Search Results - "Schroeder, Scott D."

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model by Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.

“…People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication…”
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Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873 by Kato, Darryl, Choy, Regina Wai-Yan, Canales, Eda, Dick, Ryan A., Lake, April D., Shapiro, Nathan D., Chin, Elbert, Li, Jiayao, Zhang, Jennifer R., Wu, Qiaoyin, Saito, Roland D., Metobo, Sammy, Aktoudianakis, Evangelos, Schroeder, Scott D., Yang, Zheng-Yu, Glatt, Dylan M., Balsitis, Scott, Gamelin, Lindsay, Yu, Mei, Cheng, Guofeng, Delaney, William E., Link, John O.

“…Chronic hepatitis B (CHB) virus infection afflicts hundreds of millions of people and causes nearly one million deaths annually. The high levels of circulating…”
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Targeting methanopterin biosynthesis to inhibit methanogenesis by Dumitru, R, Palencia, H, Schroeder, S.D, DeMontigny, B.A, Takacs, J.M, Rasche, M.E, Miner, J.L, Ragsdale, S.W

“…This paper describes the design, synthesis, and successful employment of inhibitors of 4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate (RFA-P) synthase,…”
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539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans by Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C

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Controlling Mode Selectivity in Palladium-Catalyzed Bisdiene Carbocyclizations:  Optimizing for Cyclization-Trapping over Cycloisomerization by Takacs, James M, Schroeder, Scott D, Han, Jianxin, Gifford, Meg, Jiang, Xun-tian, Saleh, Twana, Vayalakkada, Suresh, Yap, Amy H

“…Screening combinations of five catalyst precursors with 13 phosphorus ligands identified cyclization catalysts that favor carbocyclization-trapping with…”
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Clinical targeting of HIV capsid protein with a long-acting small molecule by Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., Cihlar, Tomas

“…Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis 1…”
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Directed Intermolecular Association by Complementary Molecular Edges in 6-Methoxycoumarin by Baures, Paul W, Rush, Jeremy R, Schroeder, Scott D, Beatty, Alicia M

“…The design of complementary hydrogen bonding interactions between molecules is often used in crystal engineering and other molecular recognition research…”
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1625-P: GS-4571, an Oral Small Molecule GLP-1R Agonist, Improves Glucose Tolerance and Suppresses Food Intake in Obese Diabetic Cynomolgus Monkeys by Vogel, Jen, Seung, Minji, Marchand, Bruno, Bhangre, Neeraja, Mukherjee, Jit, Ammann, Stephen E, Armstrong, Megan, Brizgys, Gediminas, Chin, Elbert, Chou, Chien-Hung, Cottell, Jeromy, Schroeder, Scott D, Thomas-Tran, Rhiannon, Yang, Zheng-Yu, Peters, Michael, Budas, Grant, Mitchell, Michael L, Chojnacka, Maja, Jermain, Scott, Hung, Joey, Kulkarni, Supriya, Yue, Qin, Lin, David W, Miranda, Diego A

“…The Glucagon-like peptide 1 receptor (GLP-1R) is a class B1 G-protein-coupled receptor (GPCR) that is widely expressed and helps mediate insulin secretion,…”
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Targeting Methanopterin Biosynthesis ToInhibitMethanogenesis by Dumitru, Razvan, Palencia, Hector, Schroeder, Scott D., DeMontigny, Bree A., Takacs, James M., Rasche, Madeline E., Miner, Jess L., Ragsdale, Stephen W.

“…ABSTRACT This paper describes the design, synthesis, and successful employment of inhibitors of 4-(β- d -ribofuranosyl)aminobenzene-5′-phosphate (RFA-P)…”
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