Search Results - "Schofield, Peter"

Genetics of dementia by Loy, Clement T, FRACP, Schofield, Peter R, Prof, Turner, Anne M, FRACP, Kwok, John BJ, Dr

“…Summary 25% of all people aged 55 years and older have a family history of dementia. For most, the family history is due to genetically complex disease, where…”
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Comment: Type 1 diabetes, traumatic brain injury, and dementia: Interactions or just bad luck? by Schofield, Peter W

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Specific and common genes implicated across major mental disorders: A review of meta-analysis studies by Gatt, Justine M, Burton, Karen L.O, Williams, Leanne M, Schofield, Peter R

“…Abstract Major efforts have been directed at family-based association and case–control studies to identify the involvement of candidate genes in the major…”
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Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease by Preische, Oliver, Schultz, Stephanie A., Apel, Anja, Kuhle, Jens, Kaeser, Stephan A., Barro, Christian, Gräber, Susanne, Kuder-Buletta, Elke, LaFougere, Christian, Laske, Christoph, Vöglein, Jonathan, Levin, Johannes, Masters, Colin L., Martins, Ralph, Schofield, Peter R., Rossor, Martin N., Graff-Radford, Neill R., Salloway, Stephen, Ghetti, Bernardino, Ringman, John M., Noble, James M., Chhatwal, Jasmeer, Goate, Alison M., Benzinger, Tammie L. S., Morris, John C., Bateman, Randall J., Wang, Guoqiao, Fagan, Anne M., McDade, Eric M., Gordon, Brian A., Jucker, Mathias

“…Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique…”
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White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network by Lee, Seonjoo, Viqar, Fawad, Zimmerman, Molly E., Narkhede, Atul, Tosto, Giuseppe, Benzinger, Tammie L.S., Marcus, Daniel S., Fagan, Anne M., Goate, Alison, Fox, Nick C., Cairns, Nigel J., Holtzman, David M., Buckles, Virginia, Ghetti, Bernardino, McDade, Eric, Martins, Ralph N., Saykin, Andrew J., Masters, Colin L., Ringman, John M., Ryan, Natalie S., Förster, Stefan, Laske, Christoph, Schofield, Peter R., Sperling, Reisa A., Salloway, Stephen, Correia, Stephen, Jack Jr, Clifford, Weiner, Michael, Bateman, Randall J., Morris, John C., Mayeux, Richard, Brickman, Adam M.

“…Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐weighted magnetic resonance imaging (MRI) scans that most commonly reflect…”
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Comprehensive cross-disorder analyses of CNTNAP2 suggest it is unlikely to be a primary risk gene for psychiatric disorders by Toma, Claudio, Pierce, Kerrie D, Shaw, Alex D, Heath, Anna, Mitchell, Philip B, Schofield, Peter R, Fullerton, Janice M

“…The contactin-associated protein-like 2 (CNTNAP2) gene is a member of the neurexin superfamily. CNTNAP2 was first implicated in the cortical dysplasia-focal…”
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Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease by Bateman, Randall J, Xiong, Chengjie, Benzinger, Tammie L.S, Fagan, Anne M, Goate, Alison, Fox, Nick C, Marcus, Daniel S, Cairns, Nigel J, Xie, Xianyun, Blazey, Tyler M, Holtzman, David M, Santacruz, Anna, Buckles, Virginia, Oliver, Angela, Moulder, Krista, Aisen, Paul S, Ghetti, Bernardino, Klunk, William E, McDade, Eric, Martins, Ralph N, Masters, Colin L, Mayeux, Richard, Ringman, John M, Rossor, Martin N, Schofield, Peter R, Sperling, Reisa A, Salloway, Stephen, Morris, John C

“…In this study of a cohort of adults with genetic mutations that cause autosomal dominant Alzheimer's disease, researchers identified abnormalities in…”
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Does Traumatic Brain Injury Lead to Criminality? A Whole-Population Retrospective Cohort Study Using Linked Data by Schofield, Peter W, Malacova, Eva, Preen, David B, D'Este, Catherine, Tate, Robyn, Reekie, Joanne, Wand, Handan, Butler, Tony

“…Traumatic brain injury (TBI) may be a risk factor for criminal behaviour however multiple factors potentially confound the association. Record linkage and Cox…”
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White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease by Araque Caballero, Miguel Ángel, Suárez-Calvet, Marc, Duering, Marco, Franzmeier, Nicolai, Benzinger, Tammie, Fagan, Anne M, Bateman, Randall J, Jack, Clifford R, Levin, Johannes, Dichgans, Martin, Jucker, Mathias, Karch, Celeste, Masters, Colin L, Morris, John C, Weiner, Michael, Rossor, Martin, Fox, Nick C, Lee, Jae-Hong, Salloway, Stephen, Danek, Adrian, Goate, Alison, Yakushev, Igor, Hassenstab, Jason, Schofield, Peter R, Haass, Christian, Ewers, Michael

“…See Jacobs and Buckley (doi:10.1093/brain/awy243) for a scientific commentary on this article. Despite the prevalence of white matter alterations in…”
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Bilingualism Does Not Alter Cognitive Decline or Dementia Risk Among Spanish-Speaking Immigrants by Zahodne, Laura B, Schofield, Peter W, Farrell, Meagan T, Stern, Yaakov, Manly, Jennifer J

“…Objective: Clinic-based studies suggest that dementia is diagnosed at older ages in bilinguals compared with monolinguals. The current study sought to test…”
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Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: a systematic review and meta-analysis by Alex, Anu, Abbott, Kylie A, McEvoy, Mark, Schofield, Peter W, Garg, Manohar L

“…Abstract Context Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) are widely considered as nootropic agents that may be beneficial in reversing…”
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Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia by Huang, Lijia, Chardon, Jodi Warman, Carter, Melissa T, Friend, Kathie L, Dudding, Tracy E, Schwartzentruber, Jeremy, Zou, Ruobing, Schofield, Peter W, Douglas, Stuart, Bulman, Dennis E, Boycott, Kym M

“…Congenital nonprogressive spinocerebellar ataxia is characterized by early gross motor delay, hypotonia, gait ataxia, mild dysarthria and dysmetria. The…”
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Genome-wide association study reveals two new risk loci for bipolar disorder by Mühleisen, Thomas W., Leber, Markus, Schulze, Thomas G., Strohmaier, Jana, Degenhardt, Franziska, Treutlein, Jens, Mattheisen, Manuel, Forstner, Andreas J., Schumacher, Johannes, Breuer, René, Meier, Sandra, Herms, Stefan, Hoffmann, Per, Lacour, André, Witt, Stephanie H., Reif, Andreas, Müller-Myhsok, Bertram, Lucae, Susanne, Maier, Wolfgang, Schwarz, Markus, Vedder, Helmut, Kammerer-Ciernioch, Jutta, Pfennig, Andrea, Bauer, Michael, Hautzinger, Martin, Moebus, Susanne, Priebe, Lutz, Czerski, Piotr M., Hauser, Joanna, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Brennan, Paul, McKay, James D., Wright, Adam, Mitchell, Philip B., Fullerton, Janice M., Schofield, Peter R., Montgomery, Grant W., Medland, Sarah E., Gordon, Scott D., Martin, Nicholas G., Krasnow, Valery, Chuchalin, Alexander, Babadjanova, Gulja, Pantelejeva, Galina, Abramova, Lilia I., Tiganov, Alexander S., Polonikov, Alexey, Khusnutdinova, Elza, Alda, Martin, Grof, Paul, Rouleau, Guy A., Turecki, Gustavo, Laprise, Catherine, Rivas, Fabio, Mayoral, Fermin, Kogevinas, Manolis, Grigoroiu-Serbanescu, Maria, Propping, Peter, Becker, Tim, Rietschel, Marcella, Nöthen, Markus M., Cichon, Sven

“…Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common…”
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Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation by Chatterjee, Pratishtha, Tegg, Michelle, Pedrini, Steve, Fagan, Anne M, Xiong, Chengjie, Singh, Abhay K, Taddei, Kevin, Gardener, Samantha, Masters, Colin L, Schofield, Peter R, Multhaup, Gerhard, Benzinger, Tammie L S, Morris, John C, Bateman, Randall J, Greenberg, Steven M, van Buchem, Mark A, Stoops, Erik, Vanderstichele, Hugo, Teunissen, Charlotte E, Hankey, Graeme J, Wermer, Marieke J H, Sohrabi, Hamid R, Martins, Ralph N, The Dominantly Inherited Alzheimer Network

“…Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been…”
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Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study by Gordon, Brian A, Blazey, Tyler M, Su, Yi, Hari-Raj, Amrita, Dincer, Aylin, Flores, Shaney, Christensen, Jon, McDade, Eric, Wang, Guoqiao, Xiong, Chengjie, Cairns, Nigel J, Hassenstab, Jason, Marcus, Daniel S, Fagan, Anne M, Jack, Clifford R, Hornbeck, Russ C, Paumier, Katrina L, Ances, Beau M, Berman, Sarah B, Brickman, Adam M, Cash, David M, Chhatwal, Jasmeer P, Correia, Stephen, Förster, Stefan, Fox, Nick C, Graff-Radford, Neill R, la Fougère, Christian, Levin, Johannes, Masters, Colin L, Rossor, Martin N, Salloway, Stephen, Saykin, Andrew J, Schofield, Peter R, Thompson, Paul M, Weiner, Michael M, Holtzman, David M, Raichle, Marcus E, Morris, John C, Bateman, Randall J, Benzinger, Tammie L S

“…Models of Alzheimer's disease propose a sequence of amyloid β (Aβ) accumulation, hypometabolism, and structural decline that precedes the onset of clinical…”
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Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease by McDade, Eric, Wang, Guoqiao, Gordon, Brian A, Hassenstab, Jason, Benzinger, Tammie L.S, Buckles, Virginia, Fagan, Anne M, Holtzman, David M, Cairns, Nigel J, Goate, Alison M, Marcus, Daniel S, Morris, John C, Paumier, Katrina, Xiong, Chengjie, Allegri, Ricardo, Berman, Sarah B, Klunk, William, Noble, James, Ringman, John, Ghetti, Bernardino, Farlow, Martin, Sperling, Reisa A, Chhatwal, Jasmeer, Salloway, Stephen, Graff-Radford, Neill R, Schofield, Peter R, Masters, Colin, Rossor, Martin N, Fox, Nick C, Levin, Johannes, Jucker, Mathias, Bateman, Randall J

“…OBJECTIVETo assess the onset, sequence, and rate of progression of comprehensive biomarker and clinical measures across the spectrum of Alzheimer disease (AD)…”
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The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease by Franzmeier, Nicolai, Ren, Jinyi, Damm, Alexander, Monté-Rubio, Gemma, Boada, Mercè, Ruiz, Agustín, Ramirez, Alfredo, Jessen, Frank, Düzel, Emrah, Rodríguez Gómez, Octavio, Benzinger, Tammie, Goate, Alison, Karch, Celeste M., Fagan, Anne M., McDade, Eric, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Suárez-Calvet, Marc, Haass, Christian, Gordon, Brian A., Lim, Yen Ying, Masters, Colin L., Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Milz, Esther, Moreno-Grau, Sonia, Teipel, Stefan, Grothe, Michel J, Kilimann, Ingo, Rossor, Martin, Fox, Nick, Laske, Christoph, Chhatwal, Jasmeer, Falkai, Peter, Perneczky, Robert, Lee, Jae-Hong, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Fliessbach, Klaus, Heneka, Michael T., Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J., Franke, Christiana, Schneider, Anja, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Araque Caballero, Miguel Ángel, Metzger, Coraline, Bittner, Daniel, Salloway, Stephen, Danek, Adrian, Hassenstab, Jason, Yakushev, Igor, Schofield, Peter R., Morris, John C., Bateman, Randall J., Ewers, Michael

“…In Alzheimer’s disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor ( BDNF Val66Met ) is associated with worse…”
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Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis by Ryman, Davis C, Acosta-Baena, Natalia, Aisen, Paul S, Bird, Thomas, Danek, Adrian, Fox, Nick C, Goate, Alison, Frommelt, Peter, Ghetti, Bernardino, Langbaum, Jessica B.S, Lopera, Francisco, Martins, Ralph, Masters, Colin L, Mayeux, Richard P, McDade, Eric, Moreno, Sonia, Reiman, Eric M, Ringman, John M, Salloway, Steve, Schofield, Peter R, Sperling, Reisa, Tariot, Pierre N, Xiong, Chengjie, Morris, John C, Bateman, Randall J

“…OBJECTIVE:To identify factors influencing age at symptom onset and disease course in autosomal dominant Alzheimer disease (ADAD), and develop evidence-based…”
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Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease by Benzinger, Tammie L S, Blazey, Tyler, Jack, Jr, Clifford R, Koeppe, Robert A, Su, Yi, Xiong, Chengjie, Raichle, Marcus E, Snyder, Abraham Z, Ances, Beau M, Bateman, Randall J, Cairns, Nigel J, Fagan, Anne M, Goate, Alison, Marcus, Daniel S, Aisen, Paul S, Christensen, Jon J, Ercole, Lindsay, Hornbeck, Russ C, Farrar, Angela M, Aldea, Patricia, Jasielec, Mateusz S, Owen, Christopher J, Xie, Xianyun, Mayeux, Richard, Brickman, Adam, McDade, Eric, Klunk, William, Mathis, Chester A, Ringman, John, Thompson, Paul M, Ghetti, Bernardino, Saykin, Andrew J, Sperling, Reisa A, Johnson, Keith A, Salloway, Stephen, Correia, Stephen, Schofield, Peter R, Masters, Colin L, Rowe, Christopher, Villemagne, Victor L, Martins, Ralph, Ourselin, Sebastien, Rossor, Martin N, Fox, Nick C, Cash, David M, Weiner, Michael W, Holtzman, David M, Buckles, Virginia D, Moulder, Krista, Morris, John C

“…Major imaging biomarkers of Alzheimer’s disease include amyloid deposition [imaged with [ ¹¹C]Pittsburgh compound B (PiB) PET], altered glucose metabolism…”
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Ethnic density, urbanicity and psychosis risk for migrant groups – A population cohort study by Schofield, Peter, Thygesen, Malene, Das-Munshi, Jay, Becares, Laia, Cantor-Graae, Elizabeth, Pedersen, Carsten, Agerbo, Esben

“…Abstract Background Rates of psychotic disorder are raised for many migrant groups. Understanding the role played by the social context in which they live may…”
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