Search Results - "Scholes, Natalie S."

Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation by Kagiou, Chrysanthi, Cisneros, Jose A., Farnung, Jakob, Liwocha, Joanna, Offensperger, Fabian, Dong, Kevin, Yang, Ka, Tin, Gary, Horstmann, Christina S., Hinterndorfer, Matthias, Paulo, Joao A., Scholes, Natalie S., Sanchez Avila, Juan, Fellner, Michaela, Andersch, Florian, Hannich, J. Thomas, Zuber, Johannes, Kubicek, Stefan, Gygi, Steven P., Schulman, Brenda A., Winter, Georg E.

“…Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the…”
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Molecular Dynamics of "Fuzzy" Transcriptional Activator-Coactivator Interactions by Scholes, Natalie S, Weinzierl, Robert O J

“…Transcriptional activation domains (ADs) are generally thought to be intrinsically unstructured, but capable of adopting limited secondary structure upon…”
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Identification and selectivity profiling of small-molecule degraders via multi-omics approaches by Scholes, Natalie S, Mayor-Ruiz, Cristina, Winter, Georg E

“…The therapeutic modality of targeted protein degradation promises to overcome limitations of traditional pharmacology. Small-molecule degraders recruit…”
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A three-step framework for programming pattern formation by Scholes, Natalie S., Isalan, Mark

“…•Synthetic engineering of pattern formation is an essential step towards regenerative medicine.•A three-step framework commonly underpins engineering…”
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Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling by Ng, Amanda, Offensperger, Fabian, Cisneros, Jose A., Scholes, Natalie S., Malik, Monika, Villanti, Ludovica, Rukavina, Andrea, Ferrada, Evandro, Hannich, J. Thomas, Koren, Anna, Kubicek, Stefan, Superti-Furga, Giulio, Winter, Georg E.

“…Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiquitin–proteasome system. While MGDs were historically…”
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