Search Results - "Schöneich, Christian"

Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects by Schöneich, Christian

“…Purpose: Therapeutic proteins are sensitive to photo-degradation by UV A and visible light. As none of the essential amino acids exhibits significant…”
Get full text

Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins by Schöneich, Christian

“…Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to…”
Get full text

Near UV and Visible Light-Induced Degradation of Bovine Serum Albumin and a Monoclonal Antibody Mediated by Citrate Buffer and Fe(III): Reduction vs Oxidation Pathways by Wu, Yaqi, Gardner, Reece, Schöneich, Christian

“…Light exposure during manufacturing, storage, and administration can lead to the photodegradation of therapeutic proteins. This photodegradation can be…”
Get full text

Near UV Photodegradation Mechanisms of Amino Acid Excipients: Formation of the Carbon Dioxide Radical Anion from Aspartate and Fe(III) by Zhang, Yilue, Wu, Yaqi, Schöneich, Christian

“…Carbon dioxide radical anion (•CO2 –) is a powerful reducing agent that can reduce protein disulfide bonds and convert molecular oxygen to superoxide…”
Get full text

Near UV and Visible Light Induce Iron-Dependent Photodegradation Reactions in Pharmaceutical Buffers: Mechanistic and Product Studies by Subelzu, Natalia, Schöneich, Christian

“…Near UV (λ = 320–400 nm) and visible light (λ = 400–800 nm) can lead to the oxidation of pharmaceutical proteins, which can affect efficiency and promote…”
Get full text

Primary Processes of Free Radical Formation in Pharmaceutical Formulations of Therapeutic Proteins by Schöneich, Christian

“…Oxidation represents a major pathway for the chemical degradation of pharmaceutical formulations. Few specific details are available on the mechanisms that…”
Get full text

Thiyl radicals and induction of protein degradation by Schöneich, Christian

“…Thiyl radicals are important intermediates in the redox biology and chemistry of thiols. These radicals can react via hydrogen transfer with various C-H bonds…”
Get more information

Coarse-Grained Molecular Dynamics Simulation of Heterogeneous Polysorbate 80 Surfactants and their Interactions with Small Molecules and Proteins by Lou, Hao, Wu, Yaqi, Kuczera, Krzysztof, Schöneich, Christian

“…Polysorbate 80 (PS80) is widely used in pharmaceutical formulations, and its commercial grades exhibit certain levels of structural heterogeneity. The…”
Get full text

Near UV and Visible Light Photodegradation in Solid Formulations: Generation of Carbon Dioxide Radical Anions from Citrate Buffer and Fe(III) by Espinoza Ballesteros, Maribel, Schöneich, Christian

“…Near UV and visible light photodegradation can target therapeutic proteins during manufacturing and storage. While the underlying photodegradation pathways are…”
Get full text

Visible Light Induces Site-Specific Oxidative Heavy Chain Fragmentation of a Monoclonal Antibody (IgG1) Mediated by an Iron(III)-Containing Histidine Buffer by Zhang, Yilue, Schöneich, Christian

“…Fragmentation of therapeutic monoclonal antibodies represents a critical quality attribute. Here, we report a novel visible light-induced heavy chain…”
Get full text

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences by Torosantucci, Riccardo, Schöneich, Christian, Jiskoot, Wim

“…Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage…”
Get full text

Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins by Werner, Benjamin Patrick, Schöneich, Christian, Winter, Gerhard

“…Prefilled syringes are a popular choice for the delivery of biopharmaceuticals. However, glass syringes might not be the optimal primary packaging material for…”
Get more information

Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease by Schöneich, Christian

“…The oxidation of methionine plays an important role in vivo, during biological conditions of oxidative stress, as well as for protein stability in vitro…”
Get full text

Photo-induced fragmentation of tyrosine side chains in IgG4-Fc: Effect of protein sequence, conformation and glycan structure by Schöneich, Christian

“…This account summarizes recent work on photo-induced side chain cleavage reactions of Tyr in IgG4-Fc. These processes are initiated via photo-ionization of Trp…”
Get full text

Molecular Dynamics Simulation of an Iron(III) Binding Site on the Fc Domain of IgG1 Relevant for Visible Light-Induced Protein Fragmentation by Lou, Hao, Zhang, Yilue, Kuczera, Krzysztof, Hageman, Michael J., Schöneich, Christian

“…Molecular dynamics simulations were employed to investigate the interaction between Fe­(III) and an iron-binding site composed of THR259, ASP252, and GLU261 on…”
Get full text

Near-UV and Visible Light Degradation of Iron (III)-Containing Citrate Buffer: Formation of Carbon Dioxide Radical Anion via Fragmentation of a Sterically Hindered Alkoxyl Radical by Zhang, Yilue, Richards, David S., Grotemeyer, Elizabeth N., Jackson, Timothy A., Schöneich, Christian

“…Citrate is a commonly used buffer in pharmaceutical formulations which forms complexes with adventitious metals such as Fe3+. Fe3+-citrate complexes can act as…”
Get full text

In-Depth Characterization of Acidic Variants Induced by Metal-Catalyzed Oxidation in a Recombinant Monoclonal Antibody by Yang, Yi, Zhang, Fan, Gan, Yutian, Zhang, Hui-Min, Liu, Peilu, Mah, Anna, Gennaro, Lynn, Schöneich, Christian

“…Characterization of antibody charge heterogeneity is an important task for antibody drug development. Recently, a correlation between acidic charge…”
Get full text

Photoinduced Tyrosine Side Chain Fragmentation in IgG4-Fc: Mechanisms and Solvent Isotope Effects by Kang, Huan, Tolbert, Thomas J, Schöneich, Christian

“…Immunoglobulin gamma (IgG) monoclonal antibodies (mAbs) are glycoproteins that have emerged as powerful and promising protein therapeutics. During the process…”
Get full text

The Storage and In-Use Stability of mRNA Vaccines and Therapeutics: Not A Cold Case by Oude Blenke, Erik, Örnskov, Eivor, Schöneich, Christian, Nilsson, Gunilla A, Volkin, David B, Mastrobattista, Enrico, Almarsson, Örn, Crommelin, Daan J A

“…The remarkable impact of mRNA vaccines on mitigating disease and improving public health has been amply demonstrated during the COVID-19 pandemic. Many new…”
Get more information

Comparison of Polysorbate 80 Hydrolysis and Oxidation on the Aggregation of a Monoclonal Antibody by Larson, Nicholas R, Wei, Yangjie, Prajapati, Indira, Chakraborty, Aishik, Peters, Bjorn, Kalonia, Cavan, Hudak, Suzanne, Choudhary, Sureshkumar, Esfandiary, Reza, Dhar, Prajna, Schöneich, Christian, Middaugh, C Russell

“…Polysorbates are used ubiquitously in protein therapeutic drugs to help minimize adsorption to surfaces and aggregation. It has been recognized that…”
Get more information