Search Results - "Schnitzer, Thomas"

Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials by Tétreault, Pascal, Mansour, Ali, Vachon-Presseau, Etienne, Schnitzer, Thomas J, Apkarian, A Vania, Baliki, Marwan N

“…Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are…”
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Brain morphological signatures for chronic pain by Baliki, Marwan N, Schnitzer, Thomas J, Bauer, William R, Apkarian, A Vania

“…Chronic pain can be understood not only as an altered functional state, but also as a consequence of neuronal plasticity. Here we use in vivo structural MRI to…”
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Towards a mechanism-based approach to pain management in osteoarthritis by Malfait, Anne-Marie, Schnitzer, Thomas J.

“…Key Points Current evidence supports the idea that osteoarthritis (OA) pain is generated and maintained through continuous nociceptive input from the joint…”
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A Phase II Trial of Lutikizumab, an Anti–Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis by Fleischmann, Roy M., Bliddal, Henning, Blanco, Francisco J., Schnitzer, Thomas J., Peterfy, Charles, Chen, Su, Wang, Li, Feng, Sheng, Conaghan, Philip G., Berenbaum, Francis, Pelletier, Jean‐Pierre, Martel‐Pelletier, Johanne, Vaeterlein, Ole, Kaeley, Gurjit S., Liu, Wei, Kosloski, Matthew P., Levy, Gwen, Zhang, Lanju, Medema, Jeroen K., Levesque, Marc C.

“…Objective To assess the efficacy and safety of the anti–interleukin‐1α/β (anti–IL‐1α/β) dual variable domain immunoglobulin lutikizumab (ABT‐981) in patients…”
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The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis by Smith, Toby O, Hawker, Gillian A, Hunter, David J, March, Lyn M, Boers, Maarten, Shea, Beverley J, Christensen, Robin, Guillemin, Francis, Terwee, Caroline B, Williamson, Paula R, Dodd, Susanna, Roos, Ewa M, Loeser, Richard F, Schnitzer, Thomas J, Kloppenburg, Margreet, Neogi, Tuhina, Ladel, Christoph H, Kalsi, Gurdyal, Kaiser, Ulrike, Buttel, Thomas W, Ashford, Anne E, Mobasheri, Ali, Arden, Nigel K, Tennant, Alan, Hochberg, Marc C, de Wit, Maarten, Tugwell, Peter, Conaghan, Philip G

“…To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip…”
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Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial by Schnitzer, Thomas J, Easton, Richard, Pang, Shirley, Levinson, Dennis J, Pixton, Glenn, Viktrup, Lars, Davignon, Isabelle, Brown, Mark T, West, Christine R, Verburg, Kenneth M

“…IMPORTANCE: Patients with osteoarthritis (OA) may remain symptomatic with traditional OA treatments. OBJECTIVE: To assess 2 subcutaneous tanezumab dosing…”
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Corticostriatal functional connectivity predicts transition to chronic back pain by Baliki, Marwan N, Petre, Bogdan, Torbey, Souraya, Herrmann, Kristina M, Huang, Lejian, Schnitzer, Thomas J, Fields, Howard L, Apkarian, A Vania

“…In a longitudinal brain imaging study, patients with subacute back pain were followed over the course of 1 year. Initially greater functional connectivity of…”
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Corticolimbic anatomical characteristics predetermine risk for chronic pain by Vachon-Presseau, Etienne, Tétreault, Pascal, Petre, Bogdan, Huang, Lejian, Berger, Sara E, Torbey, Souraya, Baria, Alexis T, Mansour, Ali R, Hashmi, Javeria A, Griffith, James W, Comasco, Erika, Schnitzer, Thomas J, Baliki, Marwan N, Apkarian, A Vania

“…SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties…”
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Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits by HASHMI, Javeria A, BALIKI, Marwan N, LEJIAN HUANG, BARIA, Alex T, TORBEY, Souraya, HERMANN, Kristina M, SCHNITZER, Thomas J, APKARIAN, A. Vania

“…Chronic pain conditions are associated with abnormalities in brain structure and function. Moreover, some studies indicate that brain activity related to the…”
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Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee by Lane, Nancy E, Schnitzer, Thomas J, Birbara, Charles A, Mokhtarani, Masoud, Shelton, David L, Smith, Mike D, Brown, Mark T

“…Modeling studies show that increased expression of nerve growth factor is associated with increased pain. This study tested the safety and efficacy of the…”
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Reorganization of functional brain network architecture in chronic osteoarthritis pain by Barroso, Joana, Wakaizumi, Kenta, Reis, Ana Mafalda, Baliki, Marwan, Schnitzer, Thomas J., Galhardo, Vasco, Apkarian, Apkar Vania

“…Osteoarthritis (OA) manifests with chronic pain, motor impairment, and proprioceptive changes. However, the role of the brain in the disease is largely…”
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Identification of traits and functional connectivity-based neurotraits of chronic pain by Vachon-Presseau, Etienne, Berger, Sara E, Abdullah, Taha B, Griffith, James W, Schnitzer, Thomas J, Apkarian, A Vania

“…Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied…”
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Brain white matter structural properties predict transition to chronic pain by Mansour, Ali R., Baliki, Marwan N., Huang, Lejian, Torbey, Souraya, Herrmann, Kristi M., Schnitzer, Thomas J., Apkarian, A. Vania

“…White matter fractional anisotropy differences accurately predicted back pain persistence over 1year, and showed minimal alterations over the 1-year period…”
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Brain gray matter abnormalities in osteoarthritis pain: a cross-sectional evaluation by Barroso, Joana, Vigotsky, Andrew D., Branco, Paulo, Reis, Ana Mafalda, Schnitzer, Thomas J., Galhardo, Vasco, Apkarian, A. Vania

“…The interaction between osteoarthritis (OA) pain and brain properties remains minimally understood, although anatomical and functional neuroimaging studies…”
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Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain by Reckziegel, Diane, Vachon-Presseau, Etienne, Petre, Bogdan, Schnitzer, Thomas J., Baliki, Marwan N., Apkarian, A. Vania

“…This review expounds on types and properties of biomarkers for chronic pain, given a mechanistic model of processes underlying development of chronic pain. It…”
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The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial by Dakin, Paula, DiMartino, Stephen J., Gao, Haitao, Maloney, Jennifer, Kivitz, Alan J., Schnitzer, Thomas J., Stahl, Neil, Yancopoulos, George D., Geba, Gregory P.

“…Objective To prospectively assess the efficacy, general safety, and joint safety of fasinumab, an anti–nerve growth factor monoclonal antibody, in…”
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Clopidogrel with or without Omeprazole in Coronary Artery Disease by Bhatt, Deepak L, Cryer, Byron L, Contant, Charles F, Cohen, Marc, Lanas, Angel, Schnitzer, Thomas J, Shook, Thomas L, Lapuerta, Pablo, Goldsmith, Mark A, Laine, Loren, Scirica, Benjamin M, Murphy, Sabina A, Cannon, Christopher P

“…In patients receiving dual antiplatelet therapy, omeprazole reduced the risk of upper-GI toxic effects but did not increase the risk of cardiovascular events;…”
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Brain and psychological determinants of placebo pill response in chronic pain patients by Vachon-Presseau, Etienne, Berger, Sara E., Abdullah, Taha B., Huang, Lejian, Cecchi, Guillermo A., Griffith, James W., Schnitzer, Thomas J., Apkarian, A. Vania

“…The placebo response is universally observed in clinical trials of pain treatments, yet the individual characteristics rendering a patient a ‘placebo…”
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WOMAC Meaningful Within-patient Change: Results From 3 Studies of Tanezumab in Patients With Moderate-to-severe Osteoarthritis of the Hip or Knee by Conaghan, Philip G, Dworkin, Robert H, Schnitzer, Thomas J, Berenbaum, Francis, Bushmakin, Andrew G, Cappelleri, Joseph C, Viktrup, Lars, Abraham, Lucy

“…To define meaningful within-patient change (MWPC) in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Data were analyzed separately…”
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Long‐Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial by Hochberg, Marc C., Carrino, John A., Schnitzer, Thomas J., Guermazi, Ali, Walsh, David A., White, Alexander, Nakajo, Satoru, Fountaine, Robert J., Hickman, Anne, Pixton, Glenn, Viktrup, Lars, Brown, Mark T., West, Christine R., Verburg, Kenneth M.

“…Objective To assess the long‐term safety and 16‐week efficacy of subcutaneous tanezumab in patients with hip or knee osteoarthritis (OA). Methods This was a…”
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