Search Results - "Schopfer, Francisco"

Formation and Signaling Actions of Electrophilic Lipids by Schopfer, Francisco J, Cipollina, Chiara, Freeman, Bruce A

“…Schopfer et al examine signaling and formation actions of lipids that are electrophilic. Sensing mechanisms are included in the examination…”
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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling by Hansen, Anne Louise, Buchan, Gregory J., Rühl, Michael, Mukai, Kojiro, Salvatore, Sonia R., Ogawa, Emari, Andersen, Sidsel D., Iversen, Marie B., Thielke, Anne L., Gunderstofte, Camilla, Motwani, Mona, Møller, Charlotte T., Jakobsen, Andreas S., Fitzgerald, Katherine A., Roos, Jessica, Lin, Rongtuan, Maier, Thorsten J., Goldbach-Mansky, Raphaela, Miner, Cathrine A., Qian, Wei, Miner, Jonathan J., Rigby, Rachel E., Rehwinkel, Jan, Jakobsen, Martin R., Arai, Hiroyuki, Taguchi, Tomohiko, Schopfer, Francisco J., Olagnier, David, Holm, Christian K.

“…The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host…”
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Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology by Schopfer, Francisco J., Khoo, Nicholas K.H.

“…In addition to supporting cellular energetic demands and providing building blocks for lipid synthesis, fatty acids (FAs) are precursors of potent signaling…”
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Mass spectrometry-based study defines the human urine nitrolipidome by Salvatore, Sonia R., Rowart, Pascal, Schopfer, Francisco J.

“…Nitrated fatty acids (NO2-FA) are an endogenous class of signaling mediators formed mainly during digestion and inflammation. The signaling actions of NO2-FA…”
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Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases by Schopfer, Francisco J., Vitturi, Dario A., Jorkasky, Diane K., Freeman, Bruce A.

“…Nitrated oleic acid (NO2-OA) was first identified in 2003, and after the characterization of its formation and thiol reactivity, it was used as a prototypical…”
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Olives and olive oil are sources of electrophilic fatty acid nitroalkenes by Fazzari, Marco, Trostchansky, Andrés, Schopfer, Francisco J, Salvatore, Sonia R, Sánchez-Calvo, Beatriz, Vitturi, Dario, Valderrama, Raquel, Barroso, Juan B, Radi, Rafael, Freeman, Bruce A, Rubbo, Homero

“…Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide…”
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Nitro-fatty acids: promising agents for the development of new cancer therapeutics by Roos, Jessica, Manolikakes, Georg, Schlomann, Uwe, Klinke, Anna, Schopfer, Francisco J., Neumann, Carola A., Maier, Thorsten J.

“…Anti-inflammatory nitro-fatty acids (NO2-FAs) are endogenous and pleiotropic mediators that exert tumor-suppressive effects via a novel mechanism of action by…”
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STING palmitoylation as a therapeutic target by Hansen, Anne Louise, Mukai, Kojiro, Schopfer, Francisco J., Taguchi, Tomohiko, Holm, Christian K.

“…Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING- associated vasculopathy with…”
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Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives by Cipollina, Chiara, Salvatore, Sonia R, Muldoon, Matthew F, Freeman, Bruce A, Schopfer, Francisco J

“…Dietary ω-3 polyunsaturated fatty acids (PUFAs) decrease cardiovascular risk via suppression of inflammation. The generation of electrophilic α,β-unsaturated…”
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Digestive interaction between dietary nitrite and dairy products generates novel nitrated linolenic acid products by Salvatore, Sonia R., Gómez-Cortés, Pilar, Rowart, Pascal, Woodcock, Steven R., Angel de la Fuente, Miguel, Chang, Fei, Schopfer, Francisco J.

“…[Display omitted] •Gastric interaction of milk RA and RLA with nitrite leads to NO2-RA and NO2-RLA.•RA and RLA are the only substrates for nitration present in…”
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Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism by Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa

“…Nitro-fatty acids (NO2-FAs) are electrophilic signaling mediators formed in vivo via nitric oxide (NO)- and nitrite (NO2−)-dependent reactions. Nitro-fatty…”
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Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling by Rahaman, Mizanur M, Nguyen, Anh T, Miller, Megan P, Hahn, Scott A, Sparacino-Watkins, Courtney, Jobbagy, Soma, Carew, Nolan T, Cantu-Medellin, Nadiezhda, Wood, Katherine C, Baty, Catherine J, Schopfer, Francisco J, Kelley, Eric E, Gladwin, Mark T, Martin, Emil, Straub, Adam C

“…RATIONALE:Soluble guanylate cyclase (sGC) heme iron, in its oxidized state (Fe), is desensitized to NO and limits cGMP production needed for downstream…”
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Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids[S] by Fazzari, Marco, Vitturi, Dario A., Woodcock, Steven R., Salvatore, Sonia R., Freeman, Bruce A., Schopfer, Francisco J.

“…Electrophilic nitro-fatty acids [NO2-FAs (fatty acid nitroalkenes)] showed beneficial signaling actions in preclinical studies and safety in phase 1 clinical…”
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Nitrated fatty acids: synthesis and measurement by Woodcock, Steven R., Bonacci, Gustavo, Gelhaus, Stacy L., Schopfer, Francisco J.

“…Nitrated fatty acids are the product of nitrogen dioxide reaction with unsaturated fatty acids. The discovery of peroxynitrite and peroxidase-induced nitration…”
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Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships by Khoo, Nicholas K. H., Li, Lihua, Salvatore, Sonia R., Schopfer, Francisco J., Freeman, Bruce A.

“…Fatty acid nitroalkene derivatives (NO 2 -FA) activate Nrf2-regulated antioxidant gene expression and inhibit NF-κB-dependent cytokine expression. To better…”
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The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling by Freeman, Bruce A., O'Donnell, Valerie B., Schopfer, Francisco J.

“…Foundational advances in eicosanoid signaling, the free radical biology of oxygen and nitric oxide and mass spectrometry all converged to enable the discovery…”
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Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids by Freeman, Bruce A, Schopfer, Francisco J, Groeger, Alison L, Cipollina, Chiara, Cole, Marsha P, Woodcock, Steven R, Bonacci, Gustavo, Rudolph, Tanja K, Rudolph, Volker

“…Six new species of electrophilic lipids identified in activated macrophages are derived from COX-2 action on ω-3 fatty acids and mediate anti-inflammatory and…”
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Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice by Chartoumpekis, Dionysios V, Palliyaguru, Dushani L, Wakabayashi, Nobunao, Fazzari, Marco, Khoo, Nicholas K H, Schopfer, Francisco J, Sipula, Ian, Yagishita, Yoko, Michalopoulos, George K, O'Doherty, Robert M, Kensler, Thomas W

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a canonical regulator of cytoprotective gene expression, but evidence of its cross talk with other…”
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Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death by Carew, Nolan T, Schmidt, Heidi M, Yuan, Shuai, Galley, Joseph C, Hall, Robert, Altmann, Helene M, Hahn, Scott A, Miller, Megan P, Wood, Katherine C, Gabris, Bethann, Stapleton, Margaret C, Hartwick, Sean, Fazzari, Marco, Wu, Yijen L, Trebak, Mohamed, Kaufman, Brett A, McTiernan, Charles F, Schopfer, Francisco J, Navas, Placido, Thibodeau, Patrick H, McNamara, Dennis M, Salama, Guy, Straub, Adam C

“…Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes;…”
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Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms by Villacorta, Luis, Gao, Zhen, Schopfer, Francisco J, Freeman, Bruce A, Chen, Y Eugene

“…Electrophilic nitro-fatty acids (NO2-FAs) are endogenously formed by redox reactions of nitric oxide ((.)NO)- and nitrite ((.)NO2)- derived nitrogen dioxide…”
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