Search Results - "Schrama, David"

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression by Thiem, Alexander, Hesbacher, Sonja, Kneitz, Hermann, di Primio, Teresa, Heppt, Markus V, Hermanns, Heike M, Goebeler, Matthias, Meierjohann, Svenja, Houben, Roland, Schrama, David

“…Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral…”
Get full text

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma by Ritter, Cathrin, Fan, Kaiji, Paschen, Annette, Reker Hardrup, Sine, Ferrone, Soldano, Nghiem, Paul, Ugurel, Selma, Schrama, David, Becker, Jürgen C.

“…Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For…”
Get full text

Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens by Houben, Roland, Shuda, Masahiro, Weinkam, Rita, Schrama, David, Feng, Huichen, Chang, Yuan, Moore, Patrick S, Becker, Jürgen C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas by Kervarrec, Thibault, Tallet, Anne, Miquelestorena-Standley, Elodie, Houben, Roland, Schrama, David, Gambichler, Thilo, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Aubin, Francois, Bens, Guido, Tabareau-Delalande, Flore, Beneton, Nathalie, Fromont, Gaëlle, Arbion, Flavie, Leteurtre, Emmanuelle, Touzé, Antoine, Samimi, Mahtab, Guyétant, Serge

“…Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin mostly induced by Merkel cell polyomavirus integration. Cytokeratin 20 (CK20) positivity…”
Get full text

Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53 by Fan, Kaiji, Spassova, Ivelina, Gravemeyer, Jan, Ritter, Cathrin, Horny, Kai, Lange, Anja, Gambichler, Thilo, Ødum, Niels, Schrama, David, Schadendorf, Dirk, Ugurel, Selma, Becker, Jürgen C.

“…Merkel cell carcinoma (MCC) is a highly invasive and metastatic skin cancer. While high expression of miR-375 is a characteristic of MCC, it seems not to…”
Get full text

Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC by Becker, Jürgen C., Stang, Andreas, Hausen, Axel zur, Fischer, Nicole, DeCaprio, James A., Tothill, Richard W., Lyngaa, Rikke, Hansen, Ulla Kring, Ritter, Cathrin, Nghiem, Paul, Bichakjian, Christopher K., Ugurel, Selma, Schrama, David

“…Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of…”
Get full text

Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma by Fan, Kaiji, Ritter, Cathrin, Nghiem, Paul, Blom, Astrid, Verhaegen, Monique E, Dlugosz, Andrzej, Ødum, Niels, Woetmann, Anders, Tothill, Richard W, Hicks, Rodney J, Sand, Michael, Schrama, David, Schadendorf, Dirk, Ugurel, Selma, Becker, Jürgen C

“…Merkel cell carcinoma (MCC) is an aggressive skin cancer with neuroendocrine differentiation. There is an unmet need for MCC-specific blood-based surrogate…”
Get full text

Transcriptome-Wide Studies of Merkel Cell Carcinoma and Validation of Intratumoral CD8+ Lymphocyte Invasion As an Independent Predictor of Survival by PAULSON, Kelly G, IYER, Jayasri G, KOELLE, David M, GALLOWAY, DeniseA, LEONARD, J. Helen, MADELEINE, Margaret M, ARGENYI, Zsolt B, DISIS, Mary L, BECKER, Juergen C, CLEARY, Michele A, NGHIEM, Paul, TEGEDER, Andrew R, THIBODEAU, Renee, SCHELTER, Janell, KOBA, Shinichi, SCHRAMA, David, SIMONSON, William T, LEMOS, Bianca D, BYRD, David R

“…Merkel cell carcinoma (MCC) is a polyomavirus-associated skin cancer that is frequently lethal and lacks established prognostic biomarkers. This study sought…”
Get full text

Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma by Kervarrec, Thibault, Tallet, Anne, Miquelestorena-Standley, Elodie, Houben, Roland, Schrama, David, Gambichler, Thilo, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Aubin, Francois, Bens, Guido, Tabareau-Delalande, Flore, Beneton, Nathalie, Fromont, Gaëlle, Arbion, Flavie, Leteurtre, Emmanuelle, Herfs, Michael, Touzé, Antoine, Samimi, Mahtab, Guyétant, Serge

“…In 2008, Feng et al. identified Merkel cell polyomavirus integration as the primary oncogenic event in ~80% of Merkel cell carcinoma cases. The remaining…”
Get full text

Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells by Banicka, Veronika, Martens, Marie Christine, Panzer, Rüdiger, Schrama, David, Emmert, Steffen, Boeckmann, Lars, Thiem, Alexander

“…Defects in DNA repair pathways have been associated with an improved response to immune checkpoint inhibition (ICI). In particular, patients with the…”
Get full text

Anti-cancer therapies targeting the tumor stroma by Hofmeister, Valeska, Schrama, David, Becker, Jürgen C.

“…For anti-tumor therapy different strategies have been employed, e.g., radiotherapy, chemotherapy, or immunotherapy. Notably, these approaches do not only…”
Get full text

Loss of p14 diminishes immunogenicity in melanoma via non‐canonical Wnt signaling by reducing the peptide surface density by Wohlfarth, Jonas, Kosnopfel, Corinna, Faber, Dominic, Berthold, Marion, Siedel, Claudia, Bernhardt, Melissa, Schlosser, Andreas, Aprati, Tyler, Liu, David, Schrama, David, Houben, Roland, Schadendorf, Dirk, Goebeler, Matthias, Meierjohann, Svenja, Schilling, Bastian

“…Immunotherapy has achieved tremendous success in melanoma. However, only around 50% of advanced melanoma patients benefit from immunotherapy. Cyclin‐dependent…”
Get full text

Merkel Cell Polyomavirus Large T Antigen is Dispensable in G2 and M-Phase to Promote Proliferation of Merkel Cell Carcinoma Cells by Houben, Roland, Ebert, Marlies, Hesbacher, Sonja, Kervarrec, Thibault, Schrama, David

“…Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV), and proliferation of MCPyV-positive MCC…”
Get full text

Activation of the PI3K/AKT pathway in Merkel cell carcinoma by Hafner, Christian, Houben, Roland, Baeurle, Anne, Ritter, Cathrin, Schrama, David, Landthaler, Michael, Becker, Juergen C

“…Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with an increasing incidence. The understanding of the molecular carcinogenesis of MCC is…”
Get full text

Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion by Kosnopfel, Corinna, Wendlinger, Simone, Niessner, Heike, Siewert, Johannes, Sinnberg, Tobias, Hofmann, Angelika, Wohlfarth, Jonas, Schrama, David, Berthold, Marion, Siedel, Claudia, Sauer, Birgit, Jayanthan, Aarthi, Lenz, Georg, Dunn, Sandra E, Schilling, Bastian, Schittek, Birgit

“…The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an…”
Get full text

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells by Wobser, Marion, Weber, Alexandra, Glunz, Amelie, Tauch, Saskia, Seitz, Kristina, Butelmann, Tobias, Hesbacher, Sonja, Goebeler, Matthias, Bartz, René, Kohlhof, Hella, Schrama, David, Houben, Roland

“…Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach…”
Get full text

Presence of human polyomavirus 6 in mutation-specific BRAF inhibitor-induced epithelial proliferations by Schrama, David, Groesser, Leopold, Ugurel, Selma, Hafner, Christian, Pastrana, Diana V, Buck, Christopher B, Cerroni, Lorenzo, Theiler, Anna, Becker, Jürgen C

“…A frequent adverse effect of mutation-specific BRAF inhibitor therapy is the induction of epithelial proliferations including cutaneous squamous cell…”
Get more information

Antibody-Drug Conjugates as an Emerging Therapy in Oncodermatology by Esnault, Clara, Schrama, David, Houben, Roland, Guyétant, Serge, Desgranges, Audrey, Martin, Camille, Berthon, Patricia, Viaud-Massuard, Marie-Claude, Touzé, Antoine, Kervarrec, Thibault, Samimi, Mahtab

“…Antibody-drug conjugates (ADCs) are an emerging class of therapeutics, with twelve FDA- and EMA-approved drugs for hematological and solid cancers. Such drugs…”
Get full text

The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma by Adam, Christian, Baeurle, Anne, Brodsky, Jeffrey L, Wipf, Peter, Schrama, David, Becker, Jürgen Christian, Houben, Roland

“…Merkel Cell Carcinoma (MCC) is a rare and highly aggressive neuroendocrine skin cancer for which no effective treatment is available. MCC represents a human…”
Get full text

Investigation of the RB1-SOX2 axis constitutes a tool for viral status determination and diagnosis in Merkel cell carcinoma by Thanguturi, Soumanth, Tallet, Anne, Miquelestorena-Standley, Elodie, Coco, Catherine, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Blom, Astrid, Saiag, Philippe, Beneton, Nathalie, Bens, Guido, Zaragoza, Julia, Nardin, Charlee, Aubin, François, Dinulescu, Monica, Machet, Marie-Christine, Houben, Roland, Schrama, David, Collin, Christine, Fromont, Gaëlle, Jullie, Marie-Laure, Macagno, Nicolas, Gaboriaud, Pauline, Berthon, Patricia, Touzé, Antoine, Guyétant, Serge, Samimi, Mahtab, Kervarrec, Thibault

“…MCC (Merkel cell carcinoma) is an aggressive neuroendocrine cutaneous neoplasm. Integration of the Merkel cell polyomavirus (MCPyV) is observed in about 80% of…”
Get full text