Search Results - "Schrag, S."

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain by Bown, Corey W., Carare, Roxana O., Schrag, Matthew S., Jefferson, Angela L.

“…Perivascular spaces (PVS) are fluid-filled compartments that are part of the cerebral blood vessel wall and represent the conduit for fluid transport in and…”
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PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease by Nackenoff, Alex G, Hohman, Timothy J, Neuner, Sarah M, Akers, Carolyn S, Weitzel, Nicole C, Shostak, Alena, Ferguson, Shawn M, Mobley, Bret, Bennett, David A, Schneider, Julie A, Jefferson, Angela L, Kaczorowski, Catherine C, Schrag, Matthew S

“…Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this…”
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Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin by Kim, Hyosung, Leng, Kun, Park, Jinhee, Sorets, Alexander G., Kim, Suil, Shostak, Alena, Embalabala, Rebecca J., Mlouk, Kate, Katdare, Ketaki A., Rose, Indigo V. L., Sturgeon, Sarah M., Neal, Emma H., Ao, Yan, Wang, Shinong, Sofroniew, Michael V., Brunger, Jonathan M., McMahon, Douglas G., Schrag, Matthew S., Kampmann, Martin, Lippmann, Ethan S.

“…Astrocytes are critical components of the neurovascular unit that support blood-brain barrier (BBB) function. Pathological transformation of astrocytes to…”
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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states by Leng, Kun, Rose, Indigo V. L., Kim, Hyosung, Xia, Wenlong, Romero-Fernandez, Wilber, Rooney, Brendan, Koontz, Mark, Li, Emmy, Ao, Yan, Wang, Shinong, Krawczyk, Mitchell, TCW, Julia, Goate, Alison, Zhang, Ye, Ullian, Erik M., Sofroniew, Michael V., Fancy, Stephen P. J., Schrag, Matthew S., Lippmann, Ethan S., Kampmann, Martin

“…Astrocytes become reactive in response to insults to the central nervous system by adopting context-specific cellular signatures and outputs, but a systematic…”
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Detection, visualization and quantification of protein complexes in human Alzheimer’s disease brains using proximity ligation assay by Romero-Fernandez, Wilber, Carvajal-Tapia, Cristian, Prusky, Alex, Katdare, Ketaki A., Wang, Emmeline, Shostak, Alena, Ventura-Antunes, Lissa, Harmsen, Hannah J., Lippmann, Ethan S., Fuxe, Kjell, MacGurn, Jason A., Borroto-Escuela, Dasiel O., Schrag, Matthew S.

“…Examination of healthy and diseased human brain is essential to translational neuroscience. Protein–protein interactions play a pivotal role in physiological…”
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Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA by Metcalf, B.J., Chochua, S., Gertz, R.E., Hawkins, P.A., Ricaldi, J., Li, Z., Walker, H., Tran, T., Rivers, J., Mathis, S., Jackson, D., Glennen, A., Lynfield, R., McGee, L., Beall, B., Reingold, A., Brooks, S., Randel, H., Miller, L., White, B., Aragon, D., Barnes, M., Sadlowski, J., Petit, S., Cartter, M., Marquez, C., Wilson, M., Farley, M., Thomas, S., Tunali, A., Baughman, W., Harrison, L., Benton, J., Carter, T., Hollick, R., Holmes, K., Riner, A., Holtzman, C., Danila, R., MacInnes, K., Scherzinger, K., Angeles, K., Bareta, J., Butler, L., Khanlian, S., Mansmann, R., Nichols, M., Bennett, N., Zansky, S., Currenti, S., McGuire, S., Thomas, A., Schmidt, M., Thompson, J., Poissant, T., Schaffner, W., Barnes, B., Leib, K., Dyer, K., McKnight, L., Almendares, O., Hudson, J., McGlone, L., Whitney, C., Schrag, S., Langley, G.

“…Our objective was to evaluate and exploit a whole genome sequence (WGS) bioinformatics pipeline for predicting antimicrobial resistance and capsular serotypes…”
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Incidence and Severity of Invasive Streptococcus pneumoniae, Group A Streptococcus, and Group B Streptococcus Infections Among Pregnant and Postpartum Women by Deutscher, Meredith, Lewis, Melissa, Zell, Elizabeth R., Taylor, Thomas H., Van Beneden, Chris, Schrag, Stephanie

“…Background. The epidemiology of streptococcal infection in pregnant and postpartum women is poorly described in recent literature. We used data from multistate…”
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Vital Signs: Deficiencies in Environmental Control Identified in Outbreaks of Legionnaires’ Disease—North America, 2000–2014 by Garrison, L. E., Kunz, J. M., Cooley, L. A., Moore, M. R., Lucas, C., Schrag, S., Sarisky, J., Whitney, C. G.

“…Background The number of reported cases of Legionnaires’ disease, a severe pneumonia caused by the bacterium Legionella, is increasing in the United States…”
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Vital Signs: Health Care–Associated Legionnaires’ Disease Surveillance Data From 20 States and a Large Metropolitan Area—United States, 2015 by Soda, E. A., Barskey, A. E., Shah, P. P., Schrag, S., Whitney, C. G., Arduino, M. J., Reddy, S. C., Kunz, J. M., Hunter, C. M., Raphael, B. H., Cooley, L. A.

“…Background Legionnaires’ disease, a severe pneumonia, is typically acquired through inhalation of aerosolized water containing Legionella bacteria. Legionella…”
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Mild Cognitive Impairment Staging Yields Genetic Susceptibility, Biomarker, and Neuroimaging Differences by Moore, Elizabeth E, Liu, Dandan, Pechman, Kimberly R, Acosta, Lealani Mae Y, Bell, Susan P, Davis, L Taylor, Blennow, Kaj, Zetterberg, Henrik, Landman, Bennett A, Schrag, Matthew S, Hohman, Timothy J, Gifford, Katherine A, Jefferson, Angela L

“…While Alzheimer's disease (AD) is divided into severity stages, mild cognitive impairment (MCI) remains a solitary construct despite clinical and prognostic…”
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Group B Streptococcal Disease in the Era of Intrapartum Antibiotic Prophylaxis by Schrag, Stephanie J, Zywicki, Sara, Farley, Monica M, Reingold, Arthur L, Harrison, Lee H, Lefkowitz, Lewis B, Hadler, James L, Danila, Richard, Cieslak, Paul R, Schuchat, Anne

“…Invasive group B streptococcal disease emerged in the 1970s as a leading cause of neonatal morbidity and mortality in the United States. 1 – 4 In the 1990s, 4…”
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Adaptation to the fitness costs of antibiotic resistance in Escherichia coli by Schrag, Stephanie J., Perrot, Véronique, Levin, Bruce R.

“… Here we present evidence that these genetic adaptations to the costs of resistance can virtually preclude resistant lineages from reverting to sensitivity…”
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Effect of Short-Course, High-Dose Amoxicillin Therapy on Resistant Pneumococcal Carriage: A Randomized Trial by Schrag, Stephanie J, Peña, Chabela, Fernández, Josefina, Sánchez, Jacqueline, Gómez, Virgen, Pérez, Eddy, Feris, Jesús M, Besser, Richard E

“…CONTEXT Emerging drug resistance threatens the effectiveness of existing therapies for pneumococcal infections. Modifying the dose and duration of antibiotic…”
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Limiting the Spread of Resistant Pneumococci: Biological and Epidemiologic Evidence for the Effectiveness of Alternative Interventions by Schrag, S. J., Beall, B., Dowell, S. F.

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Perivascular spaces contribute to cognition beyond other small vessel disease markers by Passiak, Brittany S., Liu, Dandan, Kresge, Hailey A., Cambronero, Francis E., Pechman, Kimberly R., Osborn, Katie E., Gifford, Katherine A., Hohman, Timothy J., Schrag, Matthew S., Davis, L. Taylor, Jefferson, Angela L.

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Host-Parasite Coexistence: The Role of Spatial Refuges in Stabilizing Bacteria-Phage Interactions by Schrag, S. J., Mittler, J. E.

“…We manipulated a bacteria-phage model system to investigate empirical and theoretical conditions allowing for the coexistence of an Escherichia coli host with…”
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The Population Genetics of Antibiotic Resistance by Levin, B. R., Lipsitch, M., Perrot, V., Schrag, S., Antia, R., Simonsen, L., Moore Walker, N., Stewart, F. M.

“…Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the…”
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Emerging infectious disease: what are the relative roles of ecology and evolution? by Schrag, Stephanie J., Wiener, Pamela

“…The increasing threat of infectious diseases in humans has renewed interest in factors leading to the emergence of new diseases and the re-emergence of…”
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Reducing antibiotic resistance by Schrag, Stephanie J, Perrot, Véronique

“…Schrag and Perrot show that, although mutations to antibiotic resistance in bacteria may initially impose a considerable fitness burden, natural selection can…”
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Perivascular spaces contribute to cognition beyond other small vessel disease markers by Passiak, Brittany S, Liu, Dandan, Kresge, Hailey A, Cambronero, Francis E, Pechman, Kimberly R, Osborn, Katie E, Gifford, Katherine A, Hohman, Timothy J, Schrag, Matthew S, Davis, L Taylor, Jefferson, Angela L

“…OBJECTIVETo cross-sectionally relate multiple small vessel disease (SVD) neuroimaging markers to cognition among older adults. METHODSVanderbilt Memory & Aging…”
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