Search Results - "Schoemaker, R C"

Efficacy of 3,4-Diaminopyridine and Pyridostigmine in the Treatment of Lambert-Eaton Myasthenic Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study by Wirtz, PW, Verschuuren, JJ, Dijk, JG, Kam, ML, Schoemaker, RC, Hasselt, JGC, Titulaer, MJ, Tjaden, UR, Hartigh, J, Gerven, JMA

“…3,4‐Diaminopyridine and pyridostigmine are widely used to treat Lambert–Eaton myasthenic syndrome (LEMS), either alone or in combination. 3,4‐Diaminopyridine…”
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Effect of intrapulmonary tetrahydrocannabinol administration in humans by Zuurman, L., Roy, C., Schoemaker, RC, Hazekamp, A., den Hartigh, J., Bender, JCME, Verpoorte, R., Pinquier, JL, Cohen, AF, van Gerven, JMA

“…This randomised, double-blind, placebo-controlled, cross-over study was designed to identify which pharmacodynamic parameters most accurately quantify the…”
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Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects by de Haas, SL, Schoemaker, RC, van Gerven, JMA, Hoever, P, Cohen, AF, Dingemanse, J

“…Zolpidem is one of the most frequently prescribed hypnotics, as it is a very short-acting compound with relatively few side effects. Zolpidem’s short duration…”
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Pharmacokinetics and systemic endocrine effects of the phyto‐oestrogen 8‐prenylnaringenin after single oral doses to postmenopausal women by Rad, M., Hümpel, M., Schaefer, O., Schoemaker, R. C., Schleuning, W‐D., Cohen, A. F., Burggraaf, J.

“…Aims Pre‐clinical data suggest that the racemic phyto‐oestrogen 8‐prenylnaringenin (8‐PN) may have beneficial effects in postmenopausal women and may become an…”
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Modelling of the concentration—effect relationship of THC on central nervous system parameters and heart rate — insight into its mechanisms of action and a tool for clinical research and development of cannabinoids by Strougo, A., Zuurman, L., Roy, C., Pinquier, JL, van Gerven, JMA, Cohen, AF, Schoemaker, RC

“…Pharmacokinetics after pulmonary administration of δ-9-tetrahydrocannabinol (THC) and its major metabolites 11-OH-THC and 11-nor-9-COOH-THC was quantified…”
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Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625 by Zuurman, L., Roy, C., Schoemaker, RC, Amatsaleh, A., Guimaeres, L., Pinquier, JL, Cohen, AF, van Gerven, JMA

“…CB1 antagonists such as AVE1625 are potentially useful in the treatment of obesity, smoking cessation and cognitive impairment. Proof of pharmacological action…”
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Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol by Liem-Moolenaar, M., Gray, FA, de Visser, SJ, Franson, KL, Schoemaker, RC, Schmitt, JAJ, Cohen, AF, van Gerven, JMA

“…Central Nervous System (CNS) effects of talnetant, an NK-3 antagonist in development for schizophrenia, were compared to those of haloperidol and placebo. The…”
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Ciclosporin kinetics in children after stem cell transplantation by Willemze, A. J., Cremers, S. C., Schoemaker, R. C., Lankester, A. C., Den Hartigh, J., Burggraaf, J., Vossen, J. M.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Ciclosporin is an immunosuppressant drug that is commonly used as prophylaxis against graft‐versus‐host disease…”
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Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers by Dumont, GJH, Schoemaker, RC, Touw, DJ, Sweep, FCGJ, Buitelaar, JK, van Gerven, JMA, Verkes, RJ

“…In Western societies, a considerable percentage of young people use 3,4-methylenedioxymethamphetamine (MDMA or ‘ecstasy’). The use of alcohol (ethanol) in…”
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The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol by Zoethout, RWM, Iannone, R, Bloem, BR, Palcza, J, Murphy, G, Chodakewitz, J, Buntinx, A, Gottesdiener, K, Marsilio, S, Rosen, L, van Dyck, K, Louis, ED, Cohen, AF, Schoemaker, RC, Tokita, S, Sato, N, Koblan, KS, Hargreaves, RH, Renger, JJ, van Gerven, JMA

“…Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the…”
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Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology by Dumont, GJH, Kramers, C., Sweep, FCGJ, Willemsen, JJ, Touw, DJ, Schoemaker, RC, van Gerven, JMA, Buitelaar, JK, Verkes, RJ

“…Alcohol is frequently used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Both drugs affect cardiovascular function, hydration and temperature…”
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Pharmacokinetics of rectal tramadol in postoperative paediatric patients by Zwaveling, J., Bubbers, S., van Meurs, A.H.J., Schoemaker, R.C., van Heel, I. Ruijs-Dudok, Vermeij, P., Burggraaf, J.

“…Postoperative analgesia in children may be improved by using tramadol. The pharmacokinetics of rectal tramadol in young children were therefore investigated…”
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Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy by Broeyer, F. J. F., Osanto, S., Ritsema van Eck, H. J., van Steijn, A. Q. M. J., Ballieux, B. E. P. B., Schoemaker, R. C., Cohen, A. F., Burggraaf, J.

“…Introduction The clinical assessment of the myocardial damage caused by anthracyclin (ANT)-therapy is difficult. Therefore a study was performed to evaluate…”
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Sympathovagal imbalance in hyperthyroidism by Burggraaf, J, Tulen, J H, Lalezari, S, Schoemaker, R C, De Meyer, P H, Meinders, A E, Cohen, A F, Pijl, H

“…We assessed sympathovagal balance in thyrotoxicosis. Fourteen patients with Graves' hyperthyroidism were studied before and after 7 days of treatment with…”
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Cognitive performance and serotonergic function in users of ecstasy by VERKES, Robbert J, GIJSMAN, Harm J, COHEN, Adam F, PIETERS, Monique S. M, SCHOEMAKER, Rik C, DE VISSER, Saco, KUIJPERS, Monique, PENNINGS, Ed J. M, DE BRUIN, Dick, VAN DE WIJNGAART, Govert, VAN GERVEN, Joop M. A

“…(+/-) 3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") has been shown to cause long term damage to serotonergic cerebral neurons in animals. The…”
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The influence of cisapride and clarithromycin on QT intervals in healthy volunteers by Haarst, Aernout D., van't Klooster, Gerben A. E., Gerven, Joop M. A., Schoemaker, Rik C., Oene, Joop C., Burggraaf, Jacobus, Coene, Marie‐Claire, Cohen, Adam F.

“…Objective Recently a few cases of long QT syndrome were reported during treatment with cisapride. In most of these cases, risk factors for cardiac arrhythmias…”
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Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa by Smarius, LJCA, Jacobs, GE, Hoeberechts-Lefrandt, DHM, de Kam, ML, van der Post, JP, de Rijk, R, van Pelt, J, Schoemaker, RC, Zitman, FG, van Gerven, JMA, Gijsman, HJ

“…5-hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function. Its use has been limited by a narrow…”
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Orexin Receptor Antagonism, a New Sleep-Promoting Paradigm: An Ascending Single-Dose Study With Almorexant by Hoever, P, Haas, S, Winkler, J, Schoemaker, R C, Chiossi, E, Gerven, J, Dingemanse, J

“…Almorexant, a dual orexin receptor antagonist potentially representing a new class of sleep‐promoting compounds, was administered in an ascending single‐dose…”
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Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics by KREILGAARD, Mads, KEMME, Michiel J. B, BURGGRAAF, Jacobus, SCHOEMAKER, Rik C, COHEN, Adam F

“…The aim of the study was to investigate the cutaneous bioequivalence of a lipophilic model drug (lidocaine) applied in a novel topical microemulsion vehicle,…”
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High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection by Weijtens, Olga, Feron, Eric J, Schoemaker, Rik C, Cohen, Adam F, Lentjes, Eef G.W.M, Romijn, Fred P.H.T.M, van Meurs, Jan C

“…PURPOSE: To determine the dexamethasone concentration in aqueous, vitreous, and serum of patients after a subconjunctival injection with dexamethasone disodium…”
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