Search Results - "Scholz, Thomas D."

Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice by Roghair, Robert D, Wemmie, John A, Volk, Kenneth A, Scholz, Thomas D, Lamb, Fred S, Segar, Jeffrey L

“…Intra-uterine growth restriction is an independent risk factor for adult psychiatric and cardiovascular diseases. In humans, intra-uterine growth restriction…”
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Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats by Segar, Emily M, Norris, Andrew W, Yao, Jian-Rong, Hu, Shanming, Koppenhafer, Stacia L, Roghair, Robert D, Segar, Jeffrey L, Scholz, Thomas D

“…ODM (offspring of diabetic mothers) have an increased risk of developing metabolic and cardiovascular dysfunction; however, few studies have focused on the…”
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Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice by Roghair, Robert D, Segar, Jeffrey L, Volk, Kenneth A, Chapleau, Mark W, Dallas, Lindsay M, Sorenson, Anna R, Scholz, Thomas D, Lamb, Fred S

“…Intrauterine environmental pertubations have been linked to the development of adult hypertension. We sought to evaluate the interrelated roles of sex, nitric…”
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CaMKII determines mitochondrial stress responses in heart by Joiner, Mei-ling A., Koval, Olha M., Li, Jingdong, He, B. Julie, Allamargot, Chantal, Gao, Zhan, Luczak, Elizabeth D., Hall, Duane D., Fink, Brian D., Chen, Biyi, Yang, Jinying, Moore, Steven A., Scholz, Thomas D., Strack, Stefan, Mohler, Peter J., Sivitz, William I., Song, Long-Sheng, Anderson, Mark E.

“…Calcium exchange and cardiac stress Increased mitochondrial calcium entry has been implicated in myocardial death, heart failure and related conditions. Here,…”
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Recruitment of NADH shuttling in pressure-overloaded and hypertrophic rat hearts by Lewandowski, E Douglas, O'donnell, J Michael, Scholz, Thomas D, Sorokina, Natalia, Buttrick, Peter M

“…Glucose metabolism in the heart requires oxidation of cytosolic NADH from glycolysis. This study examines shuttling reducing equivalents from the cytosol to…”
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4-D Cardiac MR Image Analysis: Left and Right Ventricular Morphology and Function by Honghai Zhang, Wahle, A., Johnson, R.K., Scholz, T.D., Sonka, M.

“…In this study, a combination of active shape model (ASM) and active appearance model (AAM) was used to segment the left and right ventricles of normal and…”
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Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways by Reinking, Benjamin E, Wedemeyer, Elesa W, Weiss, Robert M, Segar, Jeffrey L, Scholz, Thomas D

“…Maternal diabetes affects the developing fetal cardiovascular system. Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We…”
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Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene by Zinkhan, Erin K., Fu, Qi, Wang, Yan, Yu, Xing, Callaway, Christopher W., Segar, Jeffrey L., Scholz, Thomas D., McKnight, Robert A., Joss-Moore, Lisa A., Lane, Robert H.

“…In utero environmental adaptation may predispose to lifelong morbidity. Organisms fine-tune gene expression to achieve environmental adaptation by epigenetic…”
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Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria by von Bergen, Nicholas H, Koppenhafer, Stacia L, Spitz, Douglas R, Volk, Kenneth A, Patel, Sonali S, Roghair, Robert D, Lamb, Fred S, Segar, Jeffrey L, Scholz, Thomas D

“…Exposure to an adverse intrauterine environment is recognized as an important risk factor for the development of cardiovascular disease later in life. Although…”
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UCP2-dependent Proton Leak in Isolated Mammalian Mitochondria by Fink, Brian D., Hong, Young-Sun, Mathahs, Mary M., Scholz, Thomas D., Dillon, Joseph S., Sivitz, William I.

“…A role for uncoupling protein (UCP) homologues in mediating the proton leak in mammalian mitochondria is controversial. We subjected insulinoma (INS-1) cells…”
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ANG II modulation of cardiac growth and remodeling in immature fetal sheep by Sandgren, Jeremy, Scholz, Thomas D, Segar, Jeffrey L

“…ANG II increases fetal blood pressure and stimulates fetal heart growth; however, little is known regarding its direct effects on cardiomyocytes in vivo. We…”
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Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism by Ralphe, J Carter, Bedell, Kurt, Segar, Jeffrey L, Scholz, Thomas D

“…In the heart, elevated thyroid hormone leads to upregulation of metabolic pathways associated with energy production and development of hypertrophy. The…”
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Metabolic adaptation of the fetal and postnatal ovine heart: Regulatory role of hypoxia-inducible factors and nuclear respiratory factor-1 by NAU, Peter N, VAN NATTA, Timothy, CARTER RALPHE, J, TENEYCK, Cynthia J, BEDELL, Kurt A, CALDARONE, Christopher A, SEGAR, Jeffrey L, SCHOLZ, Thomas D

“…Numerous metabolic adaptations occur in the heart after birth. Important transcription factors that regulate expression of the glycolytic and mitochondrial…”
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Sex-specific programming of hypertension in offspring of late-gestation diabetic rats by Katkhuda, Ragheed, Peterson, Emily S., Roghair, Robert D., Norris, Andrew W., Scholz, Thomas D., Segar, Jeffrey L.

“…Background: The intrauterine environment strongly influences adult disease susceptibility. We used a rat model of third-trimester maternal diabetes to test the…”
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Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging by Bartlett, Heather L, Scholz, Thomas D, Lamb, Fred S, Weeks, Daniel L

“…Congenital heart defects often include altered conduction as well as morphological changes. Model organisms, like the frog Xenopus laevis, offer practical…”
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Congenital aortic disease: 4D magnetic resonance segmentation and quantitative analysis by Zhao, Fei, Zhang, Honghai, Wahle, Andreas, Thomas, Matthew T., Stolpen, Alan H., Scholz, Thomas D., Sonka, Milan

“…Automated and accurate segmentation of the aorta in 4D (3D+time) cardiovascular magnetic resonance (MR) image data is important for early detection of…”
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Prepregnancy exposure to dietary arsenic and congenital heart defects by Suhl, Jonathan, Conway, Kristin M., Rhoads, Anthony, Langlois, Peter H., Feldkamp, Marcia L., Michalski, Adrian M., Oleson, Jacob, Sidhu, Alpa, Scholz, Thomas D., Kancherla, Vijaya, Obrycki, John, Mazumdar, Maitreyi, Romitti, Paul A.

“…Introduction Arsenic crosses the placenta and accumulates in fetal tissues. In the United States, diet is the predominant route of arsenic exposure, but…”
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Influenza vaccination during pregnancy and risk of selected major structural congenital heart defects, National Birth Defects Prevention Study 2006–2011 by Palmsten, Kristin, Suhl, Jonathan, Conway, Kristin M., Kharbanda, Elyse O., Scholz, Thomas D., Ailes, Elizabeth C., Cragan, Janet D., Nestoridi, Eirini, Papadopoulos, Eleni A., Kerr, Stephen M., Young, Sean G., Olson, Christine, Romitti, Paul A.

“…Background Although results from studies of first‐trimester influenza vaccination and congenital heart defects (CHDs) have been reassuring, data are limited…”
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Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart by Segar, Jeffrey L., Volk, Ken A., Lipman, Michael H. B., Scholz, Thomas D.

“…New Findings •  What is the central question of this study? The importance of endogenous thyroid hormone in contributing to pathophysiological adaptive growth…”
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Transfusion Effects on Cardiomyocyte Growth and Proliferation in Fetal Sheep After Chronic Anemia by Jonker, Sonnet S, Scholz, Thomas D, Segar, Jeffrey L

“…Chronic fetal anemia results in significant cardiac remodeling. The capacity to reverse these effects is unknown. We examined the effects of transfusion on…”
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