Search Results - "Schon, Eric"

Mitochondria: The Next (Neurode)Generation by Schon, Eric A., Przedborski, Serge

“…Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the nervous system whose underlying mechanisms of cell death remain unknown…”
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Human mitochondrial DNA: roles of inherited and somatic mutations by Schon, Eric A., DiMauro, Salvatore, Hirano, Michio

“…Key Points Mitochondrial diseases are among the most common genetic disorders. They can result from mutations in the mitochondrial genome or nuclear genome…”
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Mitochondria-associated ER membranes in Alzheimer disease by Schon, Eric A., Area-Gomez, Estela

“…Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of…”
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Mitochondria-associated ER membranes and Alzheimer disease by Area-Gomez, Estela, Schon, Eric A

“…The series of events underlying the pathogenesis of Alzheimer disease (AD) in unknown. The most widely accepted hypothesis is called the amyloid cascade, based…”
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On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis by Area-Gomez, Estela, Schon, Eric A.

“…ABSTRACT The pathogenesis of Alzheimer's disease (AD) is currently unclear and is the subject of much debate. The most widely accepted hypothesis designed to…”
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Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas by Area-Gomez, Estela, Guardia-Laguarta, Cristina, Schon, Eric A, Przedborski, Serge

“…Mitochondrial respiratory deficiencies have been observed in numerous neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. For decades,…”
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NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease by Cerutti, Raffaele, Pirinen, Eija, Lamperti, Costanza, Marchet, Silvia, Sauve, Anthony A., Li, Wei, Leoni, Valerio, Schon, Eric A., Dantzer, Françoise, Auwerx, Johan, Viscomi, Carlo, Zeviani, Massimo

“…Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of…”
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Mitochondrial Disorders in the Nervous System by DIMAURO, Salvatore, SCHON, Eric A

“…Mitochondrial diseases (encephalomyopathies) have traditionally been ascribed to defects of the respiratory chain, which has helped researchers explain their…”
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The clinical maze of mitochondrial neurology by DiMauro, Salvatore, Schon, Eric A., Carelli, Valerio, Hirano, Michio

“…Mitochondrial diseases are a complex and clinically heterogeneous group of disorders, which— together with our poor understanding of the underlying…”
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Towards a Unitary Hypothesis of Alzheimer's Disease Pathogenesis by Area-Gomez, Estela, Schon, Eric A

“…The "amyloid cascade" hypothesis of Alzheimer's disease (AD) pathogenesis invokes the accumulation in the brain of plaques (containing the amyloid-β protein…”
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In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis by Viscomi, Carlo, Bottani, Emanuela, Civiletto, Gabriele, Cerutti, Raffaele, Moggio, Maurizio, Fagiolari, Gigliola, Schon, Eric A., Lamperti, Costanza, Zeviani, Massimo

“…Increased mitochondrial biogenesis by activation of PPAR- or AMPK/PGC-1α-dependent homeostatic pathways has been proposed as a treatment for mitochondrial…”
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Mitochondrial Respiratory-Chain Diseases by DiMauro, Salvatore, Schon, Eric A

“…The mitochondrial respiratory chain has the crucial function of supplying the cell with energy in the form of ATP. Mutations affecting this chain can arise in…”
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A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease by Area-Gomez, Estela, de Groof, Ad, Bonilla, Eduardo, Montesinos, Jorge, Tanji, Kurenai, Boldogh, Istvan, Pon, Liza, Schon, Eric A.

“…In the last few years, increased emphasis has been devoted to understanding the contribution of mitochondria-associated endoplasmic reticulum (ER) membranes…”
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Bioenergetics through thick and thin by Schon, Eric A

“…Membrane fluidity influences the efficiency of oxidative energy metabolism The cells in all biological systems are composed of a limited number of molecular…”
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α-Synuclein is localized to mitochondria-associated ER membranes by Guardia-Laguarta, Cristina, Area-Gomez, Estela, Rüb, Cornelia, Liu, Yuhui, Magrané, Jordi, Becker, Dorothea, Voos, Wolfgang, Schon, Eric A, Przedborski, Serge

“…Familial Parkinson disease is associated with mutations in α-synuclein (α-syn), a presynaptic protein that has been localized not only to the cytosol, but also…”
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Upregulated function of mitochondria-associated ER membranes in Alzheimer disease by Area-Gomez, Estela, del Carmen Lara Castillo, Maria, Tambini, Marc D, Guardia-Laguarta, Cristina, de Groof, Ad J C, Madra, Moneek, Ikenouchi, Junichi, Umeda, Masato, Bird, Thomas D, Sturley, Stephen L, Schon, Eric A

“…Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ‐secretase, via an unknown mechanism. We recently…”
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Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease by Pera, Marta, Larrea, Delfina, Guardia‐Laguarta, Cristina, Montesinos, Jorge, Velasco, Kevin R, Agrawal, Rishi R, Xu, Yimeng, Chan, Robin B, Di Paolo, Gilbert, Mehler, Mark F, Perumal, Geoffrey S, Macaluso, Frank P, Freyberg, Zachary Z, Acin‐Perez, Rebeca, Enriquez, Jose Antonio, Schon, Eric A, Area‐Gomez, Estela

“…In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa…”
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Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome by Siegmund, Stephanie E, Yang, Hua, Sharma, Rohit, Javors, Martin, Skinner, Owen, Mootha, Vamsi, Hirano, Michio, Schon, Eric A

“…Mitochondrial disorders affecting oxidative phosphorylation (OxPhos) are caused by mutations in both the nuclear and mitochondrial genomes. One promising…”
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ApoE4 upregulates the activity of mitochondria-associated ER membranes by Tambini, Marc D, Pera, Marta, Kanter, Ellen, Yang, Hua, Guardia-Laguarta, Cristina, Holtzman, David, Sulzer, David, Area-Gomez, Estela, Schon, Eric A

“…In addition to the appearance of senile plaques and neurofibrillary tangles, Alzheimer's disease (AD) is characterized by aberrant lipid metabolism and early…”
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A new role for [alpha]-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication by Guardia-Laguarta, Cristina, Area-Gomez, Estela, Schon, Eric A, Przedborski, Serge

“…Familial cases of Parkinson's disease (PD) can be associated with overexpression or mutation of [alpha]-synuclein, a synaptic protein reported to be localized…”
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