Search Results - "Schoen, Robert E"
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Cost-Effectiveness and National Effects of Initiating Colorectal Cancer Screening for Average-Risk Persons at Age 45 Years Instead of 50 Years
Published in Gastroenterology (New York, N.Y. 1943) (01-07-2019)“…The American Cancer Society has recommended initiating colorectal cancer (CRC) screening at age 45 years instead of 50 years. We estimated the cost…”
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Journal Article -
2
World Endoscopy Organization Consensus Statements on Post-Colonoscopy and Post-Imaging Colorectal Cancer
Published in Gastroenterology (01-09-2018)“…Colonoscopy examination does not always detect colorectal cancer (CRC)— some patients develop CRC after negative findings from an examination. When this occurs…”
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Journal Article Conference Proceeding -
3
Circulating Myeloid Derived Suppressor Cells (MDSC) That Accumulate in Premalignancy Share Phenotypic and Functional Characteristics With MDSC in Cancer
Published in Frontiers in immunology (19-06-2019)“…Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that accumulate in circulation of cancer patients and at tumor…”
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4
Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors
Published in Gastroenterology (New York, N.Y. 1943) (01-06-2018)“…Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lifestyle, environmental, or genetic risk factors…”
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Journal Article -
5
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice
Published in The Journal of clinical investigation (01-05-2011)“…Intestinal epithelial cell (IEC) apoptosis contributes to the development of ulcerative colitis (UC), an inflammatory bowel disease (IBD) that affects the…”
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6
Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum
Published in mBio (06-04-2021)“…Aspirin is a chemopreventive agent for colorectal adenoma and cancer (CRC) that, like many drugs inclusive of chemotherapeutics, has been investigated for its…”
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7
A Model to Determine Colorectal Cancer Risk Using Common Genetic Susceptibility Loci
Published in Gastroenterology (New York, N.Y. 1943) (01-06-2015)“…Background & Aims Risk for colorectal cancer (CRC) can be greatly reduced through screening. To aid in the development of screening strategies, we refined…”
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Journal Article -
8
Estimating the heritability of colorectal cancer
Published in Human molecular genetics (15-07-2014)“…A sizable fraction of colorectal cancer (CRC) is expected to be explained by heritable factors, with heritability estimates ranging from 12 to 35% twin and…”
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Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study
Published in Gastrointestinal endoscopy (01-01-2010)“…Background Despite regular colonoscopy, interval colorectal cancer (CRC) may occur. Long-term studies examining CRC rates in patients with previous colonoscopy…”
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10
Pre-vaccination transcriptomic profiles of immune responders to the MUC1 peptide vaccine for colon cancer prevention
Published in Frontiers in immunology (10-10-2024)“…Self-antigens abnormally expressed on tumors, such as MUC1, have been targeted by therapeutic cancer vaccines. We recently assessed in two clinical trials in a…”
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Journal Article -
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Influence of Smoking, Body Mass Index, and Other Factors on the Preventive Effect of Nonsteroidal Anti-Inflammatory Drugs on Colorectal Cancer Risk
Published in Cancer research (Chicago, Ill.) (15-08-2018)“…Nonsteroidal anti-inflammatory drugs' (NSAID) use has consistently been associated with lower risk of colorectal cancer; however, studies showed inconsistent…”
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Strategies for Colorectal Cancer Screening
Published in Gastroenterology (New York, N.Y. 1943) (01-01-2020)“…The incidence of colorectal cancer (CRC) is increasing worldwide. CRC has high mortality when detected at advanced stages, yet it is also highly preventable…”
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13
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Published in BMC medicine (13-10-2023)“…Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote…”
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Journal Article -
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Public reporting of colonoscopy quality is associated with an increase in endoscopist adenoma detection rate
Published in Gastrointestinal endoscopy (01-10-2015)“…Background Colonoscopy is the predominant method for colorectal cancer screening in the United States. Previous studies have documented variation across…”
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Journal Article -
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Prospective Investigation of Body Mass Index, Colorectal Adenoma, and Colorectal Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Published in Journal of clinical oncology (01-07-2013)“…Obesity has consistently been linked to an increased risk of colorectal cancer, particularly among men. Whether body mass index (BMI) differentially influences…”
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Journal Article -
16
Adenoma Detection Rate Falls at the End of the Day in a Large Multi-site Sample
Published in Digestive diseases and sciences (01-04-2018)“…Background There is concern that mental and physical fatigue among endoscopists over the course of the day will lead to lower adenoma detection rate (ADR)…”
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eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis
Published in eLife (02-11-2020)“…To better understand a role of eIF4E S209 in oncogenic translation, we generated heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI…”
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Journal Article -
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Enrollee characteristics and receipt of colorectal cancer testing in Pennsylvania after adoption of the Affordable Care Act Medicaid expansion
Published in Cancer medicine (Malden, MA) (01-07-2023)“…Background Colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of cancer‐related death in the U.S. Despite increased CRC…”
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Journal Article -
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Applying a natural language processing tool to electronic health records to assess performance on colonoscopy quality measures
Published in Gastrointestinal endoscopy (01-06-2012)“…Background Gastroenterology specialty societies have advocated that providers routinely assess their performance on colonoscopy quality measures. Such routine…”
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Journal Article -
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Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
Published in Proceedings of the National Academy of Sciences - PNAS (16-11-2010)“…Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac effectively prevent colon cancer in humans and rodent models. However, their cellular targets…”
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