Search Results - "Schrader, E"

IgH chain class switch recombination: mechanism and regulation by Stavnezer, Janet, Schrader, Carol E

“…IgH class switching occurs rapidly after activation of mature naive B cells, resulting in a switch from expression of IgM and IgD to expression of IgG, IgE, or…”
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Resonance-stabilized hydrocarbon-radical chain reactions may explain soot inception and growth by Johansson, K O, Head-Gordon, M P, Schrader, P E, Wilson, K R, Michelsen, H A

“…Mystery surrounds the transition from gas-phase hydrocarbon precursors to terrestrial soot and interstellar dust, which are carbonaceous particles formed under…”
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Sunburn of Apple Fruit: Historical Background, Recent Advances and Future Perspectives by Racsko, J, Schrader, L. E

“…Sunburn is a physiological disorder of apples and other fruit species caused by excess solar radiation. Damage occurs in practically all growing regions of the…”
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Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes by Schiebel, Johannes, Gaspari, Roberto, Wulsdorf, Tobias, Ngo, Khang, Sohn, Christian, Schrader, Tobias E., Cavalli, Andrea, Ostermann, Andreas, Heine, Andreas, Klebe, Gerhard

“…Hydrogen bonds are key interactions determining protein-ligand binding affinity and therefore fundamental to any biological process. Unfortunately, explicit…”
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Mechanism and regulation of class switch recombination by Stavnezer, Janet, Guikema, Jeroen E J, Schrader, Carol E

“…Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a unique type of intrachromosomal…”
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Direct Observation of the Protonation States in the Mutant Green Fluorescent Protein by Shibazaki, Chie, Shimizu, Rumi, Kagotani, Yuji, Ostermann, Andreas, Schrader, Tobias E, Adachi, Motoyasu

“…Neutron crystallography has been used to elucidate the protonation states for the enhanced green fluorescent protein, which has revolutionized imaging…”
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Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression by Schrader, E

“…Treatment with St John's wort extract tablets (hypericum Ze 117) and the commonly used slow serotonin reuptake inhibitor (SSRI) fluoxetine was compared in…”
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Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer by Scales, Michael K, Velez-Delgado, Ashley, Steele, Nina G, Schrader, Hannah E, Stabnick, Anna M, Yan, Wei, Mercado Soto, Nayanna M, Nwosu, Zeribe C, Johnson, Craig, Zhang, Yaqing, Salas-Escabillas, Daniel J, Menjivar, Rosa E, Maurer, H Carlo, Crawford, Howard C, Bednar, Filip, Olive, Kenneth P, Pasca di Magliano, Marina, Allen, Benjamin L

“…Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is…”
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Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase by Casadei, Cecilia M., Gumiero, Andrea, Metcalfe, Clive L., Murphy, Emma J., Basran, Jaswir, Concilio, Maria Grazia, Teixeira, Susana C. M., Schrader, Tobias E., Fielding, Alistair J., Ostermann, Andreas, Blakeley, Matthew P., Raven, Emma L., Moody, Peter C. E.

“…Heme enzymes activate oxygen through formation of transient iron-oxo (ferryl) intermediates of the heme iron. A long-standing question has been the nature of…”
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Thymine Dimerization in DNA Is an Ultrafast Photoreaction by Schreier, Wolfgang J, Schrader, Tobias E, Koller, Florian O, Gilch, Peter, Crespo-Hernández, Carlos E, Swaminathan, Vijay N, Carell, Thomas, Zinth, Wolfgang, Kohler, Bern

“…Femtosecond time-resolved infrared spectroscopy was used to study the formation of cyclobutane dimers in the all-thymine oligodeoxynucleotide (dT)₁₈ by…”
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Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme by Kwon, Hanna, Basran, Jaswir, Casadei, Cecilia M., Fielding, Alistair J., Schrader, Tobias E., Ostermann, Andreas, Devos, Juliette M., Aller, Pierre, Blakeley, Matthew P., Moody, Peter C. E., Raven, Emma L.

“…Catalytic heme enzymes carry out a wide range of oxidations in biology. They have in common a mechanism that requires formation of highly oxidized ferryl…”
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Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4 by Yokoyama, Takeshi, Matsumoto, Kazunori, Ostermann, Andreas, Schrader, Tobias E., Nabeshima, Yuko, Mizuguchi, Mineyuki

“…Bromodomain‐containing protein 4 (BRD4) recognizes the acetylated lysine of histone H4 via its bromodomains, leading to the recruitment of positive…”
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Visualizing the protons in a metalloenzyme electron proton transfer pathway by Kwon, Hanna, Basran, Jaswir, Devos, Juliette M., Suardíaz, Reynier, van der Kamp, Marc W., Mulholland, Adrian J., Schrader, Tobias E., Ostermann, Andreas, Blakeley, Matthew P., Moody, Peter C. E., Raven, Emma L.

“…In redox metalloenzymes, the process of electron transfer often involves the concerted movement of a proton. These processes are referred to as proton-coupled…”
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Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography by Wan, Qun, Parks, Jerry M., Hanson, B. Leif, Fisher, Suzanne Zoe, Ostermann, Andreas, Schrader, Tobias E., Graham, David E., Coates, Leighton, Langan, Paul, Kovalevsky, Andrey

“…Glycoside hydrolase (GH) enzymes apply acid/base chemistry to catalyze the decomposition of complex carbohydrates. These ubiquitous enzymes accept protons from…”
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Scientific Basis of a Unique Formulation for Reducing Sunburn of Fruits by Schrader, Larry E

“…Sunburn, a major type of solar radiation injury, causes large economic losses of several fruits, vegetables, and ornamentals. Sunburn necrosis occurs in…”
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Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase by Yokoyama, Takeshi, Mizuguchi, Mineyuki, Ostermann, Andreas, Kusaka, Katsuhiro, Niimura, Nobuo, Schrader, Tabias E, Tanaka, Ichiro

“…Farnesyl pyrophosphate synthase (FPPS) catalyzes the condensation of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate to FPP and is known to be…”
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Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation by Stavnezer, Janet, Linehan, Erin K., Thompson, Mikayla R., Habboub, Ghaith, Ucher, Anna J., Kadungure, Tatenda, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Schrader, Carol E.

“…Somatic hypermutation (SHM) of antibody variable region genes is initiated in germinal center B cells during an immune response by activation-induced cytidine…”
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Nutritional and functional status in geriatric day hospital patients–MNA short form versus full MNA by Schrader, E., Grosch, E., Bertsch, T., Sieber, C. C., Volkert, Dorothee

“…Objectives The aims of this study were to determine the prevalence of malnutrition in patients of a geriatric day hospital using the Mini Nutritional…”
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Transpupillary collagen photocrosslinking for targeted modulation of ocular biomechanics by Gerberich, B.G., Hannon, B.G., Hejri, A., Winger, E.J., Schrader Echeverri, E., Nichols, L.M., Gersch, H.G., MacLeod, N.A., Gupta, S., Read, A.T., Ritch, M.D., Sridhar, S., Toothman, M.G., Gershon, G.S., Schwaner, S.A., Sánchez-Rodríguez, G., Goyal, V., Toporek, A.M., Feola, A.J., Grossniklaus, H.E., Pardue, M.T., Ethier, C.R., Prausnitz, M.R.

“…The central vision-threatening event in glaucoma is dysfunction and loss of retinal ganglion cells (RGCs), thought to be promoted by local tissue deformations…”
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Transition between protein-like and polymer-like dynamic behavior: Internal friction in unfolded apomyoglobin depends on denaturing conditions by Balacescu, Livia, Schrader, Tobias E., Radulescu, Aurel, Zolnierczuk, Piotr, Holderer, Olaf, Pasini, Stefano, Fitter, Jörg, Stadler, Andreas M.

“…Equilibrium dynamics of different folding intermediates and denatured states is strongly connected to the exploration of the conformational space on the…”
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