Search Results - "Scholey, James W."

Kidney ACE2 expression: Implications for chronic kidney disease by Maksimowski, Nicholas, Williams, Vanessa R, Scholey, James W

“…Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of chronic kidney disease (CKD) and is a membrane receptor for severe acute…”
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Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice by Zhao, Shuiling, Ghosh, Anindya, Lo, Chao-Sheng, Chenier, Isabelle, Scholey, James W, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S D

“…Abstract We investigated the role of nuclear factor erythroid 2–related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal…”
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Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion by Paradis, Stéphanie, Charles, Anne-Laure, Meyer, Alain, Lejay, Anne, Scholey, James W, Chakfé, Nabil, Zoll, Joffrey, Geny, Bernard

“…Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries that reduces functional capacity and quality of life of patients…”
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Remission of Proteinuria Improves Prognosis in IgA Nephropathy by REICH, Heather N, TROYANOV, Stéphan, SCHOLEY, James W, CATTRAN, Daniel C

“…Proteinuria has been shown to be an adverse prognostic factor in IgA nephropathy. The benefit of achieving a partial remission of proteinuria, however, has not…”
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Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2 by Zhong, JiuChang, Guo, Danny, Chen, Christopher B, Wang, Wang, Schuster, Manfred, Loibner, Hans, Penninger, Josef M, Scholey, James W, Kassiri, Zamaneh, Oudit, Gavin Y

“…Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase capable of metabolizing angiotensin (Ang) II into Ang 1 to 7. We hypothesized that ACE2 is a…”
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Sex and kidney ACE2 expression in primary focal segmental glomerulosclerosis: A NEPTUNE study by Maksimowski, Nicholas A, Scholey, James W, Williams, Vanessa R

“…Background Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of experimental kidney disease. ACE2 is on the X chromosome, and in…”
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Angiotensin-[1–7] attenuates kidney injury in experimental Alport syndrome by Choi, Hong Sang, Kim, In Jin, Kim, Chang Seong, Ma, Seong Kwon, Scholey, James W., Kim, Soo Wan, Bae, Eun Hui

“…Angiotensin-[1–7] (Ang-[1–7]) antagonize the actions of the renin-angiotensin-system via the Mas receptor and thereby exert renoprotective effects. Murine…”
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Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy by OUDIT, Gavin Y, LIU, George C, HERZENBERG, Andrew M, KASSIRI, Zamaneh, SCHOLEY, James W, JIUCHANG ZHONG, BASU, Ratnadeep, CHOW, Fung L, ZHOU, Joyce, LOIBNER, Hans, JANZEK, Evelyne, SCHUSTER, Manfred, PENNINGER, Josef M

“…Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy Gavin Y. Oudit 1 , 2 , George C. Liu 3 , JiuChang Zhong 1 , 2 , Ratnadeep Basu 1 , 2 ,…”
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Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways by Fang, Fei, Liu, George C, Kim, Crystal, Yassa, Rana, Zhou, Joyce, Scholey, James W

“…Obesity is a risk factor for chronic kidney disease (CKD) progression. Circulating levels of adiponectin, an adipokine, decrease with obesity and play a…”
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Follistatin-Like-1 (FSTL1) Is a Fibroblast-Derived Growth Factor That Contributes to Progression of Chronic Kidney Disease by Maksimowski, Nicholas A, Song, Xuewen, Bae, Eun Hui, Reich, Heather, John, Rohan, Pei, York, Scholey, James W, Nephrotic Syndrome Study Network Neptune

“…Our understanding of the mechanisms responsible for the progression of chronic kidney disease (CKD) is incomplete. Microarray analysis of kidneys at 4 and 7…”
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Inhibition of BRD4 Reduces Neutrophil Activation and Adhesion to the Vascular Endothelium Following Ischemia Reperfusion Injury by Reid, Shelby, Fine, Noah, Bhosle, Vikrant K, Zhou, Joyce, John, Rohan, Glogauer, Michael, Robinson, Lisa A, Scholey, James W

“…Renal ischemia reperfusion injury (IRI) is associated with inflammation, including neutrophil infiltration that exacerbates the initial ischemic insult. The…”
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Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction by Kassiri, Zamaneh, Zhong, Jiuchang, Guo, Danny, Basu, Ratnadeep, Wang, Xiuhua, Liu, Peter P, Scholey, James W, Penninger, Josef M, Oudit, Gavin Y

“…Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that metabolizes Ang II into Ang 1-7, thereby functioning as a negative regulator of the…”
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Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ by Suh, Sang Heon, Choi, Hong Sang, Kim, Chang Seong, Kim, In Jin, Ma, Seong Kwon, Scholey, James W, Kim, Soo Wan, Bae, Eun Hui

“…Despite the wide use of angiotensin II receptor blockers in the treatment of Alport syndrome (AS), the mechanism as to how angiotensin II receptor blockers…”
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Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes by Van, Julie A D, Clotet-Freixas, Sergi, Hauschild, Anne-Christin, Batruch, Ihor, Jurisica, Igor, Elia, Yesmino, Mahmud, Farid H, Sochett, Etienne, Diamandis, Eleftherios P, Scholey, James W, Konvalinka, Ana

“…Diabetes is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete…”
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Angiotensin-(1-7)-induced activation of ERK1/2 is cAMP/protein kinase A-dependent in glomerular mesangial cells by Liu, George C, Oudit, Gavin Y, Fang, Fei, Zhou, Joyce, Scholey, James W

“…The renin-angiotensin system (RAS) plays an important role in renal physiology and kidney injury. Although the cellular effects of the RAS activation are…”
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The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy by Hodgin, Jeffrey B, Berthier, Celine C, John, Rohan, Grone, Elisabeth, Porubsky, Stefan, Gröne, Hermann-Josef, Herzenberg, Andrew M, Scholey, James W, Hladunewich, Michelle, Cattran, Daniel C, Kretzler, Matthias, Reich, Heather N

“…IgA nephropathy (IgAN) is a clinically and pathologically heterogeneous disease. Endocapillary proliferation is associated with higher risk of progressive…”
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A molecular signature of proteinuria in glomerulonephritis by Reich, Heather N, Tritchler, David, Cattran, Daniel C, Herzenberg, Andrew M, Eichinger, Felix, Boucherot, Anissa, Henger, Anna, Berthier, Celine C, Nair, Viji, Cohen, Clemens D, Scholey, James W, Kretzler, Matthias

“…Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an…”
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Characterization of the Intrarenal Renin-Angiotensin System in Experimental Alport Syndrome by Bae, Eun Hui, Konvalinka, Ana, Fang, Fei, Zhou, Xiaohua, Williams, Vanessa, Maksimowski, Nicholas, Song, Xuewen, Zhang, Shao-Ling, John, Rohan, Oudit, Gavin Y, Pei, York, Scholey, James W

“…Blockade of the renin-angiotensin system attenuates the progression of experimental and clinical Alport syndrome (AS); however, the underlying mechanism(s)…”
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Evaluation of Clinical Outcomes and Renal Vascular Pathology among Patients with Lupus by Barber, Claire, Herzenberg, Andrew, Aghdassi, Ellie, Su, Jiandong, Lou, Wendy, Qian, Gan, Yip, Jonathan, Nasr, Samih H, Thomas, David, Scholey, James W, Wither, Joan, Urowitz, Murray, Gladman, Dafna, Reich, Heather, Fortin, Paul R

“…The objective of this study was to determine the clinical significance of renal vascular lesions in lupus nephritis. Renal vascular lesions defined as…”
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Recent Approaches to Targeting Canonical NF κ B Signaling in the Early Inflammatory Response to Renal IRI by Reid, Shelby, Scholey, James W

“…Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with…”
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