Search Results - "Schreiber, L"

The gut microbiota–brain axis in behaviour and brain disorders by Morais, Livia H., Schreiber, Henry L., Mazmanian, Sarkis K.

“…In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal hosts to regulate the development and function of the immune,…”
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Chemical probes and drug leads from advances in synthetic planning and methodology by Gerry, Christopher J., Schreiber, Stuart L.

“…Strategies such as diversity-oriented synthesis aim to explore novel areas of chemical space efficiently by populating small-molecule screening libraries with…”
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Persister cancer cells: Iron addiction and vulnerability to ferroptosis by Rodriguez, Raphaël, Schreiber, Stuart L., Conrad, Marcus

“…Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to…”
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Direct control of mitochondrial function by mTOR by Ramanathan, Arvind, Schreiber, Stuart L

“…mTOR is a central regulator of cellular growth and metabolism. Using metabolic profiling and numerous small-molecule probes, we investigated whether mTOR…”
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Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds by Wang, Qiu, Schreiber, Stuart L

“…A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen…”
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Regulation of Ferroptotic Cancer Cell Death by GPX4 by Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.

“…Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12…”
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Sterically Shielded Heptamethine Cyanine Dyes for Bioconjugation and High Performance Near‐Infrared Fluorescence Imaging by Li, Dong‐Hao, Schreiber, Cynthia L., Smith, Bradley D.

“…The near‐infrared window of fluorescent heptamethine cyanine dyes greatly facilitates biological imaging because there is deep penetration of the light and…”
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition by Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T.

“…Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4. Reservoir of resistance…”
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Disorders of compulsivity: a common bias towards learning habits by Voon, V, Derbyshire, K, Rück, C, Irvine, M A, Worbe, Y, Enander, J, Schreiber, L R N, Gillan, C, Fineberg, N A, Sahakian, B J, Robbins, T W, Harrison, N A, Wood, J, Daw, N D, Dayan, P, Grant, J E, Bullmore, E T

“…Why do we repeat choices that we know are bad for us? Decision making is characterized by the parallel engagement of two distinct systems, goal-directed and…”
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Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery by Schreiber, Stuart L.

“…Modern drug discovery often involves screening small molecules for their ability to bind to a preselected protein target. Target-oriented syntheses of these…”
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Towards the Optimal Screening Collection: A Synthesis Strategy by Nielsen, Thomas E, Schreiber, Stuart L

“…The development of effective small-molecule probes and drugs entails at least three stages: 1) a discovery phase, often requiring the synthesis and screening…”
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The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods by Wagner, Bridget K, Schreiber, Stuart L

“…The enthusiasm for phenotypic screening as an approach for small-molecule discovery has increased dramatically over the last several years. The recent increase…”
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Plasticity of ether lipids promotes ferroptosis susceptibility and evasion by Zou, Yilong, Henry, Whitney S., Ricq, Emily L., Graham, Emily T., Phadnis, Vaishnavi V., Maretich, Pema, Paradkar, Sateja, Boehnke, Natalie, Deik, Amy A., Reinhardt, Ferenc, Eaton, John K., Ferguson, Bryan, Wang, Wenyu, Fairman, Joshua, Keys, Heather R., Dančík, Vlado, Clish, Clary B., Clemons, Paul A., Hammond, Paula T., Boyer, Laurie A., Weinberg, Robert A., Schreiber, Stuart L.

“…Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various degenerative diseases and represents a targetable susceptibility in…”
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Effect of Early Initiation of Mechanical Circulatory Support on Survival in Cardiogenic Shock by Basir, Mir B., DO, Schreiber, Theodore L., MD, Grines, Cindy L., MD, Dixon, Simon F., MD, Moses, Jeffrey W., MD, Maini, Brijeshwar S., MD, Khandelwal, Akshay K., MD, Ohman, E. Magnus, MD, O'Neill, William W., MD

“…Abstract The role and timing of percutaneous mechanical circulatory support (MCS) devices in the treatment of acute myocardial infarction complicated by…”
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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis by Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.

“…Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by…”
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Printing Proteins as Microarrays for High-Throughput Function Determination by MacBeath, Gavin, Schreiber, Stuart L.

“…Systematic efforts are currently under way to construct defined sets of cloned genes for high-throughput expression and purification of recombinant proteins…”
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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles by Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

“…We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy…”
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Fluorescent Self‐Threaded Peptide Probes for Biological Imaging by Zhai, Canjia, Schreiber, Cynthia L., Padilla‐Coley, Sasha, Oliver, Allen G., Smith, Bradley D.

“…A general synthetic method creates a new class of covalently connected, self‐threaded, fluorescent molecular probes with figure‐eight topology, an encapsulated…”
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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells by Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L

“…Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is unknown. Using quantitative…”
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Single-Shot Correlations and Two-Qubit Gate of Solid-State Spins by Nowack, K. C., Shafiei, M., Laforest, M., Prawiroatmodjo, G. E. D. K., Schreiber, L. R., Reichl, C., Wegscheider, W., Vandersypen, L. M. K.

“…Measurement of coupled quantum systems plays a central role in quantum information processing. We have realized independent single-shot read-out of two…”
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