Search Results - "Scholz, L."

The influence of heart developmental anatomy on cardiotoxicity-based adverse outcome pathways in fish by Incardona, John P., Scholz, Nathaniel L.

“…The developing fish heart is vulnerable to a diverse array of toxic chemical contaminants in freshwater, estuarine, and marine habitats. Globally occurring…”
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A ubiquitous tire rubber-derived chemical induces acute mortality in coho salmon by Tian, Zhenyu, Zhao, Haoqi, Peter, Katherine T, Gonzalez, Melissa, Wetzel, Jill, Wu, Christopher, Hu, Ximin, Prat, Jasmine, Mudrock, Emma, Hettinger, Rachel, Cortina, Allan E, Biswas, Rajshree Ghosh, Kock, Flávio Vinicius Crizóstomo, Soong, Ronald, Jenne, Amy, Du, Bowen, Hou, Fan, He, Huan, Lundeen, Rachel, Gilbreath, Alicia, Sutton, Rebecca, Scholz, Nathaniel L, Davis, Jay W, Dodd, Michael C, Simpson, Andre, McIntyre, Jenifer K, Kolodziej, Edward P

“…In U.S. Pacific Northwest coho salmon ( ), stormwater exposure annually causes unexplained acute mortality when adult salmon migrate to urban creeks to…”
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Using High-Resolution Mass Spectrometry to Identify Organic Contaminants Linked to Urban Stormwater Mortality Syndrome in Coho Salmon by Peter, Katherine T, Tian, Zhenyu, Wu, Christopher, Lin, Peter, White, Sarah, Du, Bowen, McIntyre, Jenifer K, Scholz, Nathaniel L, Kolodziej, Edward P

“…Urban stormwater is a major threat to ecological health, causing a range of adverse, mostly sublethal effects. In western North America, urban runoff is…”
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Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish by Brette, Fabien, Machado, Ben, Cros, Caroline, Incardona, John P., Scholz, Nathaniel L., Block, Barbara A.

“…Crude oil is known to disrupt cardiac function in fish embryos. Large oil spills, such as the Deepwater Horizon (DWH) disaster that occurred in 2010 in the…”
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A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice by Hao, Yi, O'Neill, Patrick, Naradikian, Martin S., Scholz, Jean L., Cancro, Michael P.

“…We have discovered a distinct mature B-cell subset that accumulates with age, which we have termed age-associated B cells. These cells comprise up to 30% of…”
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Photoacoustic-based detector for infrared laser spectroscopy by Scholz, L., Palzer, S.

“…In this contribution, we present an alternative detector technology for use in direct absorption spectroscopy setups. Instead of a semiconductor based…”
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Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development by Incardona, John P., Linbo, Tiffany L., Scholz, Nathaniel L.

“…Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs), commonly occur as complex mixtures in the environment. Recent studies using the…”
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The Synergistic Toxicity of Pesticide Mixtures: Implications for Risk Assessment and the Conservation of Endangered Pacific Salmon by Laetz, Cathy A., Baldwin, David H., Collier, Tracy K., Hebert, Vincent, Stark, John D., Scholz, Nathaniel L.

“…Background: Mixtures of organophosphate and carbamate pesticides are commonly detected in freshwater habitats that support threatened and endangered species of…”
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Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish by Incardona, John P, Gardner, Luke D, Linbo, Tiffany L, Brown, Tanya L, Esbaugh, Andrew J, Mager, Edward M, Stieglitz, John D, French, Barbara L, Labenia, Jana S, Laetz, Cathy A, Tagal, Mark, Sloan, Catherine A, Elizur, Abigail, Benetti, Daniel D, Grosell, Martin, Block, Barbara A, Scholz, Nathaniel L

“…The Deepwater Horizon disaster released more than 636 million L of crude oil into the northern Gulf of Mexico. The spill oiled upper surface water spawning…”
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MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development by O'Connell, Ryan M., Kahn, Daniel, Gibson, William S.J., Round, June L., Scholz, Rebecca L., Chaudhuri, Aadel A., Kahn, Melissa E., Rao, Dinesh S., Baltimore, David

“…Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of…”
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Interspecies variation in the susceptibility of adult Pacific salmon to toxic urban stormwater runoff by McIntyre, Jenifer K., Lundin, Jessica I., Cameron, James R., Chow, Michelle I., Davis, Jay W., Incardona, John P., Scholz, Nathaniel L.

“…Adult coho salmon (Oncorhynchus kisutch) prematurely die when they return from the ocean to spawn in urban watersheds throughout northwestern North America…”
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Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish by Hicken, Corinne E, Linbo, Tiffany L, Baldwin, David H, Willis, Maryjean L, Myers, Mark S, Holland, Larry, Larsen, Marie, Stekoll, Michael S, Rice, Stanley D, Collier, Tracy K, Scholz, Nathaniel L, Incardona, John P

“…Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic…”
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Editorial: Evolution of Innate Immunity in Eukarya: Advances and Implications by Scholz, Jean L, Eleftherianos, Ioannis, Kobe, Bostjan

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Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish by Sørhus, Elin, Incardona, John P, Furmanek, Tomasz, Goetz, Giles W, Scholz, Nathaniel L, Meier, Sonnich, Edvardsen, Rolf B, Jentoft, Sissel

“…Crude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe…”
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Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons by Incardona, John P., Collier, Tracy K., Scholz, Nathaniel L.

“…Fish embryos exposed to complex mixtures of polycyclic aromatic hydrocarbons (PAHs) from petrogenic sources show a characteristic suite of abnormalities,…”
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Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism by Incardona, John P., Day, Heather L., Collier, Tracy K., Scholz, Nathaniel L.

“…Polycyclic aromatic hydrocarbons (PAHs) derived from fossil fuels are ubiquitous contaminants and occur in aquatic habitats as highly variable and complex…”
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A comparative review of aging and B cell function in mice and humans by Scholz, Jean L, Diaz, Alain, Riley, Richard L, Cancro, Michael P, Frasca, Daniela

“…Highlights • B cell generation in bone marrow declines with age in mice but may be maintained in humans. • Shifts in naïve and antigen-experienced peripheral B…”
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Coho salmon spawner mortality in western US urban watersheds: bioinfiltration prevents lethal storm water impacts by Spromberg, Julann A., Baldwin, David H., Damm, Steven E., Mclntyre, Jenifer K., Huff, Michael, Sloan, Catherine A., Anulacion, Bernadita F., Davis, Jay W., Scholz, Nathaniel L.

“…1. Adult coho salmon Oncorhynchus kisutch return each autumn to freshwater spawning habitats throughout western North America. The migration coincides with…”
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Elevated temperatures increase the toxicity of pesticide mixtures to juvenile coho salmon by Laetz, Cathy A., Baldwin, David H., Hebert, Vincent R., Stark, John D., Scholz, Nathaniel L.

“…•Juvenile coho salmon were exposed to pesticide mixtures at varying temperatures.•Increasing temperature enhanced insecticide mixture neurotoxicity.•Chemical…”
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Neural defects and cardiac arrhythmia in fish larvae following embryonic exposure to 2,2′,4,4′-tetrabromodiphenyl ether (PBDE 47) by Lema, Sean C., Schultz, Irvin R., Scholz, Nathaniel L., Incardona, John P., Swanson, Penny

“…Polybrominated diphenyl ethers (PBDEs) are added to plastics, polyurethane foam, and textiles as a flame retardant. While PBDEs play a key role in reducing…”
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