Search Results - "Schrimpf, Michael"

Avian behaviour changes in response to human activity during the COVID-19 lockdown in the United Kingdom by Warrington, Miyako H, Schrimpf, Michael B, Des Brisay, Paulson, Taylor, Michelle E, Koper, Nicola

“…Human activities may impact animal habitat and resource use, potentially influencing contemporary evolution in animals. In the United Kingdom, COVID-19…”
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Antiviral Drug Discovery for the Treatment of COVID-19 Infections by Ng, Teresa I, Correia, Ivan, Seagal, Jane, DeGoey, David A, Schrimpf, Michael R, Hardee, David J, Noey, Elizabeth L, Kati, Warren M

“…The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recently emerged human…”
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Regional breeding bird assessment of the Antarctic Peninsula by Schrimpf, Michael B., Che-Castaldo, Christian, Lynch, Heather J.

“…Conservation of seabirds in remote polar regions requires accurate information on the location of breeding sites, which is often limited by logistical…”
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Reduced human activity during COVID-19 alters avian land use across North America by Schrimpf, Michael B, Des Brisay, Paulson G, Johnston, Alison, Smith, Adam C, Sánchez-Jasso, Jessica, Robinson, Barry G, Warrington, Miyako H, Mahony, Nancy A, Horn, Andrew G, Strimas-Mackey, Matthew, Fahrig, Lenore, Koper, Nicola

“…The COVID-19 pandemic resulted in extraordinary declines in human mobility, which, in turn, may affect wildlife. Using records of more than 4.3 million birds…”
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Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro by Kovar, Peter, Richardson, Paul L, Korepanova, Alla, Afanador, Gustavo A, Stojkovic, Vladimir, Li, Tao, Schrimpf, Michael R, Ng, Teresa I, Degoey, David A, Gopalakrishnan, Sujatha M, Chen, Jun

“…The SARS-CoV-2 main protease (Mpro) is essential for viral replication because it is responsible for the processing of most of the non-structural proteins…”
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Metabolism and Disposition of a Novel Selective α 7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis by Liu, Hong, Stresser, David M, Michmerhuizen, Melissa J, Li, Xiaofeng, Othman, Ahmed A, Reed, Aimee D, Schrimpf, Michael R, Sydor, Jens, Lee, Anthony J

“…Mass balance, metabolism, and excretion of ABT-126, an 7 neuronal acetylcholine receptor agonist, were characterized in healthy male subjects ( = 4) after a…”
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Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis by Liu, Hong, Stresser, David M, Michmerhuizen, Melissa J, Li, Xiaofeng, Othman, Ahmed A, Reed, Aimee D, Schrimpf, Michael R, Sydor, Jens, Lee, Anthony J

“…Mass balance, metabolism, and excretion of ABT-126, an α7 neuronal acetylcholine receptor agonist, were characterized in healthy male subjects (n = 4) after a…”
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Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis by Scanio, Marc J. C, Searle, Xenia B, Liu, Bo, Koenig, John R, Altenbach, Robert, Gfesser, Gregory A, Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M, Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Jia, Ying, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing

“…Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or…”
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Phytoplankton Communities in Green Bay, Lake Michigan after Invasion by Dreissenid Mussels: Increased Dominance by Cyanobacteria by De Stasio, Bart, Schrimpf, Michael, Cornwell, Brendan

“…Biological invasions of aquatic systems disrupt ecological communities, and cause major changes in diversity and ecosystem function. The Laurentian Great Lakes…”
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Trade-offs in prey quality and quantity revealed through the behavioral compensation of breeding seabirds by Schrimpf, Michael B., Parrish, Julia K., Pearson, Scott F.

“…Many productive ocean ecosystems are also highly variable, resulting in complex trophic interactions. We analyzed interannual patterns in the diet of a…”
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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore by Schrimpf, Michael R., Sippy, Kevin B., Briggs, Clark A., Anderson, David J., Li, Tao, Ji, Jianguo, Frost, Jennifer M., Surowy, Carol S., Bunnelle, William H., Gopalakrishnan, Murali, Meyer, Michael D.

“…The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the α7 neuronal nicotinic receptor (Ki=56nM). SAR…”
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Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain by Beebe, Xenia, Yeung, Clinton M., Darczak, Daria, Shekhar, Shashank, Vortherms, Timothy A., Miller, Loan, Milicic, Ivan, Swensen, Andrew M., Zhu, Chang Z., Banfor, Patricia, Wetter, Jill M., Marsh, Kennan C., Jarvis, Michael F., Scott, Victoria E., Schrimpf, Michael R., Lee, Chih-Hung

“…A novel series of N-type calcium channel inhibitors have been discovered. Optimization of potency and HT-ADME properties provides 4-aminocyclopentapyrrolidines…”
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A Model Approach for Estimating Colony Size, Trends, and Habitat Associations of Burrow-Nesting Seabirds by Pearson, Scott F., Hodum, Peter J., Good, Thomas P., Schrimpf, Michael, Knapp, Shannon M.

“…We present a prototype monitoring strategy for estimating the density and number of occupied burrows of burrow-nesting seabirds. We use data and management…”
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SAR of alpha 7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore by Schrimpf, Michael R, Sippy, Kevin B, Briggs, Clark A, Anderson, David J, Li, Tao, Ji, Jianguo, Frost, Jennifer M, Surowy, Carol S, Bunnelle, William H, Gopalakrishnan, Murali, Meyer, Michael D

“…The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the alpha 7 neuronal nicotinic receptor (Ki = 56 nM)…”
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Synthesis and evaluation of new radioligands [11 C]A-833834 and [11 C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors by Horti, Andrew G, Ravert, Hayden T, Gao, Yongjun, Holt, Daniel P, Bunnelle, William H, Schrimpf, Michael R, Li, Tao, Ji, Jianguo, Valentine, Heather, Scheffel, Ursula, Kuwabara, Hiroto, Wong, Dean F, Dannals, Robert F

“…Abstract Introduction α7-nicotinic acetylcholine receptor (α7-nAChR) is one of the major neuronal nAChR subtypes. α7-nAChR is involved in variety of neuronal…”
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Structure−Activity Studies and Analgesic Efficacy of N-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors by Bunnelle, William H, Daanen, Jerome F, Ryther, Keith B, Schrimpf, Michael R, Dart, Michael J, Gelain, Arianna, Meyer, Michael D, Frost, Jennifer M, Anderson, David J, Buckley, Michael, Curzon, Peter, Cao, Ying-Jun, Puttfarcken, Pamela, Searle, Xenia, Ji, Jianguo, Putman, C. Brent, Surowy, Carol, Toma, Lucio, Barlocco, Daniela

“…A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of…”
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Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors by SIPPY, Kevin B, ANDERSON, David J, BUNNELLE, William H, HUTCHINS, Charles W, SCHRIMPF, Michael R

“…Several N-pyridin-3-yl spirobicyclic diamines, designed as conformationally restricted analogs of tebanicline (ABT-594), were synthesized as novel ligands for…”
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Design of ligands for the nicotinic acetylcholine receptors: the quest for selectivity by Bunnelle, William H, Dart, Michael J, Schrimpf, Michael R

“…In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important targets for drug discovery. The therapeutic potential of nicotinic…”
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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists by Ji, Jianguo, Schrimpf, Michael R, Sippy, Kevin B, Bunnelle, William H, Li, Tao, Anderson, David J, Faltynek, Connie, Surowy, Carol S, Dyhring, Tino, Ahring, Philip K, Meyer, Michael D

“…A series of novel, potent neuronal nicotinic acetylcholine receptor (nAChR) ligands derived from 3,6-diazabicyclo[3.2.0]heptane have been synthesized and…”
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Syntheses and structure–activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands by Li, Tao, Bunnelle, William H., Ryther, Keith B., Anderson, David J., Malysz, John, Helfrich, Rosalind, Grønlien, Jens H., Håkerud, Monika, Peters, Dan, Schrimpf, Michael R., Gopalakrishnan, Murali, Ji, Jianguo

“…A series of biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes were synthesized as potent and selective α7 NNR agonists. Among them, compound 18e shows a α7…”
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