Search Results - "Scholefield, J. H."

Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up by Scholefield, J H, Moss, S M, Mangham, C M, Whynes, D K, Hardcastle, J D

“…Three large randomised trials have shown that screening for colorectal cancer (CRC) using the faecal occult blood test (FOBt) can reduce the mortality from…”
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Malignant transformation of high-grade anal intraepithelial neoplasia by Scholefield, J. H., Castle, M. T., Watson, N. F. S.

“…Background: The natural history of anal intraepithelial neoplasia (AIN) is uncertain. This makes management problematic as treatment options to eradicate the…”
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Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms by Simpson, J., Sundler, F., Humes, D. J., Jenkins, D., Scholefield, J. H., Spiller, R. C.

“…:  Some patients with colonic diverticula suffer recurrent abdominal pain and exhibit visceral hypersensitivity, though the mechanism is unclear. Prior…”
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Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation by Humes, D. J., Simpson, J., Smith, J., Sutton, P., Zaitoun, A., Bush, D., Bennett, A., Scholefield, J. H., Spiller, R. C.

“…Background  Recurrent abdominal pain is reported by a third of patients with diverticulosis, particularly those with previous episodes of acute diverticulitis…”
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Facilitating surgical research across Europe by Scholefield, J. H., Lobo, D. N.

“…Frameworks are in place to facilitate surgical trials…”
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Pathogenesis of colonic diverticula by Simpson, J., Scholefield, J. H., Spiller, R. C.

“…Background: Diverticula are herniations through the colonic wall and are therefore likely to be due to a weakness within the wall, an alteration in…”
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Psychological and colonic factors in painful diverticulosis by Humes, D. J., Simpson, J., Neal, K. R., Scholefield, J. H., Spiller, R. C.

“…Background: The importance of psychological factors in symptom expression in diverticulosis is unknown. This follow‐up study assessed the relative importance…”
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Aetiology and treatment of anal fissure by Lund, J. N., Scholefield, J. H.

“…Anal fissure is a common problem that causes significant morbidity in a young and otherwise healthy population. Treatment has remained largely unchanged for…”
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CD24 shows early upregulation and nuclear expression but is not a prognostic marker in colorectal cancer by Ahmed, M A H, Al-Attar, A, Kim, J, Watson, N F S, Scholefield, J H, Durrant, L G, Ilyas, M

“…The putative stem cell marker CD24 is a small, heavily glycosylated, cell surface molecule which was originally associated with tumour metastasis. Recently it…”
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Origin of symptoms in diverticular disease by Simpson, J., Scholefield, J. H., Spiller, R. C.

“…Background: A significant number of patients with colonic diverticula experience unexplained, recurrent, short‐lived but often debilitating abdominal pain and…”
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Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial by Scholefield, J H, Moss, S, Sufi, F, Mangham, C M, Hardcastle, J D

“…Background: Three large randomised trials have shown that screening for colorectal cancer using faecal occult blood (FOB) tests can reduce the mortality from…”
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A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures by Scholefield, J H, Bock, J U, Marla, B, Richter, H J, Athanasiadis, S, Pröls, M, Herold, A

“…Background: Anal fissure is a common painful condition affecting the anal canal. The majority of acute fissures heal spontaneously. However, some of these…”
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Guidelines for colorectal cancer screening in high risk groups by Cairns, S, Scholefield, J H

“…The British Society of Gastroenterology (BSG) and the Association of Coloproctolgy for Great Britain and Ireland (ACPGBI) commissioned these guidelines. The…”
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Population screening for colorectal cancer: the implications of an ageing population by Macafee, D A L, Waller, M, Whynes, D K, Moss, S, Scholefield, J H

“…Population screening for colorectal cancer (CRC) has recently commenced in the United Kingdom supported by the evidence of a number of randomised trials and…”
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Analysis of deaths occurring within the Nottingham trial of faecal occult blood screening for colorectal cancer by Whynes, D K, Mangham, C M, Balfour, T W, Scholefield, J H

“…To report the causes of, and ages at, death of subjects in an English colorectal cancer screening trial. Analysis of 78 708 deaths occurring between 1981 and…”
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Investigation of the distribution and function of α‐adrenoceptors in the sheep isolated internal anal sphincter by Rayment, SJ, Eames, T, Simpson, JAD, Dashwood, MR, Henry, Y, Gruss, H, Acheson, AG, Scholefield, JH, Wilson, VG

“…BACKGROUND AND PURPOSE We have investigated the distribution of α‐adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and…”
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A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure by Lund, J N, Scholefield, J H

“…Anal fissure is most commonly treated surgically by internal anal sphincterotomy. However, there is some concern over the effects of this procedure on…”
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Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis by Simpson, J., Sundler, F., Humes, D. J., Jenkins, D., Wakelin, D., Scholefield, J. H., Spiller, R. C.

“…Diverticulitis causes recurrent abdominal pain associated with increased mucosal expression of mucosal galanin and substance P (SP). We studied changes in…”
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Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) by Cairns, Stuart R, Scholefield, John H, Steele, Robert J, Dunlop, Malcolm G, Thomas, Huw J W, Evans, Gareth D, Eaden, Jayne A, Rutter, Matthew D, Atkin, Wendy P, Saunders, Brian P, Lucassen, Anneke, Jenkins, Paul, Fairclough, Peter D, Woodhouse, Christopher R J

“…The British Society of Gastroenterology (BSG) and the Association of Coloproctology for Great Britain and Ireland (ACPGBI) commissioned this update of the 2002…”
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Faecal calprotectin levels in a high risk population for colorectal neoplasia by Kronborg, O, Ugstad, M, Fuglerud, P, Johne, B, Hardcastle, J, Scholefield, J H, Vellacott, K, Moshakis, V, Reynolds, J R

“…BACKGROUND Faecal concentrations of the protein calprotectin have been found to be elevated in patients with colorectal neoplasia, suggesting that it might be…”
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