Search Results - "Schreiber, Valérie"

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art by De Vos, Mike, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribose) polymerase (PARP) catalyzed poly(ADP-ribosyl)ation is one of the earliest post-translational modification of proteins detectable at sites of…”
Get full text

Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3 by Beck, Carole, Robert, Isabelle, Reina-San-Martin, Bernardo, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent…”
Get full text

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation by Bai, Péter, Cantó, Carles, Oudart, Hugues, Brunyánszki, Attila, Cen, Yana, Thomas, Charles, Yamamoto, Hiroyasu, Huber, Aline, Kiss, Borbála, Houtkooper, Riekelt H., Schoonjans, Kristina, Schreiber, Valérie, Sauve, Anthony A., Menissier-de Murcia, Josiane, Auwerx, Johan

“…SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD+…”
Get full text

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells by Mortusewicz, Oliver, Amé, Jean-Christophe, Schreiber, Valérie, Leonhardt, Heinrich

“…Genome integrity is constantly threatened by DNA lesions arising from numerous exogenous and endogenous sources. Survival depends on immediate recognition of…”
Get full text

PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage by Das, Benu Brata, Huang, Shar-yin N, Murai, Junko, Rehman, Ishita, Amé, Jean-Christophe, Sengupta, Souvik, Das, Subhendu K, Majumdar, Papiya, Zhang, Hongliang, Biard, Denis, Majumder, Hemanta K, Schreiber, Valérie, Pommier, Yves

“…Poly(ADP-ribose) polymerases (PARP) attach poly(ADP-ribose) (PAR) chains to various proteins including themselves and chromatin. Topoisomerase I (Top1)…”
Get full text

Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production by Thirunavukkarasu, Shyamala, Ahmed, Mushtaq, Rosa, Bruce A, Boothby, Mark, Cho, Sung Hoon, Rangel-Moreno, Javier, Mbandi, Stanley K, Schreiber, Valérie, Gupta, Ananya, Zuniga, Joaquin, Mitreva, Makedonka, Kaushal, Deepak, Scriba, Thomas J, Khader, Shabaana A

“…The ADP ribosyltransferases (PARPs 1-17) regulate diverse cellular processes, including DNA damage repair. PARPs are classified on the basis of their ability…”
Get full text

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression by Boehler, Christian, Gauthier, Laurent R, Mortusewicz, Oliver, Biard, Denis S, Saliou, Jean-Michel, Bresson, Anne, Sanglier-Cianferani, Sarah, Smith, Susan, Schreiber, Valérie, Boussin, François, Dantzer, Françoise

“…The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of…”
Get full text

New readers and interpretations of poly(ADP-ribosyl)ation by Kalisch, Thomas, Amé, Jean-Christophe, Dantzer, Françoise, Schreiber, Valérie

“…Poly(ADP-ribosyl)ation (PARylation), a protein post-translational modification that was originally connected to the DNA damage response, is now known to engage…”
Get full text

Poly(ADP-ribose): novel functions for an old molecule by Schreiber, Valérie, Dantzer, Françoise, Ame, Jean-Christophe, de Murcia, Gilbert

“…The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique…”
Get full text

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation by Stilmann, Michael, Hinz, Michael, Arslan, Seda Çöl, Zimmer, Anja, Schreiber, Valérie, Scheidereit, Claus

“…Upon genotoxic stresses, cells activate IκB kinases (IKKs) and the transcription factor NF-κB to modulate apoptotic responses. The SUMO-1 ligase PIASy and the…”
Get full text

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms by Mortusewicz, Oliver, Fouquerel, Elise, Amé, Jean-Christophe, Leonhardt, Heinrich, Schreiber, Valérie

“…Post-translational poly(ADP-ribosyl)ation has diverse essential functions in the cellular response to DNA damage as it contributes to avid DNA damage detection…”
Get full text

Toward specific functions of poly(ADP-ribose) polymerase-2 by Yélamos, José, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribose) polymerase-2 (PARP-2) belongs to a family of enzymes that catalyze poly(ADP-ribosyl)ation of proteins. PARP-1 and PARP-2 are so far the only…”
Get full text

Radiation-induced mitotic catastrophe in PARG-deficient cells by Amé, Jean-Christophe, Fouquerel, Elise, Gauthier, Laurent R, Biard, Denis, Boussin, François D, Dantzer, Françoise, de Murcia, Gilbert, Schreiber, Valérie

“…Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and…”
Get full text

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways by Beck, Carole, Boehler, Christian, Guirouilh Barbat, Josée, Bonnet, Marie-Elise, Illuzzi, Giuditta, Ronde, Philippe, Gauthier, Laurent R., Magroun, Najat, Rajendran, Anbazhagan, Lopez, Bernard S., Scully, Ralph, Boussin, François D., Schreiber, Valérie, Dantzer, Françoise

“…The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous…”
Get full text

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure by Bai, Péter, Canto, Carles, Brunyánszki, Attila, Huber, Aline, Szántó, Magdolna, Cen, Yana, Yamamoto, Hiroyasu, Houten, Sander M., Kiss, Borbala, Oudart, Hugues, Gergely, Pál, Menissier-de Murcia, Josiane, Schreiber, Valérie, Sauve, Anthony A., Auwerx, Johan

“…SIRT1 is a NAD+-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here, we tested whether…”
Get full text

The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series by Hakmé, Antoinette, Wong, Heng-Kuan, Dantzer, Françoise, Schreiber, Valérie

“…Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and…”
Get full text

PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis by Karicheva, Olga, Rodriguez-Vargas, José Manuel, Wadier, Nadège, Martin-Hernandez, Kathline, Vauchelles, Romain, Magroun, Najat, Tissier, Agnès, Schreiber, Valérie, Dantzer, Françoise

“…Several members of the Poly(ADP-ribose) polymerase (PARP) family are essential regulators of genome integrity, actively prospected as drug targets for cancer…”
Get full text

PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers by Beck, Carole, Rodriguez-Vargas, José Manuel, Boehler, Christian, Robert, Isabelle, Heyer, Vincent, Hanini, Najat, Gauthier, Laurent R., Tissier, Agnès, Schreiber, Valérie, Elofsson, Mikael, Reina San Martin, Bernardo, Dantzer, Françoise

“…PARP3 has been shown to be a key driver of TGFβ-induced epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells, emerging as an…”
Get full text

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock by Martin, Nadine, Schwamborn, Klaus, Schreiber, Valérie, Werner, Andreas, Guillier, Christelle, Zhang, Xiang-Dong, Bischof, Oliver, Seeler, Jacob-S, Dejean, Anne

“…Heat shock and other environmental stresses rapidly induce transcriptional responses subject to regulation by a variety of post‐translational modifications…”
Get full text

The role of poly(ADP-ribosyl)ation in epigenetic events by Quénet, Delphine, El Ramy, Rosy, Schreiber, Valérie, Dantzer, Françoise

“…Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and higher order…”
Get full text