Search Results - "Schramm, Stephen R"

Antigen-specific human antibodies from mice comprising four distinct genetic modifications by Lonberg, Nils, Taylor, Lisa D, Harding, Fiona A, Trounstine, Mary, Higgins, Kay M, Schramm, Stephen R, Kuo, Chiung-Chi, Mashayekh, Roshanak, Wymore, Kathryn, McCabe, James G, Munoz-O'Regan, Donna, O'Donnell, Susan L, Lapachet, Elizabeth S. G, Bengoechea, Tasha, Fishwild, Dianne M, Carmack, Condie E, Kay, Robert M, Huszar, Dennis

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High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice by Fishwild, Dianne M, O'Donnell, Susan L, Bengoechea, Tasha, Hudson, Debra V, Harding, Fiona, Bernhard, Susan L, Jones, Debbie, Kay, Robert M, Higgins, Kay M, Schramm, Stephen R, Lonberg, Nils

“…Human immunoglobulin transgenic mice provide a method of obtaining human monoclonal antibodies (Mabs) using conventional hybridoma technology. We describe a…”
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A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins by Taylor, Lisa D., Carmack, Condie E., Schramm, Stephen R., Mashayekh, Roshanak, Higgins, Kay M., Kuo, Chiung-Chi, Woodhouse, Clive, Kay, Robert M., Lonberg, Nils

“…We have generated transgenic mice that express a diverse repertoire of human sequence immunoglobulins. The expression of this repertoire is directed by light…”
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Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM by Taylor, L D, Carmack, C E, Huszar, D, Higgins, K M, Mashayekh, R, Sequar, G, Schramm, S R, Kuo, C C, O'Donnell, S L, Kay, R M

“…We have generated transgenic mice that contain human-sequence Ig miniloci and, because they are also homozygous for a targeted disruption of their endogenous…”
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Rational design of an animal model for alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent by Loring, Jeanne F., Paszty, Chris, Rose, Avidan, McIntosh, Tracy K., Murai, Hisayuki, Pierce, Jean E.S., Schramm, Stephen R., Wymore, Kathryn, Lee, Virginia M.-Y., Trojanowski, John Q., Peterson, Kenneth R.

“…A major obstacle to understanding the pathogenesis of Alzheimer's disease is the lack of easily studied animal models. Our approach is to apply transgenic…”
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