Search Results - "Schofield, Mark J"

DNA MISMATCH REPAIR: Molecular Mechanisms and Biological Function by Schofield, Mark J, Hsieh, Peggy

“…DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells. It contributes about 1000-fold to the overall fidelity of replication and…”
Get full text

DNA Bending and Unbending by MutS Govern Mismatch Recognition and Specificity by Wang, Hong, Yang, Yong, Schofield, Mark J., Du, Chunwei, Fridman, Yonatan, Lee, Susan D., Larson, Erik D., Drummond, James T., Alani, Eric, Hsieh, Peggy, Erie, Dorothy A.

“…DNA mismatch repair is central to the maintenance of genomic stability. It is initiated by the recognition of base-base mismatches and insertion/deletion loops…”
Get full text

TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins by SZABADY, Rose L, YANTA, Joseph H, HALLADIN, David K, SCHOFIELD, Mark J, WELCH, Rodney A

“…Vibrio cholerae is a human diarrhoeal pathogen that is a major cause of gastrointestinal disease and death worldwide. Pathogenic V. cholerae strains are…”
Get full text

Interaction of Escherichia coli MutS and MutL at a DNA Mismatch by Schofield, M J, Nayak, S, Scott, T H, Du, C, Hsieh, P

“…MutS and MutL are both required to activate downstream events in DNA mismatch repair. We examined the rate of dissociation of MutS from a mismatch using linear…”
Get full text

Formation of a DNA mismatch repair complex mediated by ATP by Selmane, Tassadite, Schofield, Mark J, Nayak, Sunil, Du, Chunwei, Hsieh, Peggy

“…The mismatch repair proteins, MutS and MutL, interact in a DNA mismatch and ATP-dependent manner to activate downstream events in repair. Here, we assess the…”
Get full text

Crystal Structure and Biochemical Analysis of the MutS·ADP·Beryllium Fluoride Complex Suggests a Conserved Mechanism for ATP Interactions in Mismatch Repair by Alani, Eric, Lee, Jae Young, Schofield, Mark J., Kijas, Amanda W., Hsieh, Peggy, Yang, Wei

Get full text

Requirement for Phe36 for DNA binding and mismatch repair by Escherichia coli MutS protein by Yamamoto, A, Schofield, M J, Biswas, I, Hsieh, P

“…The MutS family of DNA repair proteins recognizes base pair mismatches and insertion/deletion mismatches and targets them for repair in a strand-specific…”
Get full text

Yeast Resolving Enzyme CCE1 Makes Sequential Cleavages in DNA Junctions within the Lifetime of the Complex by Fogg, Jonathan M, Schofield, Mark J, Déclais, Anne-Cécile, Lilley, David M. J

“…CCE1 is a DNA junction-resolving enzyme of Saccharomyces cerevisiae. Such enzymes are required to make two symmetrically paired cleavages in order to resolve…”
Get full text

Dissection of the Sequence Specificity of the Holliday Junction Endonuclease CCE1 by Schofield, Mark J, Lilley, David M. J, White, Malcolm F

“…CCE1 is a Holliday (four-way DNA) junction-specific endonuclease which resolves mitochondrial DNA recombination intermediates in Saccharomyces cerevisiae. The…”
Get full text

Sequence and Functional-Group Specificity for Cleavage of DNA Junctions by RuvC of Escherichia coli by Fogg, Jonathan M, Schofield, Mark J, White, Malcolm F, Lilley, David M. J

“…RuvC is the DNA junction-resolving enzyme of Escherichia coli. While the enzyme binds to DNA junctions independently of base sequence, it exhibits considerable…”
Get full text

The Phe-X-Glu DNA Binding Motif of MutS by Schofield, Mark J., Brownewell, Floyd E., Nayak, Sunil, Du, Chunwei, Kool, Eric T., Hsieh, Peggy

“…The crystal structures of MutS protein fromThermus aquaticus and Escherichia coli in a complex with a mismatch-containing DNA duplex reveal that the Glu…”
Get full text

Dissection of the Sequence Specificity of the Holliday Junction Endonuclease CCE1 by Schofield, Mark J, Lilley, David M. J, White, Malcolm F

Get full text

DNA mismatch repair: Molecular mechanisms and biology function by Schofield, Mark J, Hsieh, Peggy

“…DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells. It contributes about 1000-fold to the overall fidelity of replication and…”
Get full text

The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen bonding in mismatch recognition by Schofield, M J, Brownewell, F E, Nayak, S, Du, C, Kool, E T, Hsieh, P

“…The crystal structures of MutS protein from Thermus aquaticus and Escherichia coli in a complex with a mismatch-containing DNA duplex reveal that the Glu…”
Get full text

Crystal Structure and Biochemical Analysis of the MutS·ADP·Beryllium Fluoride Complex Suggests a Conserved Mechanism for ATP Interactions in Mismatch Repair by Eric Alani, Jae Young Lee, Mark J. Schofield, Amanda W. Kijas, Peggy Hsieh, Wei Yang

“…During mismatch repair ATP binding and hydrolysis activities by the MutS family proteins are important for both mismatch recognition and for transducing…”
Get full text

Crystal Structure and Biochemical Analysis of the MutS·ADP·Beryllium Fluoride Complex Suggests a Conserved Mechanism for ATP Interactions in Mismatch Repair210 by Alani, Eric, Lee, Jae Young, Schofield, Mark J., Kijas, Amanda W., Hsieh, Peggy, Yang, Wei

“…During mismatch repair ATP binding and hydrolysis activities by the MutS family proteins are important for both mismatch recognition and for transducing…”
Get full text

Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair by Alani, Eric, Lee, Jae Young, Schofield, Mark J, Kijas, Amanda W, Hsieh, Peggy, Yang, Wei

“…During mismatch repair ATP binding and hydrolysis activities by the MutS family proteins are important for both mismatch recognition and for transducing…”
Get full text

The recombinant protein array: use in target identification and validation by Schofield, Mark J., Sharma, Neil, Ge, Hui

“…The human genome contains ∼30,000 genes, but it is proposed that these genes could encode up to a million different proteins. Alternative splicing of genes…”
Get full text