Search Results - "Scholefield, John H"

Quality of Life and Medico-Legal Implications Following Iatrogenic Bile Duct Injuries by Hariharan, Deepak, Psaltis, Emmanouil, Scholefield, John H., Lobo, Dileep N.

“…In this review we aimed to evaluate quality of life after bile duct injury and the consequent medico-legal implications. A comprehensive English…”
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Overexpression of FLIPL Is an Independent Marker of Poor Prognosis in Colorectal Cancer Patients by ULLENHAG, Gustave J, MUKHERJEE, Abhik, WATSON, Nicholas F. S, AL-ATTAR, Ahmad H, SCHOLEFIELD, John H, DURRANT, Lindy G

“…Purpose: Colorectal cancer is one of the most common cancers. The tumor necrosis factor–related apoptosis inducing ligand (TRAIL) pathway transmits apoptotic…”
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Expression of the stress‐related MHC class I chain‐related protein MICA is an indicator of good prognosis in colorectal cancer patients by Watson, Nicholas F.S., Spendlove, Ian, Madjd, Zahra, McGilvray, Roger, Green, Andrew R., Ellis, Ian O., Scholefield, John H., Durrant, Lindy G.

“…The realization of targeted cancer therapy has driven the need to improve selection of patients with colorectal cancer for adjuvant therapy, leading to a…”
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The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer by Duncan, Timothy J, Watson, Nicholas F S, Al-Attar, Ahmad H, Scholefield, John H, Durrant, Lindy G

“…MUC1 and MUC3 are from a large family of glycoproteins with an aberrant expression profile in various malignancies. Much interest has been focused on the role…”
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A randomized trial of oral vs. topical diltiazem for chronic anal fissures by Jonas, M, Neal, K R, Abercrombie, J F, Scholefield, J H

“…Chemical sphincterotomy has proved effective in treating chronic anal fissure. Glyceryl trinitrate is the most widely used agent, and topical 0.2 percent…”
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Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) by Cairns, Stuart R, Scholefield, John H, Steele, Robert J, Dunlop, Malcolm G, Thomas, Huw J W, Evans, Gareth D, Eaden, Jayne A, Rutter, Matthew D, Atkin, Wendy P, Saunders, Brian P, Lucassen, Anneke, Jenkins, Paul, Fairclough, Peter D, Woodhouse, Christopher R J

“…The British Society of Gastroenterology (BSG) and the Association of Coloproctology for Great Britain and Ireland (ACPGBI) commissioned this update of the 2002…”
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A Neoadjuvant/Adjuvant Randomized Trial of Colorectal Cancer Patients Vaccinated with an Anti-Idiotypic Antibody, 105AD7, Mimicking CD55 by Ullenhag, Gustav J, Spendlove, Ian, Watson, Nicholas F S, Indar, Adrian A, Dube, Mukul, Robins, Richard A, Maxwell-Armstrong, Charles, Scholefield, John H, Durrant, Lindy G

“…Purpose: To assess the tolerability and effectiveness of 105AD7 vaccination in colorectal cancer patients. 105AD7 is a human anti-idiotypic antibody mimicking…”
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Nuclear expression of phosphorylated focal adhesion kinase is associated with poor prognosis in human colorectal cancer by Albasri, Abdulkader, Fadhil, Wakkas, Scholefield, John H, Durrant, Lindy G, Ilyas, Mohammad

“…To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association…”
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Results of laparoscopic colorectal surgery from a national training center by Maitra, Rudra Krishna, Acheson, Austin G, Gornall, Chris, Scholefield, John H, Williams, Julian P, Maxwell-Armstrong, Charles A

“…Summary Background/purpose Trials have shown laparoscopic colorectal surgery to be safe. We aim to analyze the long-term results from a single national…”
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Management of haemorrhoids by Acheson, Austin G, Scholefield, John H

“…Tips for non-specialists Haemorrhoids are common in all age groups Most patients can be treated in primary care with dietary advice and avoidance of straining…”
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Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer by Simpson, Jonathan A D, Al-Attar, Ahmad, Watson, Nicholas F S, Scholefield, John H, Ilyas, Mohammad, Durrant, Lindy G

“…To evaluate immunosurveillance/editing in colorectal cancer. Transformation stimulates the production of interferon gamma (IFNgamma) which signals via the…”
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Endothelin‐1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention by Lohsiriwat, Varut, Scholefield, John H, Wilson, Vincent G, Dashwood, Michael R

“…Background and Purpose Haemorrhoids is a common anorectal condition affecting millions worldwide. We have studied the effect of endothelin‐1 (ET‐1) and the…”
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Stapled hemorrhoidopexy compared with conventional hemorrhoidectomy: Systematic review of randomized, controlled trials by NISAR, Pasha J, ACHESON, Austin G, NEAL, Keith R, SCHOLEFIELD, John H

“…This study was designed to determine whether conventional hemorrhoidectomy or stapled hemorrhoidopexy is superior for the management of hemorrhoids. A…”
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Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis by Watson, Nicholas F.S., Ramage, Judith M., Madjd, Zahra, Spendlove, Ian, Ellis, Ian O., Scholefield, John H., Durrant, Lindy G.

“…Many colorectal tumors lose or downregulate cell surface expression of MHC class I molecules conferring resistance to T‐cell‐mediated attack. It has been…”
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Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients by Watson, Nicholas F S, Madjd, Zahra, Scrimegour, Duncan, Spendlove, Ian, Ellis, Ian O, Scholefield, John H, Durrant, Lindy G

“…Advances in our understanding of the molecular biology of colorectal cancer have fuelled the search for novel molecular prognostic markers to complement…”
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Faecal incontinence: the 'Cinderella' disorder by Scholefield, John H., Walker, David

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Managing haemorrhoids by Nisar, Pasha J, Scholefield, John H

“…Internal haemorrhoids originate from the internal haemorrhoidal venous plexus above the dentate line; external haemorrhoids originate from the external plexus…”
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Pharmacological characteristics of endothelin receptors on sheep rectal blood vessels by Lohsiriwat, Varut, Scholefield, John H., Dashwood, Michael R., Wilson, Vincent G.

“…Haemorrhoids is associated with high blood flow of the anorectal region. The question of whether pharmacological manipulation of vascular supply can relieve…”
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A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure by Lund, J N, Scholefield, J H

“…Anal fissure is most commonly treated surgically by internal anal sphincterotomy. However, there is some concern over the effects of this procedure on…”
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Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study by Jonas, Marion, Speake, William, Scholefield, John H

“…Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal…”
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