Search Results - "Schrock, Morgan S"

TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways by Singh, Karnika, Han, Chunhua, Fleming, Jessica L., Becker, Aline P., McElroy, Joseph, Cui, Tiantian, Johnson, Benjamin, Kumar, Ashok, Sebastian, Ebin, Showalter, Christian A., Schrock, Morgan S., Summers, Matthew K., Becker, Valesio, Tong, Zhen-yue, Meng, Xiaomei, Manring, Heather R., Venere, Monica, Bell, Erica H., Robe, Pierre A., Grosu, A. L., Haque, S. Jaharul, Chakravarti, Arnab

“…GBM (Glioblastoma) is the most lethal CNS (Central nervous system) tumor in adults, which inevitably develops resistance to standard treatments leading to…”
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Fhit loss‐associated initiation and progression of neoplasia in vitro by Karras, Jenna R., Schrock, Morgan S., Batar, Bahadir, Zhang, Jie, La Perle, Krista, Druck, Teresa, Huebner, Kay

“…The FHIT gene, encompassing an active common fragile site, FRA3B, is frequently silenced in preneoplasia and cancer, through gene rearrangement or methylation…”
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Exome‐wide single‐base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse by Paisie, Carolyn A., Schrock, Morgan S., Karras, Jenna R., Zhang, Jie, Miuma, Satoshi, Ouda, Iman M., Waters, Catherine E., Saldivar, Joshua C., Druck, Teresa, Huebner, Kay

“…Loss of expression of Fhit, a tumor suppressor and genome caretaker, occurs in preneoplastic lesions during development of many human cancers. Furthermore,…”
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APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis by Schrock, Morgan S., Stromberg, Benjamin R., Scarberry, Luke, Summers, Matthew K.

“…The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating…”
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A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells by Hanel, Walter, Lata, Pushpa, Youssef, Youssef, Tran, Ha, Tsyba, Liudmyla, Sehgal, Lalit, Blaser, Bradley W, Huszar, Dennis, Helmig-Mason, JoBeth, Zhang, Liwen, Schrock, Morgan S, Summers, Matthew K, Chan, Wing Keung, Prouty, Alexander, Mundy-Bosse, Bethany L, Chen-Kiang, Selina, Danilov, Alexey V, Maddocks, Kami, Baiocchi, Robert A, Alinari, Lapo

“…Abstract Background Mantle cell lymphoma (MCL) is a rare, highly heterogeneous type of B-cell non-Hodgkin’s lymphoma. The sumoylation pathway is known to be…”
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WWOX: A fragile tumor suppressor by Schrock, Morgan S, Huebner, Kay

“…WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3–q24.1, spanning chromosomal fragile site FRA16D, encodes the 46 kDa Wwox…”
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MKLP2 functions in early mitosis to ensure proper chromosome congression by Schrock, Morgan S, Scarberry, Luke, Stromberg, Benjamin R, Sears, Claire, Torres, Adrian E, Tallman, David, Krupinski, Lucas, Chakravarti, Arnab, Summers, Matthew K

“…Mitotic kinesin-like protein 2 (MKLP2; also known as KIF20A) is a motor protein with a well-established function in promoting cytokinesis. However, our results…”
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Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination by Park, Dongju, Gharghabi, Mehdi, Schrock, Morgan S., Plow, Rebecca, Druck, Teresa, Yungvirt, Charles, Aldaz, C. Marcelo, Huebner, Kay

“…Down regulation of Wwox protein expression occurs in many cancers, contributing to insensitivity to ionizing radiation (IR) and platinum drug treatments…”
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Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers by Karras, Jenna R, Schrock, Morgan S, Batar, Bahadir, Huebner, Kay

“…FHIT, located at FRA3B, is one of the most commonly deleted genes in human cancers, and loss of FHIT protein is one of the earliest events in cancer…”
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LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance by Roberts, Melyssa S, Sahni, Jennifer M, Schrock, Morgan S, Piemonte, Katrina M, Weber-Bonk, Kristen L, Seachrist, Darcie D, Avril, Stefanie, Anstine, Lindsey J, Singh, Salendra, Sizemore, Steven T, Varadan, Vinay, Summers, Matthew K, Keri, Ruth A

“…A significant therapeutic challenge for patients with cancer is resistance to chemotherapies such as taxanes. Overexpression of LIN9, a transcriptional…”
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The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma by Tallman, Miranda M., Zalenski, Abigail A., Deighen, Amanda M., Schrock, Morgan S., Mortach, Sherry, Grubb, Treg M., Kastury, Preetham S., Huntoon, Kristin, Summers, Matthew K., Venere, Monica

“…Glioblastoma (GBM) is an incurable brain tumor with inevitable recurrence. This is in part due to a highly malignant cancer stem cell (CSC) subpopulation of…”
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The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted FHIT alleles by Volinia, Stefano, Druck, Teresa, Paisie, Carolyn A, Schrock, Morgan S, Huebner, Kay

“…The gene is located at the fragile FRA3B locus where activation by carcinogen-induced and endogenous replication stress causes deletions even in normal cells…”
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Improving Localized Radiotherapy for Glioblastoma via Small Molecule Inhibition of KIF11 by Tallman, Miranda M, Zalenski, Abigail A, Stabl, Ian, Schrock, Morgan S, Kollin, Luke, de Jong, Eliane, De, Kuntal, Grubb, Treg M, Summers, Matthew K, Venere, Monica

“…Glioblastoma, IDH-wild type (GBM) is the most common and lethal malignant primary brain tumor. Standard of care includes surgery, radiotherapy, and…”
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FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis by Waters, Catherine E, Saldivar, Joshua C, Amin, Zaynab A, Schrock, Morgan S, Huebner, Kay

“…APOBEC cytidine deaminase activity is a major source of hypermutation in cancer. But previous studies have shown that the TC context signature of these enzymes…”
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Establishment and characterization of two novel patient‐derived lines from canine high‐grade glioma by Schrock, Morgan S., Zalenski, Abigail A., Tallman, Miranda M., Kollin, Luke, Bratasz, Anna, Weeks, Griffin, Miller, Margaret A., Sweeney, Courtney N., Pluhar, G. Elizabeth, Olin, Michael R., Kisseberth, William C., Bentley, R. Timothy, Dickinson, Peter J., York, Daniel, Webb, Amy, Wang, Xu, Moore, Sarah, Venere, Monica, Summers, Matthew K.

“…High‐grade glioma is an aggressive cancer that occurs naturally in pet dogs. Canine high‐grade glioma (cHGG) is treated with radiation, chemotherapy or…”
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Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch by Schrock, Morgan S., Karras, Jenna R., Guggenbiller, Matthew J., Druck, Teresa, Batar, Bahadir, Huebner, Kay

“…Expression of Fhit and Wwox protein is frequently lost or reduced in many human cancers. In this report, we provide data that further characterizes the…”
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Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation by Sun, Jin, Shen, Rulong, Schrock, Morgan S., Liu, James, Pan, Xueliang, Quimby, Donald, Zanesi, Nicola, Druck, Teresa, Fong, Louise Y., Huebner, Kay

“…Inadequate dietary Zn consumption increases susceptibility to esophageal and other cancers in humans and model organisms. Since Zn supplementation can prevent…”
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Cover Image by Schrock, Morgan S., Zalenski, Abigail A., Tallman, Miranda M., Kollin, Luke, Bratasz, Anna, Weeks, Griffin, Miller, Margaret A., Sweeney, Courtney N., Pluhar, G. Elizabeth, Olin, Michael R., Kisseberth, William C., Bentley, R. Timothy, Dickinson, Peter J., York, Daniel, Webb, Amy, Wang, Xu, Moore, Sarah, Venere, Monica, Summers, Matthew K.

“…The cover image is based on the Original Article Establishment and characterization of two novel patient‐derived lines from canine high‐grade glioma by Morgan…”
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Wwox Deficiency in Human Cancers: Role in Treatment Resistance by Schrock, Morgan S

“…WWOX gene deletions occur in a variety of human cancer types, and reduced Wwox protein expression can be detected early during cancer development. In this…”
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