Search Results - "Scholz, Carsten C."

The effect of HIF on metabolism and immunity by Taylor, Cormac T., Scholz, Carsten C.

“…Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to produce the levels of ATP required to perform physiological functions exceeds…”
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Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function by Kelly, Caleb J., Zheng, Leon, Campbell, Eric L., Saeedi, Bejan, Scholz, Carsten C., Bayless, Amanda J., Wilson, Kelly E., Glover, Louise E., Kominsky, Douglas J., Magnuson, Aaron, Weir, Tiffany L., Ehrentraut, Stefan F., Pickel, Christina, Kuhn, Kristine A., Lanis, Jordi M., Nguyen, Vu, Taylor, Cormac T., Colgan, Sean P.

“…Interactions between the microbiota and distal gut are fundamental determinants of human health. Such interactions are concentrated at the colonic mucosa and…”
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Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways by Scholz, Carsten C., Cavadas, Miguel A. S., Tambuwala, Murtaza M., Hams, Emily, Rodríguez, Javier, von Kriegsheim, Alex, Cotter, Philip, Bruning, Ulrike, Fallon, Padraic G., Cheong, Alex, Cummins, Eoin P., Taylor, Cormac T.

“…Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the…”
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Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype by Imeri, Faik, Nolan, Karen A, Bapst, Andreas M, Santambrogio, Sara, Abreu-Rodríguez, Irene, Spielmann, Patrick, Pfundstein, Svende, Libertini, Silvana, Crowther, Lisa, Orlando, Ilaria M C, Dahl, Sophie L, Keodara, Anna, Kuo, Willy, Kurtcuoglu, Vartan, Scholz, Carsten C, Qi, Weihong, Hummler, Edith, Hoogewijs, David, Wenger, Roland H

“…Erythropoietin (Epo) is essential for erythropoiesis and is mainly produced by the fetal liver and the adult kidney following hypoxic stimulation. Epo…”
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FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1 by Scholz, Carsten C, Rodriguez, Javier, Pickel, Christina, Burr, Stephen, Fabrizio, Jacqueline-Alba, Nolan, Karen A, Spielmann, Patrick, Cavadas, Miguel A S, Crifo, Bianca, Halligan, Doug N, Nathan, James A, Peet, Daniel J, Wenger, Roland H, Von Kriegsheim, Alex, Cummins, Eoin P, Taylor, Cormac T

“…The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular…”
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A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network by Nguyen, Lan K, Cavadas, Miguel A S, Scholz, Carsten C, Fitzpatrick, Susan F, Bruning, Ulrike, Cummins, Eoin P, Tambuwala, Murtaza M, Manresa, Mario C, Kholodenko, Boris N, Taylor, Cormac T, Cheong, Alex

“…Activation of the hypoxia-inducible factor (HIF) pathway is a critical step in the transcriptional response to hypoxia. Although many of the key proteins…”
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REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia by Cavadas, Miguel A. S., Mesnieres, Marion, Crifo, Bianca, Manresa, Mario C., Selfridge, Andrew C., Scholz, Carsten C., Cummins, Eoin P., Cheong, Alex, Taylor, Cormac T.

“…The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen…”
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REST is a hypoxia-responsive transcriptional repressor by Cavadas, Miguel A. S., Mesnieres, Marion, Crifo, Bianca, Manresa, Mario C., Selfridge, Andrew C., Keogh, Ciara E., Fabian, Zsolt, Scholz, Carsten C., Nolan, Karen A., Rocha, Liliane M. A., Tambuwala, Murtaza M., Brown, Stuart, Wdowicz, Anita, Corbett, Danielle, Murphy, Keith J., Godson, Catherine, Cummins, Eoin P., Taylor, Cormac T., Cheong, Alex

“…Cellular exposure to hypoxia results in altered gene expression in a range of physiologic and pathophysiologic states. Discrete cohorts of genes can be either…”
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The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism by Ruiz-Serrano, Amalia, Boyle, Christina N, Monné Rodríguez, Josep M, Günter, Julia, Jucht, Agnieszka E, Pfundstein, Svende, Bapst, Andreas M, Lutz, Thomas A, Wenger, Roland H, Scholz, Carsten C

“…Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic…”
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Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1 by Pickel, Christina, Günter, Julia, Ruiz-Serrano, Amalia, Spielmann, Patrick, Fabrizio, Jacqueline-Alba, Wolski, Witold, Peet, Daniel J, Wenger, Roland H, Scholz, Carsten C

“…Protein:protein interactions are the basis of molecular communication and are usually of transient non-covalent nature, while covalent interactions other than…”
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Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia by Agbor, Terence A., Cheong, Alex, Comerford, Katrina M., Scholz, Carsten C., Bruning, Ulrike, Clarke, Ambrose, Cummins, Eoin P., Cagney, Gerard, Taylor, Cormac T.

“…Under conditions of hypoxia, most eukaryotic cells undergo a shift in metabolic strategy, which involves increased flux through the glycolytic pathway…”
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Hypoxia in chronic kidney disease: towards a paradigm shift? by Faivre, Anna, Scholz, Carsten C., de Seigneux, Sophie

“…Abstract Chronic kidney disease (CKD) is defined as an alteration of kidney structure and/or function lasting for >3 months [1]. CKD affects 10% of the general…”
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PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions by Jucht, Agnieszka E., Scholz, Carsten C.

“…Oxygen sensors enable cells to adapt to limited oxygen availability (hypoxia), affecting various cellular and tissue responses. Prolyl-4-hydroxylase domain 1–3…”
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Targeting the HIF pathway in inflammation and immunity by Scholz, Carsten C, Taylor, Cormac T

“…Highlights • Hypoxia is a prominent feature in inflamed tissues. • The HIF pathway is a potential therapeutic target in inflammation. • Hydroxylase inhibition…”
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The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor by Volkova, Yulia L, Pickel, Christina, Jucht, Agnieszka E, Wenger, Roland H, Scholz, Carsten C

“…Limited oxygen availability (hypoxia) commonly occurs in a range of physiological and pathophysiological conditions, including embryonic development, physical…”
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Oxomer- and Reporter Gene-Based Analysis of FIH Activity in Cells by Volkova, Yulia L, Jucht, Agnieszka E, Scholz, Carsten C

“…Cellular and tissue adaptations to oxygen deprivation (hypoxia) are necessary for both normal physiology and disease. Responses to hypoxia are initiated by the…”
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Fount, fate, features, and function of renal erythropoietin-producing cells by Dahl, Sophie L., Bapst, Andreas M., Khodo, Stellor Nlandu, Scholz, Carsten C., Wenger, Roland H.

“…Renal erythropoietin (Epo)-producing (REP) cells represent a rare and incompletely understood cell type. REP cells are fibroblast-like cells located in close…”
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Inhibition of firefly luciferase activity by a HIF prolyl hydroxylase inhibitor by Günter, Julia, Wenger, Roland H., Scholz, Carsten C.

“…The three hypoxia-inducible factor (HIF) prolyl-4-hydroxylase domain (PHD) 1–3 enzymes confer oxygen sensitivity to the HIF pathway and are novel therapeutic…”
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Thermomechanical properties of bat and human red blood cells-Implications for hibernation by Fregin, Bob, Hossain, Mohammed Faruq, Biedenweg, Doreen, Friedrichs, Virginia, Balkema-Buschmann, Anne, Bokelmann, Marcel, Lehnert, Kristin, Mokbel, Dominic, Aland, Sebastian, Scholz, Carsten C, Lehmann, Philipp, Otto, Oliver, Kerth, Gerald

“…Hibernation is a widespread and highly efficient mechanism to save energy in mammals. However, one major challenge of hibernation is maintaining blood…”
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MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1α Activity during Prolonged Hypoxia by Bruning, Ulrike, Cerone, Luca, Neufeld, Zoltan, Fitzpatrick, Susan F., Cheong, Alex, Scholz, Carsten C., Simpson, David A., Leonard, Martin O., Tambuwala, Murtaza M., Cummins, Eoin P., Taylor, Cormac T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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