Search Results - "Schnur, R C"

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships by Schnur, R C, Corman, M L, Gallaschun, R J, Cooper, B A, Dee, M F, Doty, J L, Muzzi, M L, DiOrio, C I, Barbacci, E G, Miller, P E

“…Overexpression of the erbB-2 oncogene has been linked to poor prognosis in breast, ovarian, and gastric cancers. Naturally occurring benzoquinoid ansamycin…”
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Binding of benzoquinoid ansamycins to p100 correlates with their ability to deplete the erbB2 gene product p185 by Miller, P, Schnur, R C, Barbacci, E, Moyer, M P, Moyer, J D

“…Several benzoquinoid ansamycins, e.g., herbimycin A and geldanamycin, have been widely used as inhibitors of tyrosine kinases. We recently reported that…”
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Spiro Hydantoin Aldose Reductase Inhibitors by Sarges, Reinhard, Schnur, Rodney C, Belletire, John L, Peterson, Michael J

“…Sorbitol formation from glucose, catalyzed by the enzyme aldose reductase, is believed to play a role in the development of certain chronic complications of…”
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Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives by Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, Moyer, J. D, DiOrio, C. I

“…The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when…”
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In vitro microbiological characterization of novel cyclic homopentapeptides, CP-101,680 and CP-163,234, for animal health use by Norcia, L J, Silvia, A M, Dirlam, J P, Schnur, R C, Bergeron, J M, Retsema, J A, Hayashi, S F

“…Two cyclic homopentapeptides, CP-101,680 and CP-163,234 [6a-(3',4'-dichlorophenylamino) analogs of viomycin and capreomycin, respectively], were identified as…”
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N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide. A novel, systemically active antitumor agent effective against 3LL Lewis Lung carcinoma by Schnur, Rodney C, Fliri, Anton F. J, Kajiji, Shama, Pollack, Vincent A

“…N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxam ide (1) is a member of a series of amides found to substantially increase lifespan in mice bearing…”
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Improved glucose tolerance in rats treated with oxazolidinediones by Schnur, Rodney C, Morville, Malcolm

“…5-(2-Chloro-6-methoxyphenyl)oxazolidine-2,4-dione (49) is the most potent agent selected from a series of 5-substituted oxazolidinediones that were found to…”
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Quantitative structure-activity relationships of antitumor guanidinothiazolecarboxamides with survival enhancement for therapy in the 3LL Lewis lung carcinoma model by Schnur, Rodney C, Gallaschun, Randall J, Singleton, David H, Grissom, Martin, Sloan, Donald E, Goodwin, Peter, McNiff, Patricia A, Fliri, Anton F. J, Mangano, F. Michael

“…Guanidinothiazolecarboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL…”
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Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors by Rizzi, James P, Schnur, Rodney C, Hutson, Nancy J, Kraus, Kenneth G, Kelbaugh, Paul R

“…Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase. Simulation of the rigid spirocyclic ring orientation found in…”
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erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships by Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, DiOrio, C I, Barbacci, E. G

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Tandem [3,3]-Sigmatropic Rearrangements in an Ansamycin: Stereospecific Conversion of an (S)-Allylic Alcohol to an (S)-Allylic Amine Derivative by Schnur, Rodney C, Corman, Michael L

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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity by AN, W. G, SCHNUR, R. C, NECKERS, L, BLAGOSKLONNY, M. V

“…Recently, it has been shown that geldanamycin (GA), a benzoquinone ansamycin, is able to deplete mutant p53, p185erbB2 and Raf-1 proteins in cancer cells…”
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Dehydrations with N-methyl-N,N'-di-tert-butylcarbodiimidium ion by Schnur, R. C, Van Tamelen, E. E

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Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins by MILLER, P, DIORIO, C, MOYER, M, SCHNUR, R. C, BRUSKIN, A, CULLEN, W, MOYER, J. D

“…Herbimycin A, a benzoquinoid ansamycin, is widely used as an inhibitor of tyrosine kinases. We have examined the effects of herbimycin A and several analogues…”
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Synthesis of novel 1,3-oxazino[6,5-b]indole-2,4-(3H,9H)-dione and 2H-1,3,5-oxadiazino[3,2-a]indole-2,4-(3H)-dione from oxindoles by Gallaschun, Randall J., Schnur, Rodney C.

“…Two novel tricyclic ring systems were designed as serine protease inhibitors and synthesized from oxindoles; the first series,…”
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Synthesis of novel 1H-imidazo[5,1-B][3]benzazepine-1,3(2H)-dione and pyrimido[6,1-B][3]benzazepine-1,3,4(2H)-trione by Gallaschun, Randall J., Schnur, Rodney C.

“…Two novel tricyclic ring systems derived from 3‐benzazepines were synthesized; the first, a 6,7,5‐ring, 1H‐imidazo[5,1‐b][3]benzazepine‐1,3(2H)‐dione was…”
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Spiro oxazolidinedione aldose reductase inhibitors by Schnur, Rodney C, Sarges, Reinhard, Peterson, Michael J

“…Spiro oxazolidinediones (2) derived from five- and six-membered ring aralkyl ketones are potent aldose reductase inhibitors in vitro and in vivo. Their novel…”
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Synthesis of 1,2-dihydro-1-oxo-3H-3benzazepine and 3-acyl derivatives by SCHNUR, R. C, GALLASCHUN, R. J

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Inhibition of the oncogene product p185 super(erbB-2) in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives by Schnur, R C, Corman, M L, Gallaschun, R J, Cooper, BA, Dee, M F, Doty, J L, Muzzi, M L, Moyer, J D, DiOrio, C I, Barbacci, E G, Miller, P E, O'Brien, A T, Morin, MJ, Foster, BA, Pollack, V A

“…The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when…”
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Quantitative structure-activity relationships of antitumor guanidinothiazole-carboxamides with survival enhancement for therapy in the 3LL Lewis lung carcinoma model by Schnur, R C, Gallaschun, R J, Singleton, D H, Grissom, M, Sloan, DE, Goodwin, P, McNiff, P A, Fliri, AFJ, Pollack, V A

“…Guanidinothiazole-carboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL…”
Get full text