Search Results - "Scholman, Koen"

Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction by van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Houweling, Arjan C., Scholman, Koen T., Wakker, Vincent, Allaart, Cornelis P., Uhm, Jae-Sun, Mathijssen, Inge B., Baartscheer, Ton, Postma, Alex V., Barnett, Phil, Verkerk, Arie O., Boukens, Bastiaan J., Christoffels, Vincent M.

“…The pathogenic missense variant p.G125R in TBX5 (T-box transcription factor 5) causes Holt-Oram syndrome (also known as hand-heart syndrome) and early onset of…”
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Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury by Lacraz, Grégory P.A, Junker, Jan Philipp, Gladka, Monika M, Molenaar, Bas, Scholman, Koen T, Vigil-Garcia, Marta, Versteeg, Danielle, de Ruiter, Hesther, Vermunt, Marit W, Creyghton, Menno P, Huibers, Manon M.H, de Jonge, Nicolaas, van Oudenaarden, Alexander, van Rooij, Eva

“…BACKGROUND:Cardiac ischemic injury induces a pathological remodeling response, which can ultimately lead to heart failure. Detailed mechanistic insights into…”
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Identification of atrial fibrillation associated genes and functional non-coding variants by van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Hill, Matthew C., Montefiori, Lindsey E., Scholman, Koen T., Liu, Jia, de Vries, Antoine A. F., Boukens, Bastiaan J., Ellinor, Patrick T., Goumans, Marie José T. H., Efimov, Igor R., Nobrega, Marcelo A., Barnett, Phil, Martin, James F., Christoffels, Vincent M.

“…Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of…”
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Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction by Man, Joyce C.K., Bosada, Fernanda M., Scholman, Koen T., Offerhaus, Joost A., Walsh, Roddy, van Duijvenboden, Karel, van Eif, Vincent W.W., Bezzina, Connie R., Verkerk, Arie O., Boukens, Bastiaan J., Barnett, Phil, Christoffels, Vincent M.

“…Genetic variants in , encoding the neuronal voltage-gated sodium channel Na 1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac…”
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From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity by Scholman, Koen T., Meijborg, Veronique M. F., Gálvez-Montón, Carolina, Lodder, Elisabeth M., Boukens, Bastiaan J.

“…Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias…”
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Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel by Veldkamp, Marieke W., Geuzebroek, Guillaume S. C., Baartscheer, Antonius, Verkerk, Arie O., Schumacher, Cees A., Suarez, Gedeon G., Berger, Wouter R., Casini, Simona, van Amersfoorth, Shirley C. M., Scholman, Koen T., Driessen, Antoine H. G., Belterman, Charly N. W., van Ginneken, Antoni C. G., de Groot, Joris R., de Bakker, Jacques M. T., Remme, Carol Ann, Boukens, Bas J., Coronel, Ruben

“…The cardiac autonomic nervous system (ANS) controls normal atrial electrical function. The cardiac ANS produces various neuropeptides, among which the…”
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Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo by de Bruin, Alain, A Cornelissen, Peter W, Kirchmaier, Bettina C, Mokry, Michal, Iich, Elhadi, Nirmala, Ella, Liang, Kuo-Hsuan, D Végh, Anna M, Scholman, Koen T, Groot Koerkamp, Marian J, Holstege, Frank C, Cuppen, Edwin, Schulte-Merker, Stefan, Bakker, Walbert J

“…In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is…”
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PO-05-006 THE RIGHT VENTRICULAR OUTFLOW TRACT DISPLAYS A SMALL L-TYPE CALCIUM CURRENT AND TRANSIENT AMPLITUDE DUE TO A UNIQUE GENE EXPRESSION PROFILE INVOLVING SYT1 by Blok, Michiel, Rivaud, Mathilde, van Wijk, Stan, Scholman, Koen T., Schumacher, Cees A., Jongbloed, Monique R., Brundel, Bianca, Coronel, Ruben, Bosada, Fernanda M., Baartscheer, Antonius, Verkerk, Arie O., Veldkamp, Marieke W., Boukens, Bas J.

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Abstract P3-03-18: M1 registration: Signaling patients who develop metachronous metastases after primary breast cancer by de Munck, Linda, Knoors, Daan, Buisman, Harm, Scholman, Koen, Verloop, Janneke, Siesling, Sabine

“…Abstract Background At the moment, over 180,000 breast cancer survivors are living in the Netherlands and survival after a breast cancer diagnosis and…”
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Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction by van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Houweling, Arjan C., Scholman, Koen T., Wakker, Vincent, Allaart, Cornelis P., Uhm, Jae-Sun, Mathijssen, Inge B, Baartscheer, Ton, Postma, Alex V., Barnett, Phil, Verkerk, Arie O., Boukens, Bastiaan J., Christoffels, Vincent M.

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Abstract 373: Spatial Expression Analysis of the Ischemic Heart Identifies Novel Factors Involved in Cardiac Remodeling and Disease by Lacraz, Gregory, Junker, Jan Philipp, Scholman, Koen, Versteeg, Danielle, van Oudenaarden, Alexander, van Rooij, Eva

“…Abstract only Cardiac ischemic injury is associated with expressional changes in a broad range of coding and non-coding genes. While genome-wide expression…”
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α 1 -adrenergic stimulation increases ventricular action potential duration in the intact mouse heart by Joyce, William, Scholman, Koen T., Jensen, Bjarke, Wang, Tobias, Boukens, Bastiaan J.

“…The role of α 1 -adrenergic receptors (α-ARs) in the regulation of myocardial function is less well-understood than that of β-ARs. Previous reports in the…”
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α1-adrenergic stimulation increases ventricular action potential duration in the intact mouse heart by William Joyce, Koen T. Scholman, Bjarke Jensen, Tobias Wang, Bastiaan J. Boukens

“…The role of α1-adrenergic receptors (α-ARs) in the regulation of myocardial function is less well-understood than that of β-ARs. Previous reports in the mouse…”
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