Search Results - "Schol, Jordy"

Cell therapy for intervertebral disc repair: Clinical perspective by Sakai, Daisuke, Schol, Jordy

“…Low back pain is the main cause of disability and is associated with intervertebral disc degeneration. Contemporary treatments are limited to palliative…”
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Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease by Sakai, Daisuke, Schol, Jordy, Watanabe, Masahiko

“…Low back pain is critical health, social, and economic issue in modern societies. This disease is often associated with intervertebral disc degeneration;…”
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Comprehensive narrative review on the analysis of outcomes from cell transplantation clinical trials for discogenic low back pain by Schol, Jordy, Sakai, Daisuke

“…Intervertebral disc (IVD) degeneration is one of the primary causes of low back pain (LBP) and despite a prominent prevalence, present treatment options remain…”
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Enzymatic chemonucleolysis for lumbar disc herniation—an assessment of historical and contemporary efficacy and safety: a systematic review and meta-analysis by Schol, Jordy, Ambrosio, Luca, Tamagawa, Shota, Joyce, Kieran, Ruiz-Fernández, Clara, Nomura, Akira, Sakai, Daisuke

“…Lumbar disc herniation (LDH) is often managed surgically. Enzymatic chemonucleolysis emerged as a non-surgical alternative. This systematic review and…”
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Recombinant Laminin-511 Fragment (iMatrix-511) Coating Supports Maintenance of Human Nucleus Pulposus Progenitor Cells In Vitro by Soma, Hazuki, Sakai, Daisuke, Nakamura, Yoshihiko, Tamagawa, Shota, Warita, Takayuki, Schol, Jordy, Matsushita, Erika, Naiki, Mitsuru, Sato, Masato, Watanabe, Masahiko

“…The angiopoietin-1 receptor (Tie2) marks specific nucleus pulposus (NP) progenitor cells, shows a rapid decline during aging and intervertebral disc…”
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Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells by Sako, Kosuke, Sakai, Daisuke, Nakamura, Yoshihiko, Schol, Jordy, Matsushita, Erika, Warita, Takayuki, Horikita, Natsumi, Sato, Masato, Watanabe, Masahiko

“…Previous work showed a link between Tie2 nucleus pulposus progenitor cells (NPPC) and disc degeneration. However, NPPC remain difficult to maintain in culture…”
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Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells by Munesada, Daiki, Sakai, Daisuke, Nakamura, Yoshihiko, Schol, Jordy, Matsushita, Erika, Tamagawa, Shota, Sako, Kosuke, Ogasawara, Shota, Sato, Masato, Watanabe, Masahiko

“…To develop an off-the-shelf therapeutic product for intervertebral disc (IVD) repair using nucleus pulposus cells (NPCs), it is beneficial to mitigate dimethyl…”
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Revisiting the Newest Vital Sign Survey: Addressing Concerns About This Health Literacy Assessment Tool by Schol, Jordy, Ambrosio, Luca, Yamada, Yoshiyuki, Sakai, Daisuke

“…National health agencies, such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority, require specific identification on food…”
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Assessment of Tie2-Rejuvenated Nucleus Pulposus Cell Transplants from Young and Old Patient Sources Demonstrates That Age Still Matters by Otani, Yuto, Schol, Jordy, Sakai, Daisuke, Nakamura, Yoshihiko, Sako, Kosuke, Warita, Takayuki, Tamagawa, Shota, Ambrosio, Luca, Munesada, Daiki, Ogasawara, Shota, Matsushita, Erika, Kawachi, Asami, Naiki, Mitsuru, Sato, Masato, Watanabe, Masahiko

“…Cell transplantation is being actively explored as a regenerative therapy for discogenic back pain. This study explored the regenerative potential of Tie2…”
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SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential by Tamagawa, Shota, Sakai, Daisuke, Nojiri, Hidetoshi, Nakamura, Yoshihiko, Warita, Takayuki, Matsushita, Erika, Schol, Jordy, Soma, Hazuki, Ogasawara, Shota, Munesada, Daiki, Koike, Masato, Shimizu, Takahiko, Sato, Masato, Ishijima, Muneaki, Watanabe, Masahiko

“…Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress has been…”
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Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section by Lai, Alon, Gansau, Jennifer, Gullbrand, Sarah E., Crowley, James, Cunha, Carla, Dudli, Stefan, Engiles, Julie B., Fusellier, Marion, Goncalves, Raquel M., Nakashima, Daisuke, Okewunmi, Jeffrey, Pelletier, Matthew, Presciutti, Steven M., Schol, Jordy, Takeoka, Yoshiki, Yang, Sidong, Yurube, Takashi, Zhang, Yejia, Iatridis, James C.

“…Background Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD) degeneration and regeneration. IVD morphology is commonly…”
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A comprehensive review of cell transplantation and platelet‐rich plasma therapy for the treatment of disc degeneration‐related back and neck pain: A systematic evidence‐based analysis by Schol, Jordy, Tamagawa, Shota, Volleman, Tibo Nico Emmie, Ishijima, Muneaki, Sakai, Daisuke

“…Low back pain (LBP) and neck pain predominate as the primary causes of disability. Cell‐ and platelet‐rich plasma (PRP) products are potential therapies with…”
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Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro by Nukaga, Tadashi, Sakai, Daisuke, Schol, Jordy, Suyama, Kaori, Nakai, Tomoko, Hiyama, Akihiko, Watanabe, Masahiko

“…Introduction: Intervertebral disc degeneration is strongly associated with low back pain. Cell transplantation has been extensively studied as a treatment…”
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Cobalt-chromium versus titanium alloy rods for correction of adolescent idiopathic scoliosis based on 1-year follow-up: a multicenter randomized controlled clinical trial by Sakai, Daisuke, Tanaka, Masato, Takahashi, Jun, Taniguchi, Yuki, Schol, Jordy, Hiyama, Akihiko, Misawa, Haruo, Kuraishi, Shugo, Oba, Hiroki, Matsubayashi, Yoshitaka, Kato, So, Sugawara, Ryo, Sato, Masato, Watanabe, Masahiko, Takeshita, Katsushi

“…For instrumented correction surgery for adolescent idiopathic scoliosis (AIS), surgeons are increasingly switching from titanium (Ti) alloy rods to stiffer…”
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Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study by Schol, Jordy, Sakai, Daisuke, Warita, Takayuki, Nukaga, Tadashi, Sako, Kosuke, Wangler, Sebastian, Tamagawa, Shota, Zeiter, Stephan, Alini, Mauro, Grad, Sibylle

“…Introduction Cell transplantation shows promising results for intervertebral disc (IVD) repair, however, contemporary strategies present concerns regarding…”
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Threats and opportunities of using ChatGPT in scientific writing—The risk of getting spineless by Ambrosio, Luca, Schol, Jordy, La Pietra, Vincenzo Amedeo, Russo, Fabrizio, Vadalà, Gianluca, Sakai, Daisuke

“…ChatGPT and AI chatbots are revolutionizing several science fields, including medical writing. However, the inadequate use of such advantageous tools can raise…”
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Annulus fibrosus cell sheets limit disc degeneration in a rat annulus fibrosus injury model by Nukaga, Tadashi, Sakai, Daisuke, Schol, Jordy, Sato, Masato, Watanabe, Masahiko

“…In recent years, studies have explored novel approaches for cell transplantation to enable annulus fibrosus (AF) regeneration of the intervertebral disc in…”
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Optimization of Spheroid Colony Culture and Cryopreservation of Nucleus Pulposus Cells for the Development of Intervertebral Disc Regenerative Therapeutics by Sako, Kosuke, Sakai, Daisuke, Nakamura, Yoshihiko, Matsushita, Erika, Schol, Jordy, Warita, Takayuki, Horikita, Natsumi, Sato, Masato, Watanabe, Masahiko

“…After the discovery of functionally superior Tie2-positive nucleus pulposus (NP) progenitor cells, new methods were needed to enable mass culture and…”
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Screening for Growth-Factor Combinations Enabling Synergistic Differentiation of Human MSC to Nucleus Pulposus Cell-Like Cells by Morita, Kosuke, Schol, Jordy, Volleman, Tibo N. E., Sakai, Daisuke, Sato, Masato, Watanabe, Masahiko

“…Background: Multiple studies have examined the potential of growth factors (GF) to enable mesenchymal stromal cells (MSC) to nucleus pulposus (NP) cell-like…”
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Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review by Volleman, Tibo Nico Emmie, Schol, Jordy, Morita, Kosuke, Sakai, Daisuke, Watanabe, Masahiko

“…Low back pain remains a highly prevalent pathology engendering a tremendous socioeconomic burden. Low back pain is generally associated with intervertebral…”
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