, Jeffrey S, Schroeter, Eric H, Schrijvers, Vincent, Wolfe, Michael S, Ray, William J, Goate, Alison

“…Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions during development, requires ligand-induced cleavage of Notch…”
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A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1 by Mumm, Jeffrey S, Schroeter, Eric H, Saxena, Meera T, Griesemer, Adam, Tian, Xiaolin, Pan, D.J, Ray, William J, Kopan, Raphael

“…γ-secretase-like proteolysis at site 3 (S3), within the transmembrane domain, releases the N otch i ntra c ellular d omain (NICD) and activates CSL-mediated…”
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Signalling downstream of activated mammalian Notch by Jarriault, Sophie, Brou, Christel, Logeat, Frédérique, Schroeter, Eric H, Kopan, Raphael, Israel, Alain

“…Notch belongs to a family of transmembrane proteins that are widely conserved from flies to vertebrates and are thought to be involved in cell-fate decisions…”
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Cone Survival Despite Rod Degeneration in XOPS-mCFP Transgenic Zebrafish by Morris, Ann C, Schroeter, Eric H, Bilotta, Joseph, Wong, Rachel O. L, Fadool, James M

“…In animal models of retinitis pigmentosa, rod photoreceptor degeneration eventually leads to loss of cone photoreceptors. The purpose of this study was to…”
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Murine Notch Homologs (N1–4) Undergo Presenilin-dependent Proteolysis by Saxena, Meera T., Schroeter, Eric H., Mumm, Jeffrey S., Kopan, Raphael

“…Oncogenic forms of Notch1, Notch2, and Notch4 appear to mimic signaling intermediates of Notch1 and suggest that the role of proteolysis in Notch signaling has…”
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γ-Secretase Inhibitors Repress Thymocyte Development by Hadland, Brandon K., Manley, Nancy R., Su, Dong-ming, Longmore, Gregory D., Moore, Chad L., Wolfe, Michael S., Schroeter, Eric H., Kopan, Raphael

“…A major therapeutic target in the search for a cure to the devastating Alzheimer's disease is γ-secretase. This activity resides in a multiprotein enzyme…”
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Signal Transduction by Activated mNotch: Importance of Proteolytic Processing and its Regulation by the Extracellular Domain by Kopan, Raphael, Schroeter, Eric H., Weintraub, Harold, Nye, Jeffrey S.

“…Previous studies imply that the intracellular domain of Notch 1 must translocate to the nucleus for its activity. In this study, we demonstrate that a mNotch 1…”
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In vivo development of retinal ON-bipolar cell axonal terminals visualized in nyx::MYFP transgenic zebrafish by Schroeter, Eric H, Wong, Rachel O L, Gregg, Ronald G

“…Axonal differentiation of retinal bipolar cells has largely been studied by comparing the morphology of these interneurons in fixed tissue at different ages…”
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Laminar circuit formation in the vertebrate retina by Mumm, Jeff S, Godinho, Leanne, Morgan, Josh L, Oakley, Dennis M, Schroeter, Eric H, Wong, Rachel O L

“…Neuronal function depends on the accurate wiring between pre- and postsynaptic cells. Determining the mechanisms underlying precision in neuronal connectivity…”
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erratum: Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 by Huppert, Stacey S, Le, Anh, Schroeter, Eric H, Mumm, Jeffrey S, Saxena, Meera T, Milner, Laurie A, Kopan, Raphael

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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch by Ray, W J, Yao, M, Mumm, J, Schroeter, E H, Saftig, P, Wolfe, M, Selkoe, D J, Kopan, R, Goate, A M

“…Presenilin-1 (PS1), a polytopic membrane protein primarily localized to the endoplasmic reticulum, is required for efficient proteolysis of both Notch and…”
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APP and notch proteolysis by γ-secretase requires that these substrates complex with PS1 by Ray, William J., Brunkan, Anne, Schroeter, Eric H., Kopan, Raphael, Goate, Alison M.

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The next step in notch processing and its relevance to APP biology by Kopan, Raphael, Mumm, Jeffrey S., Schroeter, Eric H., Saxena, Meera T., Ray, William J., Goate, Alison M.

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Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch by William J. Ray, Min Yao, Jeff Mumm, Eric H. Schroeter, Paul Saftig, Michael Wolfe, Dennis J. Selkoe, Raphael Kopan, Alison M. Goate

“…Presenilin-1 (PS1), a polytopic membrane protein primarily localized to the endoplasmic reticulum, is required for efficient proteolysis of both Notch and…”
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