Search Results - "Schomber, Tibor"

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo by Tiedt, Ralph, Schomber, Tibor, Hao-Shen, Hui, Skoda, Radek C.

“…To generate transgenic mice that express Cre-recombinase exclusively in the megakaryocytic lineage, we modified a mouse bacterial artificial chromosome (BAC)…”
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Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease by Bénardeau, Agnès, Kahnert, Antje, Schomber, Tibor, Meyer, Jutta, Pavkovic, Mira, Kretschmer, Axel, Lawrenz, Bettina, Hartmann, Elke, Mathar, Ilka, Hueser, Joerg, Kraehling, Jan R., Eitner, Frank, Hahn, Michael G., Stasch, Johannes-Peter, Sandner, Peter

“…Chronic kidney diseaQueryse (CKD) is associated with oxidative stress which can interrupt the nitric oxide (NO)/soluble guanylyl cyclase (sGC) signaling and…”
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The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats by Kraehling, Jan R, Benardeau, Agnes, Schomber, Tibor, Popp, Laura, Vienenkoetter, Julia, Ellinger-Ziegelbauer, Heidrun, Pavkovic, Mira, Hartmann, Elke, Siudak, Krystyna, Freyberger, Alexius, Hagelschuer, Ina, Mathar, Ilka, Hueser, Joerg, Hahn, Michael G, Geiss, Volker, Eitner, Frank, Sandner, Peter

“…Chronic kidney disease (CKD) progression is associated with persisting oxidative stress, which impairs the NO-sGC-cGMP signaling cascade through the formation…”
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NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin by Lehembre, Francois, Yilmaz, Mahmut, Wicki, Andreas, Schomber, Tibor, Strittmatter, Karin, Ziegler, Dominik, Kren, Angelika, Went, Phillip, Derksen, Patrick WB, Berns, Anton, Jonkers, Jos, Christofori, Gerhard

“…Loss of expression of the cell–cell adhesion molecule E‐cadherin is a hallmark of epithelial–mesenchymal transition (EMT) in development and in the progression…”
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Distinct Roles of Vascular Endothelial Growth Factor-D in Lymphangiogenesis and Metastasis by Kopfstein, Lucie, Veikkola, Tanja, Djonov, Valentin G, Baeriswyl, Vanessa, Schomber, Tibor, Strittmatter, Karin, Stacker, Steven A, Achen, Marc G, Alitalo, Kari, Christofori, Gerhard

“…In many human carcinomas, expression of the lymphangiogenic factor vascular endothelial growth factor-D (VEGF-D) correlates with up-regulated lymphangiogenesis…”
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Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis by Albrecht, Imke, Kopfstein, Lucie, Strittmatter, Karin, Schomber, Tibor, Falkevall, Annelie, Hagberg, Carolina E, Lorentz, Pascal, Jeltsch, Michael, Alitalo, Kari, Eriksson, Ulf, Christofori, Gerhard, Pietras, Kristian

“…The family of vascular endothelial growth factors (VEGF) contains key regulators of blood and lymph vessel development, including VEGF-A, -B, -C, -D, and…”
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Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis by Schomber, Tibor, Zumsteg, Adrian, Strittmatter, Karin, Crnic, Ivana, Antoniadis, Helena, Littlewood-Evans, Amanda, Wood, Jeanette, Christofori, Gerhard

“…Halting tumor growth by interfering with tumor-induced angiogenesis is an attractive therapeutic approach. Such treatments include humanized antibodies…”
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SOX9 interacts with a component of the human thyroid hormone receptor‐associated protein complex by Zhou, Rongjia, Bonneaud, Nathalie, Yuan, Chao‐Xing, de Santa Barbara, Pascal, Boizet, Brigitte, Tibor, Schomber, Scherer, Gerd, Roeder, Robert G., Poulat, Francis, Berta, Philippe

“…SOX9 transcription factor is involved in chondrocyte differentiation and male sex determination. Heterozygous defects in the human SOX9 gene cause campomelic…”
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Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice by Pan, Dejing, Schomber, Tibor, Kalberer, Christian P., Terracciano, Luigi M., Hafen, Katrin, Krenger, Werner, Hao-Shen, Hui, Deng, Chuxia, Skoda, Radek C.

“…The tumor suppressor Smad4 mediates signaling by the transforming growth factor beta (TGF-β) superfamily of ligands. Previous studies showed that several TGF-β…”
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Comparison of the CXCR5-Antibody Drug Conjugate (ADC; VIP924) to a CD19-ADC and a CD79b-ADC in a Humanized Rec-1 Mantle Cell Lymphoma (MCL) Mouse Model by Schomber, Tibor, Stelte-Ludwig, Beatrix, Rebstock, Anne-Sophie, v Ahsen, Oliver, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed

“…Introduction The chemokine receptor CXCR5 is highly expressed in MCL, which is a rare subtype of non-Hodgkin lymphoma. VIP924 is a first-in-class…”
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VIP943 Is a Novel CD123 Antibody Drug Conjugate with in Vitro and In Vivo Efficacy in Acute Myeloid Leukemia (AML) Models by Stelte-Ludwig, Beatrix, Clemens, George, Schomber, Tibor, Frigault, Melanie M., Johnson, Amy J., Lerchen, Hans-Georg, Izumi, Raquel, Hamdy, Ahmed

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Selectivity and Safety of VIP943: A Novel CD123-Targeting Antibody-Drug Conjugate (ADC) Using a Proprietary Linker and Payload Class by Stelte-Ludwig, Beatrix, Schomber, Tibor, Izumi, Raquel, Wong, Harvey, Frigault, Melanie M, Rebstock, Anne-Sophie, Ludwig, Sebastian, Mithal, Arushi, Johnson, Amy J, Hamdy, Ahmed

“…Introduction ADCs afford high efficacy though often have shortcomings in their safety profile. Most ADC payloads are cytotoxic agents that can inhibit general…”
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Assessment of Candidate Renal Protective Drug-Induced Biomarkers in Diabetic Kidney Disease Using Targeted Proteomic Profiling: PO0721 by Goea, Laura, Benardeau, Agnes M., Liu, Shuya, Lu, Shun, Ju, Wenjun, Eitner, Frank, Huber, Tobias B., Schomber, Tibor

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Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney by Stehle, Daniel, Xu, Min Ze, Schomber, Tibor, Hahn, Michael G., Schweda, Frank, Feil, Susanne, Kraehling, Jan R., Eitner, Frank, Patzak, Andreas, Sandner, Peter, Feil, Robert, Bénardeau, Agnès

“…Background and Purpose Generation of cGMP via NO‐sensitive soluble guanylyl cyclase (sGC) has been implicated in the regulation of renal functions. Chronic…”
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Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042) by Hahn, Michael G, Lampe, Thomas, El Sheikh, Sherif, Griebenow, Nils, Woltering, Elisabeth, Schlemmer, Karl-Heinz, Dietz, Lisa, Gerisch, Michael, Wunder, Frank, Becker-Pelster, Eva-Maria, Mondritzki, Thomas, Tinel, Hanna, Knorr, Andreas, Kern, Armin, Lang, Dieter, Hueser, Joerg, Schomber, Tibor, Benardeau, Agnes, Eitner, Frank, Truebel, Hubert, Mittendorf, Joachim, Kumar, Vijay, van den Akker, Focco, Schaefer, Martina, Geiss, Volker, Sandner, Peter, Stasch, Johannes-Peter

“…Herein we describe the discovery, mode of action, and preclinical characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC…”
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Runcaciguat, a Novel Soluble Guanylate Cyclase (sGC) Activator, Shows Kidney Protection in Models of CKD: SA-PO247 by Kraehling, Jan R., Schomber, Tibor, Benardeau, Agnes M., Kahnert, Antje, Popp, Laura, Vienenkoetter, Julia, Ellinger-Ziegelbauer, Heidrun C., Pavkovic, Mira, Kretschmer, Axel, Lawrenz, Bettina, Hartmann, Elke, Siudak, Krystyna, Freyberger, Alexius, Hagelschuer, Ina, Mathar, Ilka, Hüser, Jörg, Hahn, Michael G., Stasch, Johannes-Peter, Geiss, Volker, Eitner, Frank, Sandner, Peter

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The Novel Soluble Guanylyl Cyclase (sGC) Activator Runcaciguat Induced Renal Vasodilation and Reduced Kidney Damage in a Rat CKD Model: PO0600 by Benardeau, Agnes M., Hahn, Michael G., Gerisch, Michael, Meyer, Michaela, Menshykau, Dzianis, Hetzel, Terence, Schlender, Jan, Hartmann, Elke, Schomber, Tibor, Patzak, Andreas, Schweda, Frank, Kraehling, Jan R., Sandner, Peter, Eitner, Frank

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Abstract 484: VIP236: A small molecule drug conjugate with an optimized camptothecin payload has significant activity in patient-derived and metastatic cancer models by Stelte-Ludwig, Beatrix, Frigault, Melanie M., Lerchen, Hans-Georg, Schomber, Tibor, Izumi, Raquel, Johnson, Amy J., Hamdy, Ahmed

“…Abstract Introduction: We previously presented the design and preliminary characterization of VIP236—an SMDC consisting of an αvβ3 integrin binder linked to an…”
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Abstract 6294: CXCR5 is a very promising drug target for the development of antibody-drug conjugates to treat patients with lymphoma by Schomber, Tibor, Stelte-Ludwig, Beatrix, Johnson, Amy J., von Ahsen, Oliver, Schatz, Christoph, Izumi, Raquel, Hamdy, Ahmed, Lerchen, Hans-Georg

“…Abstract Introduction: The chemokine receptor CXCR5 is highly expressed in tumor cells from different lymphoma types and represents a viable drug target for…”
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Abstract 629: Activity of VIP943 on AML patient-derived leukemic blasts and healthy donor-derived bone marrow hematopoietic stem cells by Stelte-Ludwig, Beatrix, Schomber, Tibor, Frigault, Melanie M., Birkett, Joseph, Johnson, Amy J., Rebstock, Anne-Sophie, Ludwig, Sebastian, Izumi, Raquel, Hamdy, Ahmed

“…Abstract Introduction: In patients with acute myeloid leukemia (AML), CD123 has been shown to have high expression on blast cells and leukemic stem cells (LSC)…”
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