Search Results - "Schroedter, Mathias"
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Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis
Published in Shock (Augusta, Ga.) (01-12-2018)“…PURPOSE:Adrenomedullin (ADM) is an important regulator of endothelial barrier function during sepsis. Administration of a murine antibody targeted against the…”
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Journal Article -
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Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure
Published in Journal of intensive care (31-03-2016)“…Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical…”
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Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates
Published in Toxicology and applied pharmacology (15-04-2019)“…Adrenomedullin (ADM) is a vasoactive peptide in sepsis. The non-neutralizing ADM-binding antibody Adrecizumab improved outcome in animal models of systemic…”
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Journal Article