Search Results - "Scholze, Manuela"

Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors by Koch, Frederic, Scholze, Manuela, Wittler, Lars, Schifferl, Dennis, Sudheer, Smita, Grote, Phillip, Timmermann, Bernd, Macura, Karol, Herrmann, Bernhard G.

“…The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs)…”
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Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling by Rocha, Pedro P, Scholze, Manuela, Bleiss, Wilfrid, Schrewe, Heinrich

“…The Mediator complex is commonly seen as a molecular bridge that connects DNA-bound transcription factors to the RNA polymerase II (Pol II) machinery. It is a…”
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Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT‐Induced Presomitic Mesoderm by Sudheer, Smita, Liu, Jinhua, Marks, Matthias, Koch, Frederic, Anurin, Anna, Scholze, Manuela, Senft, Anna Dorothea, Wittler, Lars, Macura, Karol, Grote, Phillip, Herrmann, Bernhard G.

“…Presomitic mesoderm (PSM) cells are the precursors of the somites, which flank both sides of the neural tube and give rise to the musculo‐skeletal system…”
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Vasorin-deficient mice display disturbed vitamin D and mineral homeostasis in combination with a low bone mass phenotype by Eijken, Marco, Krautzberger, A. Michaela, Scholze-Wittler, Manuela, Boers-Sijmons, Bianca, Koedam, Marijke, Kosiol, Barbara, Schrewe, Heinrich, van Leeuwen, Johannes P., van der Eerden, Bram C.

“…Vasorin (Vasn) is a pleiotropic molecule involved in various physiological and pathological conditions, including cancer. Vasn has also been detected in bone…”
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A gene expression map of human chromosome 21 orthologues in the mouse by Gitton, Yorick, Dahmane, Nadia, Baik, Sonya, Ruiz i Altaba, Ariel, Neidhardt, Lorenz, Scholze, Manuela, Herrmann, Bernhard G, Kahlem, Pascal, Benkahla, Alia, Schrinner, Sabine, Yildirimman, Reha, Herwig, Ralf, Lehrach, Hans, Yaspo, Marie-Laure

“…The DNA sequence of human chromosome 21 (HSA21) has opened the route for a systematic molecular characterization of all of its genes. Trisomy 21 is associated…”
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Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency by Segal, Joanna, Mülleder, Michael, Krüger, Antje, Adler, Thure, Scholze‐Wittler, Manuela, Becker, Lore, Calzada‐Wack, Julia, Garrett, Lillian, Hölter, Sabine M., Rathkolb, Birgit, Rozman, Jan, Racz, Ildiko, Fischer, Ralf, Busch, Dirk H., Neff, Frauke, Klingenspor, Martin, Klopstock, Thomas, Grüning, Nana‐Maria, Michel, Steve, Lukaszewska‐McGreal, Beata, Voigt, Ingo, Hartmann, Ludger, Timmermann, Bernd, Lehrach, Hans, Wolf, Eckhard, Wurst, Wolfgang, Gailus‐Durner, Valérie, Fuchs, Helmut, H. de Angelis, Martin, Schrewe, Heinrich, Yuneva, Mariia, Ralser, Markus

“…Triosephosphate isomerase (TPI) deficiency is a fatal genetic disorder characterized by hemolytic anemia and neurological dysfunction. Although the enzyme…”
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Expression of vasorin (Vasn) during embryonic development of the mouse by Krautzberger, A. Michaela, Kosiol, Barbara, Scholze, Manuela, Schrewe, Heinrich

“…► We generated a vasorin (Vasn) reporter knock-in mouse model to analyze Vasn gene expression. ► We confirmed that reporter expression faithfully reflects…”
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Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites by Veenvliet, Jesse V, Bolondi, Adriano, Kretzmer, Helene, Haut, Leah, Scholze-Wittler, Manuela, Schifferl, Dennis, Koch, Frederic, Guignard, Léo, Kumar, Abhishek Sampath, Pustet, Milena, Heimann, Simon, Buschow, René, Wittler, Lars, Timmermann, Bernd, Meissner, Alexander, Herrmann, Bernhard G

“…Post-implantation embryogenesis is a highly dynamic process comprising multiple lineage decisions and morphogenetic changes that are inaccessible to deep…”
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SRF promotes long-range chromatin loop formation and stem cell pluripotency by Tsaytler, Pavel, Blaess, Gaby, Scholze-Wittler, Manuela, Meierhofer, David, Wittler, Lars, Koch, Frederic, Herrmann, Bernhard G.

“…Serum response factor (SRF) is a transcription factor essential for cell proliferation, differentiation, and migration and is required for primitive streak and…”
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Early neural specification of stem cells is mediated by a set of SOX2-dependent neural-associated enhancers by Tsaytler, Pavel, Blaess, Gaby, Scholze-Wittler, Manuela, Koch, Frederic, Herrmann, Bernhard G.

“…SOX2 is a transcription factor involved in the regulatory network maintaining the pluripotency of embryonic stem cells in culture as well as in early embryos…”
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A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development by Schifferl, Dennis, Scholze-Wittler, Manuela, Wittler, Lars, Veenvliet, Jesse V, Koch, Frederic, Herrmann, Bernhard G

“…The node-streak border region comprising notochord progenitor cells (NPCs) at the posterior node and neuro-mesodermal progenitor cells (NMPs) in the adjacent…”
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Genome-wide identification of notochord enhancers comprising the regulatory landscape of the brachyury locus in mouse by Schifferl, Dennis, Scholze-Wittler, Manuela, Villaronga Luque, Alba, Pustet, Milena, Wittler, Lars, Veenvliet, Jesse V., Koch, Frederic, Herrmann, Bernhard G.

“…The node and notochord are important signaling centers organizing the dorso-ventral patterning of cells arising from neuro-mesodermal progenitors forming the…”
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