Search Results - "Schnurbein, Julia"

Positive effect of leptin substitution on mood and behaviour in patients with congenital leptin deficiency by Schnurbein, Julia, Remy, Miriam, Brandt, Stephanie, Manzoor, Jaida, Kohlsdorf, Katja, Mahmood, Saqib, Hebebrand, Johannes, Wabitsch, Martin

“…Summary Background States of starvation are characterized by reduced physical activity and social withdrawal. This has been suggested to be mediated at least…”
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Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI‐SDS—A case series by Brandt, Stephanie, Schnurbein, Julia, Lennerz, Belinda, Kohlsdorf, Katja, Vollbach, Heike, Denzer, Christian, Bode, Harald, Hebebrand, Johannes, Wabitsch, Martin

“…Summary Background The clinical phenotype of patients with monogenic obesity due to mutations in the leptin receptor (LEPR) or melanocortin 4 receptor (MC4R)…”
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Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution by Beghini, Marianna, Brandt, Stephanie, Körber, Ingrid, Kohlsdorf, Katja, Vollbach, Heike, Lennerz, Belinda, Denzer, Christian, Shalitin, Shlomit, Santini, Ferruccio, Blum, Werner F., von Schnurbein, Julia, Wabitsch, Martin

“…Background Evidence from in vitro and rodent studies suggests that leptin, a key signal of long-term energy reserves, promotes IGF1 synthesis and linear…”
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The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline by Brown, Rebecca J, Araujo-Vilar, David, Cheung, Pik To, Dunger, David, Garg, Abhimanyu, Jack, Michelle, Mungai, Lucy, Oral, Elif A, Patni, Nivedita, Rother, Kristina I, von Schnurbein, Julia, Sorkina, Ekaterina, Stanley, Takara, Vigouroux, Corinne, Wabitsch, Martin, Williams, Rachel, Yorifuji, Tohru

“…Objective: Lipodystrophy syndromes are extremely rare disorders of deficient body fat associated with potentially serious metabolic complications, including…”
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Leptin Is Not Essential for Obesity-Associated Hypertension by von Schnurbein, Julia, Manzoor, Jaida, Brandt, Stephanie, Denzer, Friederike, Kohlsdorf, Katja, Fischer-Posovszky, Pamela, Weißenberger, Mario, Frank-Podlech, Sabine, Mahmood, Saqib, Wabitsch, Martin

“…Background and Objective: Hyperleptinemia is supposed to play a causal role in the development of obesity-associated hypertension, possibly via increased…”
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Changes in Satiety Hormones in Response to Leptin Treatment in a Patient with Leptin Deficiency by Roth, Christian L, von Schnurbein, Julia, Elfers, Clinton, Moss, Anja, Wabitsch, Martin

“…We tested whether leptin treatment affects secretion of satiety-related gut peptides and brain-derived neurotrophic factor (BDNF), which is a regulator of…”
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Leptin Replacement Reestablishes Brain Insulin Action in the Hypothalamus in Congenital Leptin Deficiency by Frank-Podlech, Sabine, von Schnurbein, Julia, Veit, Ralf, Heni, Martin, Machann, Jürgen, Heinze, Jaana M, Kullmann, Stephanie, Manzoor, Jaida, Mahmood, Saqib, Häring, Hans-Ulrich, Preissl, Hubert, Wabitsch, Martin, Fritsche, Andreas

“…Human obesity is associated with impaired central insulin signaling, and in very rare cases, severe obesity can be caused by congenital leptin deficiency. In…”
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Lipodystrophy as a Late Effect after Stem Cell Transplantation by Tews, Daniel, Schulz, Ansgar, Denzer, Christian, von Schnurbein, Julia, Ceccarini, Giovanni, Debatin, Klaus-Michael, Wabitsch, Martin

“…Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy…”
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Classification of Congenital Leptin Deficiency by von Schnurbein, Julia, Zorn, Stefanie, Nunziata, Adriana, Brandt, Stephanie, Moepps, Barbara, Funcke, Jan-Bernd, Hussain, Khalid, Farooqi, I Sadaf, Fischer-Posovszky, Pamela, Wabitsch, Martin

“…Abstract Purpose Biallelic pathogenic leptin gene variants cause severe early-onset obesity usually associated with low or undetectable circulating leptin…”
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Relative leptin deficiency in children with severe early-onset obesity (SEOO) - results of the Early-onset Obesity and Leptin - German-Polish Study (EOL-GPS) by Zachurzok, Agnieszka, Ranke, Michael B, Flehmig, Bertram, Jakubek-Kipa, Katarzyna, Marcinkiewicz, Katarzyna, Mazur, Artur, Petriczko, Elzbieta, Pridzun, Lutz, von Schnurbein, Julia, Walczak, Mieczyslaw, Malecka-Tendera, Ewa, Wabitsch, Martin, Brandt, Stephanie

“…Background Severe early-onset obesity (SEOO) in children is a common feature of monogenic obesity. Gene defects of the leptin-melanocortin pathway can be…”
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IMPROVE 2022 International Meeting on Pathway‐Related Obesity: Vision of Excellence by Kühnen, Peter, Argente, Jesús, Clément, Karine, Dollfus, Hélène, Dubern, Béatrice, Farooqi, Sadaf, Groot, Corjan, Grüters, Annette, Holm, Jens‐Christian, Hopkins, Mark, Kleinendorst, Lotte, Körner, Antje, Meeker, David, Rydén, Mikael, Schnurbein, Julia, Tschöp, Matthias, Yeo, Giles S. H., Zorn, Stefanie, Wabitsch, Martin

“…Summary Nearly 90 clinicians and researchers from around the world attended the first IMPROVE 2022 International Meeting on Pathway‐Related Obesity. Delegates…”
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Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity by Funcke, Jan-Bernd, Moepps, Barbara, Roos, Julian, von Schnurbein, Julia, Verstraete, Kenneth, Fröhlich-Reiterer, Elke, Kohlsdorf, Katja, Nunziata, Adriana, Brandt, Stephanie, Tsirigotaki, Alexandra, Dansercoer, Ann, Suppan, Elisabeth, Haris, Basma, Debatin, Klaus-Michael, Savvides, Savvas N., Farooqi, I. Sadaf, Hussain, Khalid, Gierschik, Peter, Fischer-Posovszky, Pamela, Wabitsch, Martin

“…Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin…”
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Diagnostic and therapeutic odyssey of two patients with compound heterozygous leptin receptor deficiency by Zorn, Stefanie, von Schnurbein, Julia, Kohlsdorf, Katja, Denzer, Christian, Wabitsch, Martin

“…Background Rare genetic variations in the leptin-melanocortin signalling pathway can severely impair appetite regulation and cause extreme obesity in early…”
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A fresh look to the phenotype in mono-allelic likely pathogenic variants of the leptin and the leptin receptor gene by Koerber-Rosso, Ingrid, Brandt, Stephanie, von Schnurbein, Julia, Fischer-Posovszky, Pamela, Hoegel, Josef, Rabenstein, Hannah, Siebert, Reiner, Wabitsch, Martin

“…Leptin (LEP) and leptin receptor (LEPR) play a major role in energy homeostasis, metabolism, and reproductive function. While effects of biallelic likely…”
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Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency by Kohlsdorf, Katja, Nunziata, Adriana, Funcke, Jan-Bernd, Brandt, Stephanie, von Schnurbein, Julia, Vollbach, Heike, Lennerz, Belinda, Fritsch, Maria, Greber-Platzer, Susanne, Fröhlich-Reiterer, Elke, Luedeke, Manuel, Borck, Guntram, Debatin, Klaus-Michael, Fischer-Posovszky, Pamela, Wabitsch, Martin

“…Objective: To evaluate whether early childhood body mass index (BMI) is an appropriate indicator for monogenic obesity. Methods: A cohort of n  = 21 children…”
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Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency by Kühnen, Peter, Wabitsch, Martin, von Schnurbein, Julia, Chirila, Costel, Mallya, Usha G, Callahan, Patrick, Gnanasakthy, Ari, Poitou, Christine, Krabusch, Philipp M, Stewart, Murray, Clément, Karine

“…Individuals with proopiomelanocortin (POMC) or leptin receptor (LEPR) deficiency are young and experience severe obesity, hyperphagia, and comorbidities, which…”
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The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges by Haymond, Morey W, Araújo-Vilar, David, Balser, John, Lewis, James H, Louzado, Ruth, Musso, Carla, von Schnurbein, Julia, Wabitsch, Martin

“…Metreleptin, a recombinant analog of human leptin, is an approved therapy, adjunct to diet, to treat the metabolic complications of leptin deficiency in…”
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Lower Circulating Leptin Levels Are Related to Non-Alcoholic Fatty Liver Disease in Children With Obesity by Brandt, Stephanie, von Schnurbein, Julia, Denzer, Christian, Kratzer, Wolfgang, Wabitsch, Martin

“…While for individuals with obesity an association between hyperleptinemia and an increased risk of non-alcoholic fatty liver disease (NAFLD) is assumed, a…”
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First Account of Psychological Changes Perceived by a Female with Congenital Leptin Deficiency upon Treatment with Metreleptin by Hebebrand, Johannes, Zorn, Stefanie, Antel, Jochen, von Schnurbein, Julia, Wabitsch, Martin, Gradl-Dietsch, Gertraud

“…Two psychiatric interviews of a 39-year old female with congenital leptin deficiency were conducted to define psychological changes 14 and 165 days after…”
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Do adolescents with extreme obesity differ according to previous treatment seeking behavior? The Youth with Extreme obesity Study (YES) cohort by Lennerz, Belinda S., Moss, Anja, von Schnurbein, Julia, Bickenbach, Annika, Bollow, Esther, Brandt, Stefanie, Luetke-Brintrup, Diana, Mühlig, Yvonne, Neef, Madlen, Ose, Claudia, Remy, Miriam, Stark, Renee, Teuner, Christina, Wolters, Barbara, Kiess, Wieland, Scherag, André, Reinehr, Thomas, Holl, Reinhard W., Holle, Rolf, Wiegand, Susanna, Hebebrand, Johannes, Wabitsch, Martin

“…Objectives Adolescent extreme obesity is associated with somatic and psychiatric comorbidity, low quality of life, and social dysfunction. Nevertheless, few…”
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