Search Results - "Scholey, J. W."

The effect of renal hyperfiltration on urinary inflammatory cytokines/chemokines in patients with uncomplicated type 1 diabetes mellitus by Har, R., Scholey, J. W., Daneman, D., Mahmud, F. H., Dekker, R., Lai, V., Elia, Y., Fritzler, M. L., Sochett, E. B., Reich, H. N., Cherney, D. Z. I.

“…Aims/hypothesis High intraglomerular pressure causes renal inflammation in experimental models of diabetes. Our objective was to determine whether renal…”
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Exploring the Motivational Drivers of Young Adults with Diabetes for Participation in Kidney Research by Mohini, P, Palaganas, M, Elia, Y, Motran, L, Sochett, E, Curtis, J, Scholey, JW, McArthur, L, Mahmud, FH

“…Understanding motivational drivers and barriers to patient participation in diabetes research are important to ensure research is relevant and valuable. Young…”
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Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria by Cherney, D. Z. I., Scholey, J. W., Daneman, D., Dunger, D. B., Dalton, R. N., Moineddin, R., Mahmud, F. H., Dekker, R., Elia, Y., Sochett, E., Reich, H. N.

“…Diabet. Med. 29, 1297–1302 (2012) Aims  Patients with the highest albumin:creatinine ratio within the normal range are at an increased risk for developing…”
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Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase by Shastry, S., Ingram, A.J., Scholey, J.W., James, L.R.

“…Hyperhomocysteinemia is prevalent among patients with chronic kidney disease (CKD) and has been linked to progressive kidney and vascular diseases. Increased…”
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Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse by Liu, G. C., Fang, F., Zhou, J., Koulajian, K., Yang, S., Lam, L., Reich, H. N., John, R., Herzenberg, A. M., Giacca, A., Oudit, G. Y., Scholey, J. W.

“…Aims/hypothesis Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell…”
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NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents by KOULAJIAN, K, DESAI, T, LIU, G. C, IVOVIC, A, PATTERSON, J. N, TANG, C, EL-BENNA, J, JOSEPH, J. W, SCHOLEY, J. W, GIACCA, A

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The effect of oral contraceptives on the nitric oxide system and renal function by Cherney, D Z I, Scholey, J W, Cattran, D C, Kang, A K, Zimpelmann, J, Kennedy, C, Lai, V, Burns, K D, Miller, J A

“…We have demonstrated that oral contraceptive (OC) users exhibit elevated angiotensin II levels and angiotensin II type 1 receptor expression, indicative of…”
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Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II by MILLER, J. A, THAI, K, SCHOLEY, J. W

“…Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II. Most of the known actions of angiotensin II (Ang II) are…”
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Effect of oral contraceptives on the renin angiotensin system and renal function by Kang, A K, Duncan, J A, Cattran, D C, Floras, J S, Lai, V, Scholey, J W, Miller, J A

“…We examined the effect of oral contraceptive (OC) usage on the renin angiotensin system (RAS) in two related experiments. In the first experiment, subjects…”
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Angiotensin II type 1 receptor gene polymorphism and the response to hyperglycemia in early type 1 diabetes by MILLER, J. A, THAI, K, SCHOLEY, J. W

“…Angiotensin II type 1 receptor gene polymorphism and the response to hyperglycemia in early type 1 diabetes. J A Miller , K Thai and J W Scholey Department of…”
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Plasma uric acid effects on glomerular haemodynamic profile of patients with uncomplicated Type 1 diabetes mellitus by Lytvyn, Y., Škrtić, M., Yang, G. K., Lai, V., Scholey, J. W., Yip, P. M., Perkins, B. A., Cherney, D. Z. I.

“…Aims Increased plasma uric acid (PUA) levels are associated with impaired renal function in patients with Type 1 diabetes, but the mechanisms are not well…”
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The impact of sex in primary glomerulonephritis by Cattran, Daniel C., Reich, Heather N., Beanlands, Heather J., Miller, Judith A., Scholey, James W., Troyanov, Stéphan

“…Background. Studies comparing the impact of sex in primary glomerular disease have reported conflicting results. Methods. We analysed 395 membranous (MGN), 370…”
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Deletion of p47 phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse by Liu, G. C., Fang, F., Zhou, J., Koulajian, K., Yang, S., Lam, L., Reich, H. N., John, R., Herzenberg, A. M., Giacca, A., Oudit, G. Y., Scholey, J. W.

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NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents by Koulajian, K., Desai, T., Liu, G. C., Ivovic, A., Patterson, J. N., Tang, C., El-Benna, J., Joseph, J. W., Scholey, J. W., Giacca, A.

“…Aims/hypothesis The activation of NADPH oxidase has been implicated in NEFA-induced beta cell dysfunction. However, the causal role of this activation in vivo…”
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Activation of mesangial cell signaling cascades in response to mechanical strain by Ingram, Alistair J., Ly, Hao, Thai, Kerri, Kang, Myung, Scholey, James W.

“…Activation of mesangial cell signaling cascades in response to mechanical strain. Mesangial cells (MCs) are constantly exposed to pulsatile stretch and…”
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Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells by Ingram, A J, James, L, Thai, K, Ly, H, Cai, L, Scholey, J W

“…Mesangial cells (MC), grown on extracellular matrix (ECM) protein-coated plates and stretched, proliferate and produce ECM, recapitulating in vivo responses to…”
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Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli by Kang, Myoung Jae, Wu, Xiaoyan, Ly, Hao, Thai, Kerri, Scholey, James W.

“…Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli. We have reported that hyperglycemia increases c-jun…”
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Stretch-induced mesangial cell ERK1/ERK2 activation is enhanced in high glucose by decreased dephosphorylation by Dlugosz, J A, Munk, S, Kapor-Drezgic, J, Goldberg, H J, Fantus, I G, Scholey, J W, Whiteside, C I

“…Glomerular hypertension and hyperglycemia are major determinants of diabetic nephropathy. We sought to identify the mechanisms whereby stretch-induced…”
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Mesangial cell signaling cascades in response to mechanical strain and glucose by Ingram, Alistair John, Ly, Hao, Thai, Kerri, Kang, Myung-Jae, Scholey, James W.

“…Mesangial cell signaling cascades in response to mechanical strain and glucose. Elevated glucose levels and glomerular hypertension (Pgc) are considered to…”
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Effects of diabetes and hypertension on glomerular transforming growth factor-β receptor expression by Kang, Myoung J., Ingram, Alistair, Ly, Hao, Thai, Kerri, Scholey, James W.

“…Effects of diabetes and hypertension on glomerular transforming growth factor-β receptor expression. Several studies have suggested that transforming growth…”
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