Search Results - "Schormann, N."

Uracil‐DNA glycosylases—Structural and functional perspectives on an essential family of DNA repair enzymes by Schormann, N., Ricciardi, R., Chattopadhyay, D.

“…Uracil‐DNA glycosylases (UDGs) are evolutionarily conserved DNA repair enzymes that initiate the base excision repair pathway and remove uracil from DNA. The…”
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Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function by Schormann, N., Senkovich, O., Walker, K., Wright, D.L., Anderson, A.C., Rosowsky, A., Ananthan, S., Shinkre, B., Velu, S., Chattopadhyay, D.

“…We have employed a structure‐based three‐dimensional quantitative structure–activity relationship (3D‐QSAR) approach to predict the biochemical activity for…”
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Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase by Schormann, N., Banerjee, S., Ricciardi, R., Chattopadhyay, D.

“…Poxvirus uracil DNA glycosylases are the most diverse members of the family I uracil DNA glycosylases (UNGs). The crystal structure of the uracil complex of…”
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Structural genomics of caenorhabditis elegans: Crystal structure of calmodulin by Symersky, J., Lin, G., Li, S., Qiu, S., Carson, M., Schormann, N., Luo, M.

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Expression, purification, crystallization and preliminary crystallographic analysis of recombinant pteridine reductase of Trypanosoma cruzi by Schormann, Norbert, Pal, Biswajit, Chattopadhyay, Debasish

“…The recombinant version of Trypanosoma cruzi pteridine reductase was expressed in Escherichia coli, purified to homogeneity from the soluble fraction of…”
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Structural genomics of Caenorhabditis elegans: structure of the BAG domain by Symersky, J., Zhang, Y., Schormann, N., Li, S., Bunzel, R., Pruett, P., Luan, C.-H., Luo, M.

“…Binding of the BAG domain to the eukaryotic chaperone heat‐shock protein (Hsp70) promotes ATP‐dependent release of the protein substrate from Hsp70. Although…”
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Tertiary Structure of an Amyloid Immunoglobulin Light Chain Protein: A Proposed Model for Amyloid Fibril Formation by Schormann, Norbert, Murrell, Jill R., Liepnieks, Juris J., Benson, Merrill D.

“…An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete amino acid sequence of the…”
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Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor by Schormann, Norbert, Pal, Biswajit, Senkovich, Olga, Carson, Mike, Howard, Andrew, Smith, Craig, DeLucas, Lawrence, Chattopadhyay, Debasish

“…Reduced pteridines are required for a number of important cellular functions. Trypanosomatid parasites, unlike their mammalian hosts, are pteridine auxotrophs…”
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Trypanosoma cruzi genome encodes a pteridine reductase 2 protein by Senkovich, Olga, Pal, Biswajit, Schormann, Norbert, Chattopadhyay, Debasish

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Structure of sperm-specific protein SSP-19 from Caenorhabditis elegans by Schormann, Norbert, Symersky, Jindrich, Luo, Ming

“…Structural data are reported for SSP‐19, a sperm‐specific protein (SSP) family member from Caenorhabditis elegans. The SSP family [also known as the major…”
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Protein aging hypothesis of Alzheimer disease by Orpiszewski, Jozef, Schormann, Norbert, Kluve-Beckerman, Barbara, Liepnieks, Juris J., Benson, Merrill D.

“…ABSTRACT Alzheimer disease (AD), the most common form of aging‐related neurodegenerative disorders, is associated with formation of fibrillar deposits of…”
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Structural Basis for the Expanded Substrate Specificity of Vaccinia Virus Thymidine Kinase: Insight from the Crystal Structure by Prichard, Mark, Keith, Kathy, Johnson, Mary, Schormann, Norbert, Samal, Alexandra, Chattopadhyay, Debasish, Kern, Earl

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Tertiary structures of three amyloidogenic transthyretin variants and implications for amyloid fibril formation by Benson, M.D., Schormann, N.

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Tertiary structures of amyloidogenic and non-amyloidogenic transthyretin variants: new model for amyloid fibril formation by Schormann, Norbert, Murrell, Jill R., Benson, Merrill D.

“…The most common form of hereditary systemic amyloidosis is familial amyloidotic poly neuropathy associated with single amino acid changes in the plasma protein…”
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Structure, function and metabolism of transthyretin by Benson, M.D., Murrell, J.R., Schormann, N., Liepnieks, J.J., Uemichi, T.

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Expression, purification, and characterization of recombinant Drosophila choline acetyltransferase by Wu, D, Schormann, N, Lian, W, Deisenhofer, J, Hersh, L B

“…A cDNA for Drosophila choline acetyltransferase (EC 2.3.1.6; ChAT) was fused with a polyhistidine sequence and expressed in Escherichia coli. The recombinant…”
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Docking and biological activity of pteridine analogs: search for inhibitors of pteridine reductase enzymes from Trypanosoma cruzi by Schormann, Norbert, Senkovich, Olga, Ananthan, Subramaniam, Chattopadhyay, Debasish

“…The program DOCK4.0 was used to predict and evaluate the binding mode for a set of inhibitors from a compound library of pteridine analogs against Trypanosoma…”
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