Search Results - "Schoch, Guillaume"

Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2 by Sansen, Stefaan, Yano, Jason K., Reynald, Rosamund L., Schoch, Guillaume A., Griffin, Keith J., Stout, C. David, Johnson, Eric F.

“…Microsomal cytochrome P450 family 1 enzymes play prominent roles in xenobiotic detoxication and procarcinogen activation. P450 1A2 is the principal cytochrome…”
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The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution by Yano, Jason K., Wester, Michael R., Schoch, Guillaume A., Griffin, Keith J., Stout, C. David, Johnson, Eric F.

“…The structure of P450 3A4 was determined by x-ray crystallography to 2.05-Å resolution. P450 3A4 catalyzes the metabolic clearance of a large number of…”
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Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations by Schoch, Guillaume A., D'Arcy, Brigitte, Stihle, Martine, Burger, Dominique, Bär, Dominik, Benz, Jörg, Thoma, Ralf, Ruf, Armin

“…Mifepristone is known to induce mixed passive antagonist, active antagonist, and agonist effects via the glucocorticoid receptor (GR) pathway. Part of the…”
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Evolution of a Novel Phenolic Pathway for Pollen Development by Matsuno,, Michiyo, Compagnon, Vincent, Schoch, Guillaume A, Schmitt, Martine, Debayle, Delphine, Bassard, Jean-Etienne, Pollet, Brigitte, Hehn, Alain, Heintz, Dimitri, Ullmann, Pascaline, Lapierre, Catherine, Bernier, François, Ehlting, Jürgen, Werck-Reichhart, Danièle

“…Metabolic plasticity, which largely relies on the creation of new genes, is an essential feature of plant adaptation and speciation and has led to the…”
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Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID by Schoch, Guillaume A, Yano, Jason K, Sansen, Stefaan, Dansette, Patrick M, Stout, C. David, Johnson, Eric F

“…Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein…”
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The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution by Wester, Michael R, Yano, Jason K, Schoch, Guillaume A, Yang, Christine, Griffin, Keith J, Stout, C David, Johnson, Eric F

“…The structure of human P450 2C9 complexed with flurbiprofen was determined to 2.0 Å by x-ray crystallography. In contrast to other structurally characterized…”
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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site by Schoch, Guillaume A, Yano, Jason K, Wester, Michael R, Griffin, Keith J, Stout, C David, Johnson, Eric F

“…A 2.7-Angstrom molecular structure of human microsomal cytochrome P450 2C8 (CYP2C8) was determined by x-ray crystallography. The membrane protein was modified…”
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Structural Diversity in the RGS Domain and Its Interaction with Heterotrimeric G Protein α-Subunits by Soundararajan, Meera, Willard, Francis S., Kimple, Adam J., Turnbull, Andrew P., Ball, Linda J., Schoch, Guillaume A., Gileadi, Carina, Fedorov, Oleg Y., Dowler, Elizabeth F., Higman, Victoria A., Hutsell, Stephanie Q., Sundström, Michael, Doyle, Declan A., Siderovski, David P.

“…Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of signaling initiated by G…”
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Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening by Seitz, Tobias, Thoma, Ralf, Schoch, Guillaume A., Stihle, Martine, Benz, Jörg, D'Arcy, Brigitte, Wiget, Andrea, Ruf, Armin, Hennig, Michael, Sterner, Reinhard

“…The human glucocorticoid receptor ligand-binding domain (hGR-LBD) is an important drug target for the treatment of various diseases. However, the low intrinsic…”
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CYP98A3 from Arabidopsis thaliana Is a 3′-Hydroxylase of Phenolic Esters, a Missing Link in the Phenylpropanoid Pathway by Schoch, Guillaume, Goepfert, Simon, Morant, Marc, Hehn, Alain, Meyer, Denise, Ullmann, Pascaline, Werck-Reichhart, Danièle

“…The 4- and 5-hydroxylations of phenolic compounds in plants are catalyzed by cytochrome P450 enzymes. The 3-hydroxylation step leading to the formation of…”
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Analysis of Human Cytochrome P450 2C8 Substrate Specificity Using a Substrate Pharmacophore and Site-Directed Mutants by Melet, Armelle, Marques-Soares, Cristina, Schoch, Guillaume A, Macherey, Anne-Christine, Jaouen, Maryse, Dansette, Patrick M, Sari, Marie-Agnès, Johnson, Eric F, Mansuy, Daniel

“…The structural determinants of substrate specificity of human liver cytochrome P450 2C8 (CYP2C8) were investigated using site-directed mutants chosen on the…”
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Catalytic activity, duplication and evolution of the CYP98 cytochrome P450 family in wheat by Morant, Marc, Schoch, Guillaume A, Ullmann, Pascaline, Ertunç, Tanya, Little, Dawn, Olsen, Carl Erik, Petersen, Maike, Negrel, Jonathan, Werck-Reichhart, Danièle

“…A burst of evolutionary duplication upon land colonization seems to have led to the large superfamily of cytochromes P450 in higher plants. Within this…”
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Structure of a 13-fold superhelix (almost) determined from first principles by Schoch, Guillaume A, Sammito, Massimo, Millán, Claudia, Usón, Isabel, Rudolph, Markus G

“…Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex…”
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Engineering of a Water-Soluble Plant Cytochrome P450, CYP73A1, and NMR-Based Orientation of Natural and Alternate Substrates in the Active Site by Guillaume A. Schoch, Roger Attias, Maya Belghazi, Dansette, Patrick M., Werck-Reichhart, Danièle

“…CYP73A1 catalyzes cinnamic acid hydroxylation, a reaction essential for the synthesis of lignin monomers and most phenolic compounds in higher plants. The…”
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The meta-hydroxylation step in the phenylpropanoid pathway: a new level of complexity in the pathway and its regulation by Schoch, Guillaume A., Morant, Marc, Abdulrazzak, Nawroz, Asnaghi, Carole, Goepfert, Simon, Petersen, Maike, Ullmann, Pascaline, Werck-Reichhart, Danièle

“…Together in silico and genetic mining approaches have recently designated the CYP98 family of plant cytochromes P450 as the family of enzymes that catalyzes…”
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Chemical Inactivation of the Cinnamate 4-Hydroxylase Allows for the Accumulation of Salicylic Acid in Elicited Cells by Guillaume A. Schoch, Nikov, Georgi N., Alworth, William L., Werck-Reichhart, Danièle

“…The cinnamate (CA) 4-hydroxylase (C4H) is a cytochrome P450 that catalyzes the second step of the main phenylpropanoid pathway, leading to the synthesis of…”
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Engineering of a water-soluble plant cytochrome P450, CYP73A1, and NMR-based orientation of natural and alternate substrates in the active site1 by Schoch, Guillaume A, Attias, Roger, Belghazi, Maya, Dansette, Patrick M, Werck-Reichhart, Daniele

“…CYP73A1 catalyzes cinnamic acid hydroxylation, a reaction essential for the synthesis of lignin monomers and most phenolic compounds in higher plants. The…”
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Determinants of Cytochrome P450 2C8 Substrate Binding by Schoch, Guillaume A., Yano, Jason K., Sansen, Stefaan, Dansette, Patrick M., Stout, C. David, Johnson, Eric F.

“…Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein…”
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Role of Unusual Amino Acid Residues in the Proximal and Distal Heme Regions of a Plant P450, CYP73A1 by Schalk, Michel, Nedelkina, Svetlana, Schoch, Guillaume, Batard, Yannick, Werck-Reichhart, Danièle

“…CYP73A1 is a typical plant P450 in terms of its function and primary sequence. The enzyme catalyzes the 4-hydroxylation of trans-cinnamic acid, the first…”
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Chemical Inactivation of the Cinnamate 4-Hydroxylase Allows for the Accumulation of Salicylic Acid in Elicited Cells1 by Schoch, Guillaume A, Nikov, Georgi N, Alworth, William L, Werck-Reichhart, Danièle

“…The cinnamate (CA) 4-hydroxylase (C4H) is a cytochrome P450 that catalyzes the second step of the main phenylpropanoid pathway, leading to the synthesis of…”
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