Search Results - "Schoepp, Darryle"

mGlu2/3 receptor agonist (LY354740) in anxiety by Schoepp, Darryle D.

“…mGlu2/3 Receptors (LY354740) in Anxiety mGlu2/3 receptors when activated decrease glutamate excitation on limbic synapses involved in anxiety. The orally…”
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial by Martenyi, Ferenc, Monn, James A, Patil, Sandeep T, Zhang, Lu, Lowe, Stephen L, Jackson, Kimberley A, Andreev, Boris V, Avedisova, Alla S, Bardenstein, Leonid M, Gurovich, Issak Y, Morozova, Margarita A, Mosolov, Sergey N, Neznanov, Nikolai G, Reznik, Alexander M, Smulevich, Anatoly B, Tochilov, Vladimir A, Johnson, Bryan G, Schoepp, Darryle D

“…Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within…”
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CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography by Wright, Rebecca A., Johnson, Bryan G., Zhang, Ce, Salhoff, Craig, Kingston, Ann E., Calligaro, David O., Monn, James A., Schoepp, Darryle D., Marek, Gerard J.

“…Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety…”
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Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039) by Fell, Matthew J, Svensson, Kjell A, Johnson, Bryan G, Schoepp, Darryle D

“…(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039) is a potent and selective group II metabotropic glutamate [(mGlu)2…”
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Efficacy and Tolerability of an mGlu2 3 Agonist in the Treatment of Generalized Anxiety Disorder by DUNAYEVICH, Eduardo, ERICKSON, Janelle, LEVINE, Louise, LANDBLOOM, Ronald, SCHOEPP, Darryle D, TOLLEFSON, Gary D

“…LY354740, a potent and selective mGlu (metabotropic glutamate receptor)2/3 agonist, has shown efficacy in the treatment of generalized anxiety disorder (GAD)…”
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Where will new neuroscience therapies come from? by Schoepp, Darryle D

“…The challenges of developing drugs for central nervous system disorders have led some major companies to reduce or discontinue investment in the field, even…”
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Metabotropic glutamate receptors in the control of mood disorders by Witkin, Jeffrey M, Marek, Gerard J, Johnson, Bryan G, Schoepp, Darryle D

“…Current treatments for depression are less than optimal in terms of onset of action, response and remission rates, and side-effect profiles. Glutamate is the…”
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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders by Schoepp, Darryle D, Swanson, Chad J, Bures, Mark, Johnson, Michael P, Linden, Anni-Maija, Monn, James A

“…Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and current treatments are less than satisfactory. So, the discovery of…”
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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo by Cirrito, John R., Yamada, Kelvin A., Finn, Mary Beth, Sloviter, Robert S., Bales, Kelly R., May, Patrick C., Schoepp, Darryle D., Paul, Steven M., Mennerick, Steven, Holtzman, David M.

“…Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is central to Alzheimer's disease pathogenesis. Aβ aggregation is…”
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Translating glutamate: from pathophysiology to treatment by Javitt, Daniel C, Schoepp, Darryle, Kalivas, Peter W, Volkow, Nora D, Zarate, Carlos, Merchant, Kalpana, Bear, Mark F, Umbricht, Daniel, Hajos, Mihaly, Potter, William Z, Lee, Chi-Ming

“…The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian brain and is responsible for most corticocortical and corticofugal…”
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Metabotropic glutamate receptors, 5 years on by Collingridge, Graham L., Manahan-Vaughan, Denise, Nicoletti, Ferdinando, Schoepp, Darryle D.

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders by RORICK-KEHN, Linda M, JOHNSON, Bryan G, SCHOEPP, Darryle D, KNITOWSKI, Karen M, SALHOFF, Craig R, WITKIN, Jeffrey M, PERRY, Kenneth W, GRIFFEY, Kelly I, TIZZANO, Joseph P, MONN, James A, MCKINZIE, David L

“…Data from both preclinical and clinical studies have provided proof of concept that modulation of limbic and forebrain glutamate, via mGlu2/3 receptor…”
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Alzheimer's disease research and development: a call for a new research roadmap by Feldman, Howard H., Haas, Magali, Gandy, Sam, Schoepp, Darryle D., Cross, Alan J., Mayeux, Richard, Sperling, Reisa A., Fillit, Howard, van de Hoef, Diana L., Dougal, Sonya, Nye, Jeffrey S.

“…Epidemiological projections of the prevalence of Alzheimer's disease (AD) and related dementias, the rapidly expanding population over the age of 65, and the…”
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Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system by Schoepp, D D

“…Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein-coupled receptors which function to modulate…”
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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) by Johnson, Michael P, Barda, David, Britton, Thomas C, Emkey, Renee, Hornback, William J, Jagdmann, G Erik, McKinzie, David L, Nisenbaum, Eric S, Tizzano, Joseph P, Schoepp, Darryle D

“…To increase subtype selectivity and provide a novel means to alter receptor function, we discovered and characterization potentiators for the metabotropic…”
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Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine by Johnson, Michael P, Baez, Melvyn, Jagdmann, G. Erik, Britton, Thomas C, Large, Thomas H, Callagaro, David O, Tizzano, Joseph P, Monn, James A, Schoepp, Darryle D

“…This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3)…”
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Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039) by Rorick-Kehn, Linda M, Johnson, Bryan G, Burkey, Jennifer L, Wright, Rebecca A, Calligaro, David O, Marek, Gerard J, Nisenbaum, Eric S, Catlow, John T, Kingston, Ann E, Giera, Deborah D, Herin, Marc F, Monn, James A, McKinzie, David L, Schoepp, Darryle D

“…Group II metabotropic glutamate (mGlu) receptor agonists, including (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and…”
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Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia? by DD, Darryle D Schoepp, Marek, Gerard J

“…Agonists for mGlu2/3 receptors decrease the evoked release of glutamate at certain (ie. forebrain / limbic) glutamatergic synapses, indicating that the…”
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Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus by Linden, Anni-Maija, Baez, Melvin, Bergeron, Marcelle, Schoepp, Darryle D.

“…LY354740 is a potent and selective mGlu2/3 receptor agonist with activity in models of psychiatric disorders (anxiety, psychosis), and early clinical studies…”
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Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors by Cartmell, Jayne, Schoepp, Darryle D.

“…: The G protein‐coupled metabotropic glutamate (mGlu) receptors are differentially localized at various synapses throughout the brain. Depending on the…”
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