Search Results - "Schroeder, Simon"

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19 by Hoffmann, Markus, Schroeder, Simon, Kleine-Weber, Hannah, Müller, Marcel A, Drosten, Christian, Pöhlmann, Stefan

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor by Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan

“…The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health…”
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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals by Gassen, Nils C., Papies, Jan, Bajaj, Thomas, Emanuel, Jackson, Dethloff, Frederik, Chua, Robert Lorenz, Trimpert, Jakob, Heinemann, Nicolas, Niemeyer, Christine, Weege, Friderike, Hönzke, Katja, Aschman, Tom, Heinz, Daniel E., Weckmann, Katja, Ebert, Tim, Zellner, Andreas, Lennarz, Martina, Wyler, Emanuel, Schroeder, Simon, Richter, Anja, Niemeyer, Daniela, Hoffmann, Karen, Meyer, Thomas F., Heppner, Frank L., Corman, Victor M., Landthaler, Markus, Hocke, Andreas C., Morkel, Markus, Osterrieder, Nikolaus, Conrad, Christian, Eils, Roland, Radbruch, Helena, Giavalisco, Patrick, Drosten, Christian, Müller, Marcel A.

“…Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and…”
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Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics by Schroeder, Simon, Pott, Fabian, Niemeyer, Daniela, Veith, Talitha, Richter, Anja, Muth, Doreen, Goffinet, Christine, Müller, Marcel A, Drosten, Christian

“…The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the…”
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Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus by Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Prokscha, Alexander, Naim, Hassan Y., Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan, Hoffmann, Markus

“…Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) causes a severe respiratory disease in humans. The MERS-CoV spike (S) glycoprotein mediates…”
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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression by Niemeyer, Daniela, Stenzel, Saskia, Veith, Talitha, Schroeder, Simon, Friedmann, Kirstin, Weege, Friderike, Trimpert, Jakob, Heinze, Julian, Richter, Anja, Jansen, Jenny, Emanuel, Jackson, Kazmierski, Julia, Pott, Fabian, Jeworowski, Lara M, Olmer, Ruth, Jaboreck, Mark-Christian, Tenner, Beate, Papies, Jan, Walper, Felix, Schmidt, Marie L, Heinemann, Nicolas, Möncke-Buchner, Elisabeth, Baumgardt, Morris, Hoffmann, Karen, Widera, Marek, Thao, Tran Thi Nhu, Balázs, Anita, Schulze, Jessica, Mache, Christin, Jones, Terry C, Morkel, Markus, Ciesek, Sandra, Hanitsch, Leif G, Mall, Marcus A, Hocke, Andreas C, Thiel, Volker, Osterrieder, Klaus, Wolff, Thorsten, Martin, Ulrich, Corman, Victor M, Müller, Marcel A, Goffinet, Christine, Drosten, Christian

“…Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more…”
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Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells by Papies, Jan, Emanuel, Jackson, Heinemann, Nicolas, Kulić, Žarko, Schroeder, Simon, Tenner, Beate, Lehner, Martin D, Seifert, Georg, Müller, Marcel A

“…Treatment options for COVID-19 are currently limited. Drugs reducing both viral loads and SARS-CoV-2-induced inflammatory responses would be ideal candidates…”
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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5 by Schroeder, Simon, Mache, Christin, Kleine-Weber, Hannah, Corman, Victor M., Muth, Doreen, Richter, Anja, Fatykhova, Diana, Memish, Ziad A., Stanifer, Megan L., Boulant, Steeve, Gultom, Mitra, Dijkman, Ronald, Eggeling, Stephan, Hocke, Andreas, Hippenstiel, Stefan, Thiel, Volker, Pöhlmann, Stefan, Wolff, Thorsten, Müller, Marcel A., Drosten, Christian

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa. Virus-induced pneumonia in humans…”
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Transgene expression in the genome of Middle East respiratory syndrome coronavirus based on a novel reverse genetics system utilizing Red-mediated recombination cloning by Muth, Doreen, Meyer, Benjamin, Niemeyer, Daniela, Schroeder, Simon, Osterrieder, Nikolaus, Müller, Marcel Alexander, Drosten, Christian

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is a high-priority pathogen in pandemic preparedness research. Reverse genetics systems are a valuable…”
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Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection by Mhlekude, Baxolele, Postmus, Dylan, Stenzel, Saskia, Weiner, 3rd, January, Jansen, Jenny, Zapatero-Belinchón, Francisco J, Olmer, Ruth, Richter, Anja, Heinze, Julian, Heinemann, Nicolas, Mühlemann, Barbara, Schroeder, Simon, Jones, Terry C, Müller, Marcel A, Drosten, Christian, Pich, Andreas, Thiel, Volker, Martin, Ulrich, Niemeyer, Daniela, Gerold, Gisa, Beule, Dieter, Goffinet, Christine

“…Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection…”
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Corrigendum: Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs ® 7630 in SARS-CoV-2-Infected Human Lung Cells by Papies, Jan, Emanuel, Jackson, Heinemann, Nicolas, Kulić, Žarko, Schroeder, Simon, Tenner, Beate, Lehner, Martin D, Seifert, Georg, Müller, Marcel A

“…[This corrects the article DOI: 10.3389/fphar.2021.757666.]…”
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Detection of distinct MERS-Coronavirus strains in dromedary camels from Kenya, 2017 by Kiambi, Stella, Corman, Victor M., Sitawa, Rina, Githinji, Jane, Ngoci, James, Ozomata, Abdullahi S., Gardner, Emma, von Dobschuetz, Sophie, Morzaria, Subhash, Kimutai, Joshua, Schroeder, Simon, Njagi, Obadiah, Simpkin, Piers, Rugalema, Gabriel, Tadesse, Zelalem, Lubroth, Juan, Makonnen, Yilma, Drosten, Christian, Müller, Marcel A., Fasina, Folorunso O.

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Relationship between effective lens position and axial position of a thick intraocular lens by Schröder, Simon, Langenbucher, Achim

“…To discuss the impact of intraocular lens-(IOL)-power, IOL-thickness, IOL-shape, corneal power and effective lens position (ELP) on the distance between the…”
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A Survey on Semi-, Self- and Unsupervised Learning for Image Classification by Schmarje, Lars, Santarossa, Monty, Schroder, Simon-Martin, Koch, Reinhard

“…While deep learning strategies achieve outstanding results in computer vision tasks, one issue remains: The current strategies rely heavily on a huge amount of…”
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Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform by Thi Nhu Thao, Tran, Labroussaa, Fabien, Ebert, Nadine, V’kovski, Philip, Stalder, Hanspeter, Portmann, Jasmine, Kelly, Jenna, Steiner, Silvio, Holwerda, Melle, Kratzel, Annika, Gultom, Mitra, Schmied, Kimberly, Laloli, Laura, Hüsser, Linda, Wider, Manon, Pfaender, Stephanie, Hirt, Dagny, Cippà, Valentina, Crespo-Pomar, Silvia, Schröder, Simon, Muth, Doreen, Niemeyer, Daniela, Corman, Victor M., Müller, Marcel A., Drosten, Christian, Dijkman, Ronald, Jores, Joerg, Thiel, Volker

“…Reverse genetics has been an indispensable tool to gain insights into viral pathogenesis and vaccine development. The genomes of large RNA viruses, such as…”
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A flux conserving meshfree method for conservation laws by Suchde, Pratik, Kuhnert, Jörg, Schröder, Simon, Klar, Axel

“…Summary Lack of conservation has been the biggest drawback in meshfree generalized finite difference methods (GFDMs). In this paper, we present a novel…”
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MorphoCluster: Efficient Annotation of Plankton Images by Clustering by Schröder, Simon-Martin, Kiko, Rainer, Koch, Reinhard

“…In this work, we present MorphoCluster, a software tool for data-driven, fast, and accurate annotation of large image data sets. While already having surpassed…”
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Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles by Schröder, Simon, Langenbucher, Achim, Schrecker, Jens

“…To compare corneal tomography measurements (elevation and pachymetry) as made by two corneal tomographers: Pentacam AXL and CASIA 2. The devices were used in a…”
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Optimal Dataset Sizes for Constant Optimization in Published Theoretical Optical Formulae by Langenbucher, Achim, Schwemm, Michael, Eppig, Timo, Schröder, Simon, Cayless, Alan, Szentmáry, Nóra

“…Purpose: To determine the optimal number of data points required for optimization of formulae for classical lens power calculation. Methods: A large dataset of…”
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On the Chromatic Dispersion of Hydrophobic and Hydrophilic Intraocular Lenses by Eppig, Timo, Rawer, Antonia, Hoffmann, Peter, Langenbucher, Achim, Schröder, Simon

“…There is a high variation of chromatic dispersion with contemporary intraocular lens (IOL) materials. It is well known that chromatic aberration limits the…”
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