Search Results - "Scholer‐Dahirel, Alix"

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers by Givel, Anne-Marie, Kieffer, Yann, Scholer-Dahirel, Alix, Sirven, Philemon, Cardon, Melissa, Pelon, Floriane, Magagna, Ilaria, Gentric, Géraldine, Costa, Ana, Bonneau, Claire, Mieulet, Virginie, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima

“…High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene…”
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Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific by Michea, Paula, Noël, Floriane, Zakine, Eve, Czerwinska, Urszula, Sirven, Philémon, Abouzid, Omar, Goudot, Christel, Scholer-Dahirel, Alix, Vincent-Salomon, Anne, Reyal, Fabien, Amigorena, Sebastian, Guillot-Delost, Maude, Segura, Elodie, Soumelis, Vassili

“…The functions and transcriptional profiles of dendritic cells (DCs) result from the interplay between ontogeny and tissue imprinting. How tumors shape human…”
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Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm by Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., Graaf, Piet H., Kierzek, Andrzej M.

“…Drug development in oncology commonly exploits the tools of molecular biology to gain therapeutic benefit through reprograming of cellular responses. In…”
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Definition of a novel breast tumor-specific classifier based on secretome analysis by Sirven, Philémon, Faucheux, Lilith, Grandclaudon, Maximilien, Michea, Paula, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima, Scholer-Dahirel, Alix, Guillot-Delost, Maude, Soumelis, Vassili

“…During cancer development, the normal tissue microenvironment is shaped by tumorigenic events. Inflammatory mediators and immune cells play a key role during…”
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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling by Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E

“…Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically…”
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Determinants of Wnt/β-catenin pathway dependency in colorectal cancer by Scholer-Dahirel, Alix, McLaughlin, Margaret E.

“…Comment on: Scholer-Dahirel A, et al. Proc Natl Acad Sci USA 2011; 108:17135-40…”
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The role of reactive oxygen species and metabolism on cancer cells and their microenvironment by Costa, Ana, Scholer-Dahirel, Alix, Mechta-Grigoriou, Fatima

“…Abstract Compelling evidence show that reactive oxygen species (ROS) levels are finely regulated in the cell and can act as “second messengers” in response to…”
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Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer by Costa, Ana, Kieffer, Yann, Scholer-Dahirel, Alix, Pelon, Floriane, Bourachot, Brigitte, Cardon, Melissa, Sirven, Philemon, Magagna, Ilaria, Fuhrmann, Laetitia, Bernard, Charles, Bonneau, Claire, Kondratova, Maria, Kuperstein, Inna, Zinovyev, Andrei, Givel, Anne-Marie, Parrini, Maria-Carla, Soumelis, Vassili, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima

“…Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment. Here, we characterize four CAF subsets in breast cancer with distinct…”
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The PD-L1/4-1BB Bispecific Antibody-Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner by Peper-Gabriel, Janet K, Pavlidou, Marina, Pattarini, Lucia, Morales-Kastresana, Aizea, Jaquin, Thomas J, Gallou, Catherine, Hansbauer, Eva-Maria, Richter, Marleen, Lelievre, Helene, Scholer-Dahirel, Alix, Bossenmaier, Birgit, Sancerne, Celine, Riviere, Matthieu, Grandclaudon, Maximilien, Zettl, Markus, Bel Aiba, Rachida S, Rothe, Christine, Blanc, Veronique, Olwill, Shane A

“…While patients responding to checkpoint blockade often achieve remarkable clinical responses, there is still significant unmet need due to resistant or…”
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Foxp3 + T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes by Boissonnas, Alexandre, Scholer-Dahirel, Alix, Simon-Blancal, Virginie, Pace, Luigia, Valet, Fabien, Kissenpfennig, Adrien, Sparwasser, Tim, Malissen, Bernard, Fetler, Luc, Amigorena, Sebastian

“…Regulatory T (Treg) cells limit the onset of effective antitumor immunity, through yet-ill-defined mechanisms. We showed the rejection of established ovalbumin…”
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Abstract LB135: Simultaneous costimulatory T-cell engagement and checkpoint inhibition by PRS-344/S095012, a PD-L1/4-1BB bispecific compound for tumor localized activation of the immune system by Morales-Kastresana, Aizea, Pavlidou, Marina, Peper, Janet, Pattarini, Lucia, Barthels, Christian, Hansbauer, Eva-Maria, Aiba, Rachida Bel, Bossenmaier, Birgit, Scholer-Dahirel, Alix, Jaquin, Thomas, Gallou, Catherine, Blanc, Véronique, Rothe, Christine, Olwill, Shane

“…Background. Preclinical and clinical data suggest that 4-1BB (CD137), a costimulatory immunoreceptor mainly expressed by cytotoxic cells, represents a…”
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Control of cancer-associated fibroblast function by oxidative stress: A new piece in the puzzle by Scholer-Dahirel, Alix, Costa, Ana, Mechta-Grigoriou, Fatima

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Abstract LB220: The anticalin-antibody bispecific PRS-352/S095025 strongly stimulates human CD4+ T cells in a PD-L1-dependent manner by Pattarini, Lucia, Pavlidou, Marina, Morales, Aizea Kastresana, Peper-Gabriel, Janet, Riviere, Matthieu, Demarles, Didier, Scholer-Dahirel, Alix, Blanc, Veronique, Olwill, Shane

“…Background: OX40, a member of the tumor necrosis factor receptor superfamily, is a costimulatory molecule promoting survival and cytokine release by effector T…”
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No evidence for TSLP pathway activity in human breast cancer by Ghirelli, Cristina, Sadacca, Benjamin, Reyal, Fabien, Zollinger, Raphaël, Michea, Paula, Sirven, Philémon, Pattarini, Lucia, Martínez-Cingolani, Carolina, Guillot-Delost, Maude, Nicolas, André, Scholer-Dahirel, Alix, Soumelis, Vassili

“…Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that primes dendritic cells for Th2 induction. It has been implicated in different…”
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Abstract CT255: Study of PRS-344/S095012 a PD-L1/4-1BB bispecific antibody-Anticalin®-fusion in patients with solid tumors by Jungels, Christiane, Kotecki, Nuria, Calvo, Emiliano, Garralda, Elena, Price, Timothy, Zahn, Xiaojiang, Abbas, Atif, Mahnke, Lisa, Rauschning, Winrich, Morales-Kastresana, Aizea, Pattarini, Lucia, Bossenmaier, Birgit, Scholer-Dahirel, Alix, Demuth, Tim, Legrande, Julie

“…PRS-344/S095012 is a bispecific antibody-Anticalin® fusion protein targeting PD-L1 and 4-1BB. It is designed to block the PD-1/PD-L1 axis and localize 4-1BB…”
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The PD-L1/4-1BB bispecific Antibody-Anticalin fusion protein PRS-344/S095012 elicits strong T-cell stimulation in a tumor-localized manner by Peper-Gabriel, Janet K, Pavlidou, Marina, Pattarini, Lucia, Morales-Kastresana, Aizea, Jaquin, Thomas J, Gallou, Catherine, Hansbauer, Eva-Maria, Richter, Marleen, Lelievre, Helene, Scholer-Dahirel, Alix, Bossenmaier, Birgit, Sancerne, Celine, Riviere, Matthieu, Grandclaudon, Maximilien, Zettl, Markus, Bel Aiba, Rachida Siham, Rothe, Christine, Blanc, Veronique, Olwill, Shane A

“…While patients responding to checkpoint blockade often achieve remarkable clinical responses, there is still significant unmet need due to resistant or…”
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Ligand-receptor dissociated expression explains high TSLP without prognostic impact in human primary head and neck squamous cell carcinoma by Guillot-Delost, Maude, Guilleré, Lia, Berger, Frédérique, Ventre, Aurore, Michea, Paula, Sirven, Philémon, Pattarini, Lucia, Scholer-Dahirel, Alix, Kebir, Fatima-Zahra, Huerre, Michel, Chouchane-Mlik, Olfa, Lappartient, Emmanuelle, Rodriguez, José, Jouffroy, Thomas, Klijanienko, Jerzy, Nicolas, André, Sastre-Garau, Xavier, Honorio, Sofia, Mosseri, Véronique, Le Peltier, Nelly, Sablin, Marie-Paule, Le Tourneau, Christophe, Tartour, Éric, Badoual, Cécile, Soumelis, Vassili

“…Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine expressed by epithelial cells during allergic inflammation, and activating dendritic…”
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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/[Beta]-catenin signaling by Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E

“…Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically…”
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