Search Results - "Schnitzer, Tobias"

Deactivation of Secondary Amine Catalysts via Aldol Reaction-Amine Catalysis under Solvent-Free Conditions by Schnitzer, Tobias, Wennemers, Helma

“…Despite intense interest in amine-catalyzed stereoselective reactions, high catalyst loadings of ≥10 mol % are still common and either due to low reactivity or…”
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Influence of the Trans/Cis Conformer Ratio on the Stereoselectivity of Peptidic Catalysts by Schnitzer, Tobias, Wennemers, Helma

“…Trans/cis isomerization of Xaa-Pro bonds is key for the structure and function of several enzymes. In recent years, numerous versatile peptidic catalysts have…”
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Effect of the enamine pyramidalization direction on the reactivity of secondary amine organocatalysts by Schnitzer, Tobias, Möhler, Jasper S, Wennemers, Helma

“…Chiral secondary amines are valuable catalysts for reactions that proceed through an enamine intermediate. Here, we explored the importance of the…”
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Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT) by Denk, Nora, Maloca, Peter, Steiner, Guido, Freichel, Christian, Bassett, Simon, Schnitzer, Tobias K, Hasler, Pascal W

“…The purpose of this study was to measure central macular thickness in an unprecedented number of cynomolgus monkeys. Macular thickness was measured with…”
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Synthesis of Complex Molecular SystemsThe Foreseen Role of Organic Chemists by Schnitzer, Tobias, Vantomme, Ghislaine

“…How to control the self-assembly of complex molecular systems is unknown. Yet, these complex molecular systems are fundamental for advances in material and…”
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A 3D model to evaluate retinal nerve fiber layer thickness deviations caused by the displacement of optical coherence tomography circular scans in cynomolgus monkeys (Macaca fascicularis) by Niklaus, Stephanie, Hasler, Pascal W, Bryant, Timothy, Desgent, Sebastien, Vezina, Mark, Schnitzer, Tobias K, Maloca, Peter M, Denk, Nora

“…The main objective of the study was to analyze deviations in retinal nerve fiber layer (RNFL) thickness measurements caused by the displacement of circular…”
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Unraveling the Complexity of Supramolecular Copolymerization Dictated by Triazine–Benzene Interactions by Su, Hao, Jansen, Stef A. H, Schnitzer, Tobias, Weyandt, Elisabeth, Rösch, Andreas T, Liu, Jie, Vantomme, Ghislaine, Meijer, E. W

“…Supramolecular copolymers formed by the noncovalent synthesis of multiple components expand the complexity of functional molecular systems. However, varying…”
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In situ Synthesis of Supramolecular Polymers: Finding the Right Conditions when Combining Covalent and Non‐Covalent Synthesis by Schnitzer, Tobias, Jansen, S. A. H., Mabesoone, Mathijs F. J., Vantomme, Ghislaine, Meijer, E. W.

“…The combination of covalent and non‐covalent synthesis is omnipresent in nature and potentially enables access to new materials. Yet, the fundamental…”
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Addition of Organometallic Reagents to Chiral N-Methoxylactams: Enantioselective Syntheses of Pyrrolidines and Piperidines by Jäkel, Mascha, Qu, Jianping, Schnitzer, Tobias, Helmchen, Günter

“…Enantioselective iridium‐catalyzed allylic substitutions were used to prepare N‐allyl hydroxamic acid derivatives that were suitable for ring‐closing…”
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Challenging a Myth and Misconception: Red-Light Vision in Rats by Niklaus, Stephanie, Albertini, Silvio, Schnitzer, Tobias K, Denk, Nora

“…Due to the lack of L-cones in the rodent retina, it is generally assumed that red light is invisible to rodents. Thus, red lights and red filter foils are…”
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Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography by Denk, Nora, Maloca, Peter M, Steiner, Guido, Booler, Helen, Freichel, Christian, Niklaus, Stephanie, Schnitzer, Tobias K, Hasler, Pascal W

“…Cynomolgus macaques are an important and commonly used species in preclinical toxicology studies, but structural reports of in vivo retinal findings are rare…”
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Machine Learning to Develop Peptide CatalystsSuccesses, Limitations, and Opportunities by Schnitzer, Tobias, Schnurr, Martin, Zahrt, Andrew F., Sakhaee, Nader, Denmark, Scott E., Wennemers, Helma

“…Peptides have been established as modular catalysts for various transformations. Still, the vast number of potential amino acid building blocks renders the…”
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Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence by Maloca, Peter M., Müller, Philipp L., Lee, Aaron Y., Tufail, Adnan, Balaskas, Konstantinos, Niklaus, Stephanie, Kaiser, Pascal, Suter, Susanne, Zarranz-Ventura, Javier, Egan, Catherine, Scholl, Hendrik P. N., Schnitzer, Tobias K., Singer, Thomas, Hasler, Pascal W., Denk, Nora

“…Machine learning has greatly facilitated the analysis of medical data, while the internal operations usually remain intransparent. To better comprehend these…”
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Humanely Ending the Life of Animals: Research Priorities to Identify Alternatives to Carbon Dioxide by Steiner, Aline R, Flammer, Shannon Axiak, Beausoleil, Ngaio J, Berg, Charlotte, Bettschart-Wolfensberger, Regula, Pinillos, Rebeca García, Golledge, Huw D W, Marahrens, Michael, Meyer, Robert, Schnitzer, Tobias, Toscano, Michael J, Turner, Patricia V, Weary, Daniel M, Gent, Thomas C

“…The use of carbon dioxide (CO ) for stunning and killing animals is considered to compromise welfare due to air hunger, anxiety, fear, and pain. Despite…”
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Effect of β3‐Amino Acids on the Performance of the Peptidic Catalyst H‐dPro‐Pro‐Glu‐NH2 by Schnitzer, Tobias, Wennemers, Helma

“…The effect of β3‐amino acids on the conformation and catalytic performance of the peptidic catalyst H‐dPro‐Pro‐Glu‐NH2 was investigated. Analogues of the…”
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Effect of β 3 ‐Amino Acids on the Performance of the Peptidic Catalyst H‐ d Pro‐Pro‐Glu‐NH 2 by Schnitzer, Tobias, Wennemers, Helma

“…Abstract The effect of β 3 ‐amino acids on the conformation and catalytic performance of the peptidic catalyst H‐ d Pro‐Pro‐Glu‐NH 2 was investigated…”
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Stereoselective peptide catalysis in complex environments - from river water to cell lysates by Schnitzer, Tobias, Rackl, Jonas W, Wennemers, Helma

“…Many stereoselective peptide catalysts have been established. They consist, like nature's catalysts, of amino acids but have significantly lower molecular…”
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Impact of the β-turn hydrogen bond on the trans/cis ratio and the performance of the peptide catalyst H-dPro-Pro-Glu-NH2 by Schnitzer, Tobias, Ganzoni, Rudolf L., Wennemers, Helma

“…The effect of the β-turn hydrogen bond on the trans/cis conformer ratio and the catalytic performance of the peptidic catalyst H-dPro-Pro-Glu-NH2 was…”
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Peptide–Metal Frameworks with Metal Strings Guided by Dispersion Interactions by Schnitzer, Tobias, Paenurk, Eno, Trapp, Nils, Gershoni-Poranne, Renana, Wennemers, Helma

“…Despite impressive advances in the construction of metal–organic frameworks (MOFs), the formation of networks from peptidic ligands is difficult, though they…”
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Amine Catalysis with Substrates Bearing N‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction by Möhler, Jasper S., Schnitzer, Tobias, Wennemers, Helma

“…Stereoselective organocatalytic C−C bond formations that tolerate N‐heterocycles are valuable since these moieties are common motifs in numerous chiral…”
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