Search Results - "Schoijet, Alejandra"

Signal Transduction Pathways as Therapeutic Target for Chagas Disease by Schoijet, Alejandra Cecilia, Sternlieb, Tamara, Alonso, Guillermo Daniel

“…Trypanosomatids are a group of flagellated unicellular eukaryotes, causing serious human diseases including Chagas disease (Trypanosoma cruzi), sleeping…”
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An AMP-activated protein kinase complex with two distinctive alpha subunits is involved in nutritional stress responses in Trypanosoma cruzi by Sternlieb, Tamara, Schoijet, Alejandra C, Genta, Patricio D, Vilchez Larrea, Salomé C, Alonso, Guillermo D

“…Trypanosoma cruzi , the etiological agent of Chagas disease, has a digenetic life cycle. In its passage from the insect vector to the mammalian host, and vice…”
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Methods to Investigate Signal Transduction Pathways in Trypanosoma cruzi: Cyclic Nucleotide Phosphodiesterases Assay Protocols by Schoijet, Alejandra C, Sternlieb, Tamara, Alonso, Guillermo D

“…Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the…”
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Intracellular cyclic AMP levels modulate differential adaptive responses on epimastigotes and cell culture trypomastigotes of Trypanosoma cruzi by Sternlieb, Tamara, Schoijet, Alejandra C., Alonso, Guillermo D.

“…•cAMP analogs can improve epimastigote resistance to oxidative stress.•TcrPDEA1 is involved in oxidative stress response in T. cruzi.•cAMP treatment on…”
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The Phosphatidylinositol 3‐kinase Class III Complex Containing TcVps15 and TcVps34 Participates in Autophagy in Trypanosoma cruzi by Schoijet, Alejandra C., Sternlieb, Tamara, Alonso, Guillermo D.

“…Autophagy is a degradative process by which eukaryotic cells digest their own components to provide aminoacids that may function as energy source under…”
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Venom alkaloids against Chagas disease parasite: search for effective therapies by Silva, Rafael C. M. Costa, Fox, Eduardo G. P., Gomes, Fabio M., Feijó, Daniel F., Ramos, Isabela, Koeller, Carolina M., Costa, Tatiana F. R., Rodrigues, Nathalia S., Lima, Ana P., Atella, Georgia C., Miranda, Kildare, Schoijet, Alejandra C., Alonso, Guillermo D., de Alcântara Machado, Ednildo, Heise, Norton

“…Chagas disease is an important disease affecting millions of patients in the New World and is caused by a protozoan transmitted by haematophagous kissing bugs…”
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TbVps15 is required for vesicular transport and cytokinesis in Trypanosoma brucei by Schoijet, Alejandra C., Miranda, Kildare, Sternlieb, Tamara, Barrera, Nadia M., Girard-Dias, Wendell, de Souza, Wanderley, Alonso, Guillermo D.

“…Knockdown of the kinase TbVps15 expression by RNAi causes a blockage of cytokinesis and an impairment of vesicular transport to the lysosome in Trypanosoma…”
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Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1 by Llanos, Manuel A., Alberca, Lucas N., Larrea, Salomé C. Vilchez, Schoijet, Alejandra C., Alonso, Guillermo D., Bellera, Carolina L., Gavenet, Luciana, Talevi, Alan

“…Cyclic nucleotide phosphodiesterases have been implicated in the proliferation, differentiation and osmotic regulation of trypanosomatids; in some…”
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Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi by Schoijet, Alejandra C., Miranda, Kildare, Medeiros, Lia Carolina Soares, de Souza, Wanderley, Flawiá, Mirtha M., Torres, Héctor N., Pignataro, Omar P., Docampo, Roberto, Alonso, Guillermo D.

“…Summary Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs)…”
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TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi by Alonso, Guillermo D., Schoijet, Alejandra C., Torres, Héctor N., Flawiá, Mirtha M.

“…Cyclic nucleotide phosphodiesterases (PDEs) catalyze the degradation of cAMP and cGMP, and regulate a variety of cellular processes by controlling the levels…”
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Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes by Gimenez, Alba Marina, Gesumaría, María Celeste, Schoijet, Alejandra C., Alonso, Guillermo D., Flawiá, Mirtha M., Racagni, Graciela E., Machado, Estela E.

“…[Display omitted] •Biochemical characterization of phosphoinositide kinases of T. cruzi.•Inhibition of PI3K affects the normal growth of…”
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A Trypanosoma cruzi Phosphatidylinositol 3-Kinase (TcVps34) Is Involved in Osmoregulation and Receptor-mediated Endocytosis by Schoijet, Alejandra C., Miranda, Kildare, Girard-Dias, Wendell, de Souza, Wanderley, Flawiá, Mirtha M., Torres, Héctor N., Docampo, Roberto, Alonso, Guillermo D.

“…Trypanosoma cruzi, the etiological agent of Chagas disease, has the ability to respond to a variety of environmental changes during its life cycle both in the…”
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TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi by Alonso, Guillermo D., Schoijet, Alejandra C., Torres, Héctor N., Flawiá, Mirtha M.

“…Cyclic nucleotide phosphodiesterases constitute the only known mechanism to inactivate regulatory signals involving cAMP or cGMP. In our laboratory a…”
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Immobilized Escherichia coli BL21 as a Catalyst for the Synthesis of Adenine and Hypoxanthine Nucleosides by Trelles, Jorge A., Bentancor, Leticia, Schoijet, Alejandra, Porro, Silvia, Lewkowicz, Elizabeth S., Sinisterra, José V., Iribarren, Adolfo M.

“…Different supports, such as alginate, agar, agarose, and polyacrylamide, were used to immobilize Escherichia coli BL 21 by entrapment techniques. The…”
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Quantitative assessment of the nanoanatomy of the contractile vacuole complex in Trypanosoma cruzi by Augusto, Ingrid, Girard-Dias, Wendell, Schoijet, Alejandra, Alonso, Guillermo Daniel, Portugal, Rodrigo V, de Souza, Wanderley, Jimenez, Veronica, Miranda, Kildare

“…uses various mechanisms to cope with osmotic fluctuations during infection, including the remodeling of organelles such as the contractile vacuole complex…”
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Cyclic AMP pathway and endocytic mechanisms in Trypanosomatids by Torres, Héctor N., Schoijet, Alejandra C., Docampo, Roberto, Flawiá, Mirtha M., Alonso, Guillermo D.

“…Abstract only Several species of kinetoplastids cause major human infectious diseases. Trypanosoma cruzi is responsible of the fatal Chagas disease in South…”
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A Trypanosoma cruzi Phosphatidylinositol 3-Kinase (TcVps34) Is Involved in Osmoregulation and Receptor-mediated EndocytosisS by Schoijet, Alejandra C., Miranda, Kildare, Girard-Dias, Wendell, de Souza, Wanderley, Flawiá, Mirtha M., Torres, Héctor N., Docampo, Roberto, Alonso, Guillermo D.

“…Trypanosoma cruzi , the etiological agent of Chagas disease, has the ability to respond to a variety of environmental changes during its life cycle both in the…”
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