Search Results - "Scholz, Guido"
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Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays
Published in Journal of medicinal chemistry (25-07-2024)“…Identifying promising chemical starting points for small molecule inhibitors of active, GTP-loaded KRAS “on” remains of great importance to clinical oncology…”
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Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis
Published in Journal of medicinal chemistry (12-09-2019)“…Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived…”
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Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
Published in Nature cancer (01-07-2022)Get full text
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Plasma Concentrations and Analgesic Effects of Ropivacaine 3.75 mg/mL During Long-Term Extrapleural Analgesia After Thoracotomy
Published in Regional anesthesia and pain medicine (01-07-2005)“…Fourteen patients received long-term extrapleural analgesia with ropivacaine for postoperative pain relief after posterolateral thoracotomy. We determined…”
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