Search Results - "Schomberg, Dominic T."

Miniature Swine for Preclinical Modeling of Complexities of Human Disease for Translational Scientific Discovery and Accelerated Development of Therapies and Medical Devices by Schomberg, Dominic T., Tellez, Armando, Meudt, Jennifer J., Brady, Dane A., Dillon, Krista N., Arowolo, Folagbayi K., Wicks, Joan, Rousselle, Serge D., Shanmuganayagam, Dhanansayan

“…Noncommunicable diseases, including cardiovascular disease, diabetes, chronic respiratory disease, and cancer, are the leading cause of death in the world. The…”
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Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model by McLean, Dalton T, Meudt, Jennifer J, Lopez Rivera, Loren D, Schomberg, Dominic T, Pavelec, Derek M, Duellman, Tyler T, Buehler, Darya G, Schwartz, Patrick B, Graham, Melissa, Lee, Laura M, Graff, Keri D, Reichert, Jamie L, Bon-Durant, Sandra S, Konsitzke, Charles M, Ronnekleiv-Kelly, Sean M, Shanmuganayagam, Dhanansayan, Rubinstein, C Dustin

“…Neurofibromatosis Type 1 (NF1) is one of the most common genetically inherited disorders that affects 1 in 3000 children annually. Clinical manifestations vary…”
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Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 and TP53 Mutant Porcine Models Reveals Overlooked Challenges in Precision Modeling of Human Diseases by Rubinstein, Clifford Dustin, McLean, Dalton T, Lehman, Brent P, Meudt, Jennifer J, Schomberg, Dominic T, Krentz, Kathy J, Reichert, Jamie L, Meyer, Mark B, Adams, Marie, Konsitzke, Charles M, Shanmuganayagam, Dhanansayan

“…Genome editing in pigs has been made efficient, practical, and economically viable by the CRISPR/Cas9 platform, representing a promising new era in…”
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Comparative Morphometry of the Wisconsin Miniature SwineTM Thoracic Spine for Modeling Human Spine in Translational Spinal Cord Injury Research by Miranpuri, Gurwattan Singh, Schomberg, Dominic T., Stan, Patricia, Chopra, Abhishek, Buttar, Seah, Wood, Aleksandar, Radzin, Alexandra, Meudt, Jennifer J., Resnick, Daniel K., Shanmuganayagam, Dhanansayan

“…Background/Aims: Spine and spinal cord pathologies and associated neuropathic pain are among the most complex medical disorders to treat. While rodent models…”
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Translational Relevance of Swine Models of Spinal Cord Injury by Schomberg, Dominic T, Miranpuri, Gurwattan S, Chopra, Abhishek, Patel, Kush, Meudt, Jennifer J, Tellez, Armando, Resnick, Daniel K, Shanmuganayagam, Dhanansayan

“…Spinal cord injury (SCI) is a physically and psychologically devastating clinical condition. The typical treatment regimens of decompressive surgery and…”
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Brachial plexus anatomy in the miniature swine as compared to human by Hanna, Amgad S., Hellenbrand, Daniel J., Schomberg, Dominic T., Salamat, Shahriar M., Loh, Megan, Wheeler, Lea, Hanna, Barbara, Ozaydin, Burak, Meudt, Jennifer, Shanmuganayagam, Dhanansayan

“…Brachial plexus injury (BPI) occurs when the brachial plexus is compressed, stretched, or avulsed. Although rodents are commonly used to study BPI, these…”
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Role of Matrix Metalloproteinases 2 in Spinal Cord Injury-Induced Neuropathic Pain by Miranpuri, Gurwattan S., Schomberg, Dominic T., Alrfaei, Bahauddeen, King, Kevin C., Rynearson, Bryan, Wesley, Vishwas S., Khan, Nayab, Obiakor, Kristen, Wesley, Umadevi V., Resnick, Daniel K.

“…Neuropathic pain (NP) affects approximately 4 million people in the United States with spinal cord injury (SCI) being a common cause. Matrix metalloproteinases…”
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Tissue Specific Expression of Neurofibromin Isoforms in Swine by Schomberg, Dominic T., Rubinstein, Clifford Dustin, Meudt, Jennifer J., Shanmuganayagam, Dhanansayan

“…Neurofibromatosis type 1 (NF1) is one of the most common monogenic disorders and affects 1 in 2,500 children. The disorder manifests in varying, complex…”
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Age‐ and Tissue‐Specific Alternative Splicing of the Neurofibromin Gene in Swine by Schomberg, Dominic T., Brown, Greta R., Rubinstein, Clifford Dustin, Meudt, Jennifer J., Reichert, Jamie L., Shanmuganayagam, Dhanansayan

“…Abstract only Neurofibromatosis type 1 (NF1) is one of the most common monogenic disorders that affects 1 in 2,500 children. The disorder manifests in varying,…”
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Optimized Induction of Neurospheres from Porcine Mesenchymal Stem Cells by Schomberg, Dominic T., Wood, Aleksandar, Singh, Harpreet, Meudt, Jennifer J., Shanmuganayagam, Dhanansayan

“…Neurospheres are free‐floating clusters of cells that provide researchers a unique method to investigate neural stem cells. Stem cells typically grow as an…”
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Methodology for Efficient and Biosecure Genetic Engineering of Biomedical Swine Models by Meudt, Jennifer J., Reichert, Jamie L., Lopez, Ana Cecilia Escobar, Krentz, Kathleen J., Rubinstein, Clifford Dustin, Lehman, Brent P., Schomberg, Dominic T., Monson, Ricky L., Willenburg, Kilby, Frank, Jennifer M., Graff, Keri D., Shanmuganayagam, Dhanansayan

“…Abstract only The genetic proximity of swine to human, the overwhelming anatomical, physiological and pathophysiological similarities, and the ability to mimic…”
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Optimization of CRISPR/Cas9 Platform‐Mediated Gene Editing of Swine Embryos for The Creation of Novel Biomedical Swine Models by Schomberg, Dominic T., Meudt, Jennifer J., Krentz, Kathleen J., Rubinstein, C. Dustin, Zhang, Aiying, Shanmuganayagam, Dhanansayan

“…Abstract only Swine are increasingly used to model complex human diseases for basic scientific discovery and for the preclinical development and validation of…”
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Exogenous Oxidation of Lipids Reduces The Deleterious Effects of A High Fat Diet Composed of These Lipids in A Swine Model of Familial Hypercholesterolemia and Spontaneous Atherosclerosis by Arowolo, Folagbayi, Meudt, Jennifer J., Cabelka, Colin, Schomberg, Dominic T., Chesmore, Nathan J., López, Ana Cecilia Escobar, Trace, Sam T., Reichert, Jamie L., Crenshaw, Thomas D., Richards, Mark P., Shanmuganayagam, Dhanansayan

“…Abstract only High‐fat diets elevate the risk of atherosclerotic cardiovascular disease (CVD), especially in individuals susceptible to dyslipidemia. Dietary…”
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Comparative Morphometry of the Wisconsin Miniature Swine TM Thoracic Spine for Modeling Human Spine in Translational Spinal Cord Injury Research by Miranpuri, Gurwattan Singh, Schomberg, Dominic T, Stan, Patricia, Chopra, Abhishek, Buttar, Seah, Wood, Aleksandar, Radzin, Alexandra, Meudt, Jennifer J, Resnick, Daniel K, Shanmuganayagam, Dhanansayan

“…Spine and spinal cord pathologies and associated neuropathic pain are among the most complex medical disorders to treat. While rodent models are widely used in…”
Get full text