Search Results - "Schreiber, Jürg V."

On the Biodegradation of β-Peptides by Schreiber, Jürg. V., Frackenpohl, Jens, Moser, Frank, Fleischmann, Thomas, Kohler, Hans-Peter E., Seebach, Dieter

“…A consortium of microorganisms was established that was able to grow with the β‐tripeptide H‐β‐HVal‐β‐HAla‐β‐HLeu‐OH, with the β‐dipeptide H‐β‐HAla‐β‐HLeu‐OH,…”
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Total Synthesis of (+)-α-Onocerin in Four Steps via Four-Component Coupling and Tetracyclization Steps by Mi, Yuan, Schreiber, Jürg V, Corey, E. J

“…A remarkably short (four steps, 31% overall yield) enantioselective synthesis of the structurally unique C 2-symmetric tetracyclic triterpene (+)-α-onocerin…”
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Structure and Conformation of β-Oligopeptide Derivatives with Simple Proteinogenic Side Chains: Circular Dichroism and Molecular Dynamics Investigations by Seebach, Dieter, Schreiber, Jürg V., Abele, Stefan, Daura, Xavier, van Gunsteren, Wilfred F.

“…A careful CD analysis (Figs. 1 – 3 and 5; MeOH or H2O solutions) of β‐oligopeptides (1 – 6, B, C) containing four to seven β‐amino acids reveals that seemingly…”
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β-Peptide Conjugates: Syntheses and CD and NMR Investigations of β/α-Chimeric Peptides, of a DPA-β-Decapeptide, and of a PEGylated β-Heptapeptide by Gardiner, James, Mathad, Raveendra I., Jaun, Berhard, Schreiber, Jürg V., Flögel, Oliver, Seebach, Dieter

“…β3‐Peptides consisting of six, seven, and ten homologated proteinogenic amino acid residues have been attached to an α‐heptapeptide (all d‐amino acid residues;…”
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Solid-Phase Synthesis of a β-Dodecapeptide with Seven Functionalized Side Chains and CD-Spectroscopic Evidence for a Dramatic Structural Switch When Going from Water to Methanol Solution by Schreiber, Jürg V., Seebach, Dieter

“…An all‐β3‐dodecapeptide with a protected N‐terminal thiol‐anchoring group and with seven side chains has been synthesized in multi‐mg amounts by the manual…”
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Excursions of Synthetic Organic Chemists to the World of Oligomers and Polymers by Dieter Seebach, Albert K. Beck, Magnus Rueping, Jürg V. Schreiber, Holger Sellner

“…The activities of a group devoted to organic synthesis in the field of polymer and oligomer chemistry have led to new types of dendritic cross-linking…”
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The Outstanding Biological Stability of β- and γ-Peptides toward Proteolytic Enzymes: An In Vitro Investigation with Fifteen Peptidases by Frackenpohl, Jens, Arvidsson, Per I., Schreiber, Jürg V., Seebach, Dieter

“…A series of 36 linear and cyclic β‐ and γ‐peptides consisting of as few as two, and as many as 15 residues, was offered as substrates to 15 commercially…”
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Beta-peptides: twisting and turning by Gademann, K, Hintermann, T, Schreiber, J V

“…Oligomers of beta-amino acids (beta-peptides), which are readily available by standard meth ods either in solution or on solid support, adopt a large variety…”
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Synthesis of β3-Homophenylalanine-Derived Amino Acids and Peptides by Suzuki Coupling in Solution and on Solid Support by Limbach, Michael, Löweneck, Markus, Schreiber, Jürg V., Frackenpohl, Jens, Seebach, Dieter, Billich, Andreas

“…β‐Peptides and, to a certain extent, also mixed α,β‐peptides, are resistant to degradation by a variety of proteolytic enzymes that rapidly degrade natural…”
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Synthesis ofβ3-Homophenylalanine-Derived Amino Acids and Peptides bySuzuki Coupling in Solution and on Solid Support by Limbach, Michael, Löweneck, Markus, Schreiber, Jürg V., Frackenpohl, Jens, Seebach, Dieter, Billich, Andreas

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The Miraculous CD Spectra (and Secondary Structures?) of β-Peptides as They Grow Longer, Preliminary Communication by Seebach, Dieter, Schreiber, Jürg V., Arvidsson, Per I., Frackenpohl, Jens

“…The recently improved conditions for solid‐phase synthesis of β3‐peptides by the Fmoc strategy were used to synthesize a β‐tetracosapeptide (4, Scheme)…”
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On the Biodegradation of β-Peptides Part of the PhD thesis of J.V.S. Dissertation no. 14298, ETH Zürich, 2001 by Schreiber, Jürg. V., Frackenpohl, Jens, Moser, Frank, Fleischmann, Thomas, Kohler, Hans-Peter E., Seebach, Dieter

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Mixed β2/β3-Hexapeptides and β2/β3-Nonapeptides Folding to (P)-Helices with Alternating Twelve- and Ten-Membered Hydrogen-Bonded Rings by Rueping, Magnus, Schreiber, Jürg V., Lelais, Gérald, Jaun, Bernhard, Seebach, Dieter

“…The structural properties of four mixed β‐peptides with alternating β2/β3‐ or β3/β2‐sequences have been analyzed by two‐dimensional homonuclear 1H‐NMR‐ and CD…”
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Sequencing of ?-Peptides by Mass Spectrometry by Jürg V. Schreiber, Manfredo Quadroni, Dieter Seebach

“…Seven ?-peptides containing up to 18 ?2-, ?3- and ?2,3-amino acids have been subjected to ESI-tandem mass spectrometry (low-energy fragmentation, positive…”
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From the Biopolymer PHB to Biological Investigations of Unnatural ?- and ?-Peptides by Dieter Seebach, Matthias Albert, Per I. Arvidsson, Magnus Rueping, Jürg V. Schreiber

“…An overview is given of the past and present activities of our group in the field of chemical biology. Thus, the polymer of 3-hydroxybutanoic acid (PHS), which…”
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Excursions of Synthetic Organic Chemists to the World of Oligomers and Polymers by Dieter Seebach, Albert K. Beck, Magnus Rueping, Jürg V. Schreiber, Holger Sellner

“…The activities of a group devoted to organic synthesis in the field of polymer and oligomer chemistry have led to new types of dendritic cross-linking…”
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Biological and Pharmacokinetic Studies with ?-Peptides by Dieter Seebach, Ralph Woessner, Hauke Hennecke, Henk Schulz, Hansjörg Schild, Alexander K. Nussbaum, Bruno Martinoni, Jürg V. Schreiber, Stefan Abele, Francis Bitsch

“…Interactions and cleavage reactions of ?-amino acids and ?-oligopeptides (up to nine residues, carrying the side chains of Ala, Val, Leu, Ile, Phe, Ser, Lys,…”
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