Search Results - "Schomaker, J."

Unexplored territory: Beneficial effects of novelty on memory by Schomaker, J.

“…•Exploration of spatially novel environments can enhance learning in animals.•Studies replicating these findings in humans are scarce.•The use of VR systems…”
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Short- and long-lasting consequences of novelty, deviance and surprise on brain and cognition by Schomaker, J, Meeter, M

“…When one encounters a novel stimulus this sets off a cascade of brain responses, activating several neuromodulatory systems. As a consequence novelty has a…”
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Predicting the unknown: Novelty processing depends on expectations by Schomaker, J., Meeter, M.

“…•The detection of expected novels was enhanced compared to unexpected novels.•The orienting response was reduced for expected compared to unexpected…”
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What I see is what I want: Top-down attention biasing choice behavior by Vriens, M., Vidden, C., Schomaker, J.

“…When making a purchasing decision, people typically scan the available options before deciding. Previous studies have shown that bottom-up stimulus-driven…”
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Effects of active exploration on novelty-related declarative memory enhancement by Schomaker, J., Wittmann, B.C.

“…•The role of volition on the effects of novelty on memory was investigated.•Participants either explored or were exposed to novel and familiar…”
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Novelty detection is enhanced when attention is otherwise engaged: an event-related potential study by Schomaker, J., Meeter, M.

“…Novel stimuli are detected and evaluated quickly, suggesting that processing them is a priority for the brain. In the present study, the effects of attention…”
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Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury by Krauskopf, Julian, Caiment, Florian, Claessen, Sandra M, Johnson, Kent J, Warner, Roscoe L, Schomaker, Shelli J, Burt, Deborah A, Aubrecht, Jiri, Kleinjans, Jos C

“…Drug-induced liver injury (DILI) is a leading cause of acute liver failure and the major reason for withdrawal of drugs from the market. Preclinical evaluation…”
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Novelty-induced memory boosts in humans: The when and how by Lorents, A., Ruitenberg, M.F.L., Schomaker, J.

“…Novel information potentially signals danger or reward and behavioral and psychophysiological studies have suggested that the brain prioritizes its processing…”
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Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse by Church, Rachel J, Schomaker, Shelli J, Eaddy, J Scott, Boucher, Germaine G, Kreeger, John M, Aubrecht, Jiri, Watkins, Paul B

“…Glutamate dehydrogenase (GLDH) is a liver-specific biomarker of hepatocellular damage currently undergoing qualification as a drug development tool. Since GLDH…”
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Food-related exploration across the menstrual cycle by Nijboer, A.C.S., Sellitto, M., Ruitenberg, M.F.L., Kerkkänen, K.I.L., Schomaker, J.

“…When deciding what to eat we constantly weigh different aspects of the options at hand and make trade-offs between exploiting opportunities with a known…”
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Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human by Krauskopf, Julian, de Kok, Theo M, Schomaker, Shelli J, Gosink, Mark, Burt, Deborah A, Chandler, Patricia, Warner, Roscoe L, Johnson, Kent J, Caiment, Florian, Kleinjans, Jos C, Aubrecht, Jiri

“…MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. We were…”
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Facilitation of responses by task-irrelevant complex deviant stimuli by Schomaker, J., Meeter, M.

“…Novel stimuli reliably attract attention, suggesting that novelty may disrupt performance when it is task-irrelevant. However, under certain circumstances…”
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Novelty processing depends on medial temporal lobe structures by Schomaker, J., Grouls, M.M.E., van der Linden, C.G.M., Rau, E.M., Hendriks, M., Colon, A., Meeter, M.

“…•The role of the medial temporal lobe (MTL) in novelty processing was investigated.•Epilepsy patients with MTL resections and controls performed a novelty…”
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1,3-Halogen migration as an entry to aryl coppers from an unintuitive starting material by Van Hoveln, R J, Schmid, S C, Schomaker, J M

“…A copper(I) catalyzed 1,3-halogen migration/borylation migrates a bromine from an sp(2) carbon to a benzylic carbon with concomitant borylation of the…”
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Formal Asymmetric Hydrobromination of Styrenes via Copper-Catalyzed 1,3-Halogen Migration by Van Hoveln, R J, Schmid, S C, Tretbar, M, Buttke, C T, Schomaker, J M

“…An enantioselective Cu(I)-catalyzed 1,3-halogen migration reaction accomplishes a formal hydrobromination by transferring a bromine activating group from a sp…”
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Novelty processing and memory formation in Parkinson's disease by SCHOMAKER, J, BERENDSE, H. W, FONCKE, E. M. J, VAN DER WERF, Y. D, VAN DEN HEUVEL, O. A, THEEUWES, J, MEETER, M

“…Parkinson's disease (PD) is characterized by a degeneration of nigrostriatal dopaminergic cells, resulting in dopamine depletion. This depletion is…”
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Arylation of Halogenated Pyrimidines via a Suzuki Coupling Reaction by Schomaker, Jennifer M, Delia, Thomas J

“…The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to…”
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The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies by Amacher, David E., Schomaker, Shelli J., Boldt, Sherri E., Mirsky, Michael

“…The purpose of this investigation was to examine the relationship among hepatic microsomal enzyme induction, liver weight, histological evidence of hepatic…”
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The Early Effects of Short-Term Dexamethasone Administration on Hepatic and Serum Alanine Aminotransferase in the Rat by Jackson, Elisa R., Kilroy, Carolyn, Joslin, Diane L., Schomaker, Shelli J., Pruimboom-Brees, Ingrid, Amacher, David E.

“…Dexamethasone (DEXA) administration has been associated with serum alanine aminotransferase (ALT) elevations that may result from enhanced ALT expression. The…”
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Evaluation of Rat Acute Phase Proteins as Inflammatory Biomarkers for Vaccine Nonclinical Safety Studies by Reagan, William J., Shoieb, Ahmed M., Schomaker, Shelli J., Markiewicz, Victoria R., Clarke, David W., Sellers, Rani S.

“…The objectives were to characterize the kinetics of acute phase proteins (APPs) α-2 macroglobulin (A2M), α-1 acid glycoprotein (A1AGP), and fibrinogen (FIB),…”
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