Search Results - "Schousboe, A"

Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents by Walls, A.B, Heimbürger, C.M, Bouman, S.D, Schousboe, A, Waagepetersen, H.S

“…Abstract The significance and functional roles of glycogen shunt activity in the brain are largely unknown. It represents the fraction of metabolized glucose…”
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Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase by Banke, T. G, Bowie, D, Lee, H.-K, Huganir, R. L, Schousboe, A, Traynelis, S. F

“…Modulation of postsynaptic AMPA receptors in the brain by phosphorylation may play a role in the expression of synaptic plasticity at central excitatory…”
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Neuron-glia interactions in glutamatergic neurotransmission: Roles of oxidative and glycolytic adenosine triphosphate as energy source by Schousboe, A., Sickmann, H.M., Bak, L.K., Schousboe, I., Jajo, F.S., Faek, S.A.A., Waagepetersen, H.S.

“…Glutamatergic neurotransmission accounts for a considerable part of energy consumption related to signaling in the brain. Chemical energy is provided by…”
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Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission by Schousboe, A., Sarup, A., Bak, L.K., Waagepetersen, H.S., Larsson, O.M.

“…The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes…”
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Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism by Jayakumar, A. R., Bak, L. K., Rama Rao, K. V., Waagepetersen, H. S., Schousboe, A., Norenberg, M. D.

“…Traumatic brain injury (TBI) is a devastating neurological disorder that usually presents in acute and chronic forms. Brain edema and associated increased…”
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Deletion of the betaine–GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice by Lehre, A.C, Rowley, N.M, Zhou, Y, Holmseth, S, Guo, C, Holen, T, Hua, R, Laake, P, Olofsson, A.M, Poblete-Naredo, I, Rusakov, D.A, Madsen, K.K, Clausen, R.P, Schousboe, A, White, H.S, Danbolt, N.C

“…Summary Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. Once released, it is removed from the extracellular…”
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Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor dl-threo-beta-benzyloxyaspartate (dl-TBOA) during physiological and ischemia-like conditions by Bonde, C., Sarup, A., Schousboe, A., Gegelashvili, G., Zimmer, J., Noraberg, J.

“…Maintenance of low extracellular glutamate ([Glu]O) preventing excitotoxic cell death requires fast removal of glutamate from the synaptic cleft. This…”
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573 HEPATIC ENCEPHALOPATHY IS ASSOCIATED WITH IMPAIRED BRAIN OXYGEN METABOLISM AND BLOOD FLOW, NOT INCREASED AMMONIA UPTAKE by Dam, G, Keiding, S, Münk, O.L, Ott, P, Vilstrup, H, Bak, L.K, Waagepetersen, H.S, Schousboe, A, Sørensen, M

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A Possible Role of the Non-GAT1 GABA Transporters in Transfer of GABA From GABAergic to Glutamatergic Neurons in Mouse Cerebellar Neuronal Cultures by Suñol, C., Babot, Z., Cristòfol, R., Sonnewald, U., Waagepetersen, H. S., Schousboe, A.

“…Cultures of dissociated cerebellum from 7-day-old mice were used to investigate the mechanism involved in synthesis and cellular redistribution of GABA in…”
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The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes by Johansen, Maja L., Bak, Lasse K., Schousboe, Arne, Iversen, Peter, Sørensen, Michael, Keiding, Susanne, Vilstrup, Hendrik, Gjedde, Albert, Ott, Peter, Waagepetersen, Helle S.

“…Cerebral hyperammonemia is a hallmark of hepatic encephalopathy, a debilitating condition arising secondary to liver disease. Pyruvate oxidation including…”
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Differential roles of alanine in GABAergic and glutamatergic neurons by Schousboe, A, Sonnewald, Ursula, Waagepetersen, Helle S

“…Studies in different preparations of neurons and astrocytes of alanine transport and activities of its metabolizing enzyme alanine aminotransferase have led to…”
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GDNF pre-treatment aggravates neuronal cell loss in oxygen–glucose deprived hippocampal slice cultures: a possible effect of glutamate transporter up-regulation by Bonde, C., Sarup, A., Schousboe, A., Gegelashvili, G., Noraberg, J., Zimmer, J.

“…Besides its neurotrophic and neuroprotective effects on dopaminergic neurons and spinal motoneurons, glial cell line-derived neurotrophic factor (GDNF) has…”
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Workshop W04: Glycogen: a static or dynamic energy source? by McKenna, M., Schousboe, A.

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Role of taurine in osmoregulation in brain cells: Mechanisms and functional implications by Pasantes-Morales, H., Schousboe, A.

“…All cells including neurons and glial cells are able to keep their volume within a very limited range. The volume regulatory mechanism involves changes in the…”
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Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA by Belhage, B, Hansen, G H, Schousboe, A

“…Neurotransmitter release and changes in the concentration of intracellular free calcium ([Ca++]i) were studied in cultured GABAergic cerebral cortical neurons,…”
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Mobilization of Dantrolene-Sensitive Intracellular Calcium Pools is Involved in the Cytotoxicity Induced by Quisqualate and N-Methyl-D- Aspartate but not by 2-Amino-3-(3-Hydroxy-5-Methylisoxazol-4-yl)Propionate and Kainate in Cultured Cerebral Cortical Neurons by Frandsen, Aase, Schousboe, Arne

“…By using primary cultures of cerebral cortical neurons, it has been demonstrated that the antihyperthermia drug dantrolene protects against cytotoxicity…”
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Analysis of glutamine accumulation in rat brain mitochondria in the presence of a glutamine uptake inhibitor, histidine, reveals glutamine pools with a distinct access to deamidation by Ziemińska, E, Hilgier, W, Waagepetersen, H S, Hertz, L, Sonnewald, U, Schousboe, A, Albrecht, J

“…Rat cerebral nonsynaptic mitochondria were incubated in medium containing 2 mM glutamine (Gln) or 2 mM glutamate (Glu), in the presence of a Gln uptake…”
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Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling by Sonnewald, U, Westergaard, N, Jones, P, Taylor, A, Bachelard, H S, Schousboe, A

“…Metabolism of [U-13C5]glutamine was studied in primary cultures of cerebral cortical astrocytes in the presence or absence of extracellular glutamate…”
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Metabolic trafficking between neurons and astrocytes: the glutamate/glutamine cycle revisited by Westergaard, N, Sonnewald, U, Schousboe, A

“…Use of 13C-labeled precursors for the neuroactive amino acids glutamate and GABA as well as [U-13C]glutamate and glutamine combined with NMR spectroscopy has…”
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On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1 by Lund, T.M., Christensen, E., Kristensen, A.S., Schousboe, A., Lund, A.M.

“…Glutaric acidemia type 1 (GA1) is an autosomal recessively inherited deficiency of glutaryl‐CoA dehydrogenase. Accumulating metabolites, 3‐hydroxyglutaric…”
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