Search Results - "Schnittman, SM"

Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: Implications for antiviral therapy by Pantaleo, Giuseppe, Cohen, Oren J, Schacker, Timothy, Vaccarezza, Mauro, Graziosi, Cecilia, Rizzardi, G. Paolo, Kahn, James, Fox, Cecil H, Schnittman, Steven M, Schwartz, David H, Corey, Lawrence, Fauci, Anthony S

“…Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node…”
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Lymphoid Organs Function as Major Reservoirs for Human Immunodeficiency Virus by Pantaleo, Giuseppe, Graziosi, Cecilia, Butini, Luca, Pizzo, Philip A., Schnittman, Steven M., Kotler, Donald P., Fauci, Anthony S.

“…The total number of human immunodeficiency virus type 1 (HIV-1)-infected circulating CD4+T lymphocytes is considered to be a reflection of the HIV burden at…”
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The Reservoir for HIV-1 in Human Peripheral Blood is a T Cell that Maintains Expression of CD4 by Schnittman, Steven M., Psallidopoulos, Miltiades C., Lane, H. Clifford, Thompson, Louis, Baseler, Michael, Massari, Ferdinand, Fox, Cecil H., Salzman, Norman P., Fauci, Anthony S.

“…Human immunodeficiency virus type 1 (HIV-1) selectively infects cells expressing the CD4 molecule, resulting in substantial quantitative and qualitative…”
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Preferential Infection of CD4+Memory T Cells by Human Immunodeficiency Virus Type 1: Evidence for a Role in the Selective T-Cell Functional Defects Observed in Infected Individuals by Schnittman, Steven M., Lane, H. Clifford, Greenhouse, Jack, Justement, Jesse S., Baseler, Michael, Fauci, Anthony S.

“…CD4+T cells of patients with AIDS exhibit a qualitative defect in their ability to respond to soluble antigen while their responses to mitogens remain normal…”
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Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease by Schnittman, S M, Greenhouse, J J, Psallidopoulos, M C, Baseler, M, Salzman, N P, Fauci, A S, Lane, H C

“…To determine over time the relation between viral burden and immunologic decline in patients with asymptomatic human immunodeficiency virus (HIV) infection…”
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Primary Human Immunodeficiency Virus Type 1 Infection: Review of Pathogenesis and Early Treatment Intervention in Humans and Animal Retrovirus Infections by Niu, Manette T., Stein, Daniel S., Schnittman, Steven M.

“…Primary human immunodeficiency virus type 1 (HIV-1) infection can present clinically as the abrupt onset of a febrile illness resembling acute mononucleosis…”
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CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals by Stanley, SK, Kessler, SW, Justement, JS, Schnittman, SM, Greenhouse, JJ, Brown, CC, Musongela, L, Musey, K, Kapita, B, Fauci, AS

“…Individuals infected with HIV frequently develop cytopenias and suppressed hematopoiesis. The role of direct HIV infection of hematopoietic progenitor cells in…”
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BMS-790052, A NS5A REPLICATION COMPLEX INHIBITOR, COMBINED WITH PEGINTERFERON ALFA-2A AND RIBIVIRIN IN TREATMENT-NAIVE HCV-GENO-TYPE 1 OR 4 PATIENTS: PHASE 2B AI444010 STUDY INTERIM WEEK 12 RESULTS by Hezode, C, Hirschfield, GM, Ghesquiere, W, Sievert, W, Rodriguez-Torres, M, Shafran, SD, Thuluvath, PJ, Tatum, HA, Waked, I, Esmat, GE, Lawitz, E, Rustgi, VK, Pol, S, Weis, N, Pockros, P, Bourliere, M, Serfaty, L, Vierling, JM, Fried, MW, Weiland, O, Brunetto, MR, Everson, GT, Zeuzem, S, Kwo, PY, Sulkowski, MS, Yin, PD, Diva, UA, Hughes, EA, Wind-Rotolo, M, Schnittman, SM

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Zidovudine Treatment in Patients with Primary (Acute) Human Immunodeficiency Virus Type 1 Infection: A Randomized, Double-Blind, Placebo-Controlled Trial by Niu, Manette T., Bethel, James, Holodniy, Mark, Standiford, Harold C., Schnittman, Steven M.

“…A multicenter, double-blind, placebo-controlled trial randomized 28 patients with primary (acute) human immunodeficiency virus (HIV)-1 infection (PHI) to…”
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Preliminary evidence for partial restoration of immune function in HIV type 1 infection with potent antiretroviral therapies: clues from the Fourth Conference on Retroviruses and Opportunistic Diseases by Schnittman, S M, Fox, L

“…Critical advances in understanding the pathogenesis and treatment of HIV-1 infection have been made. These include the following: delineation of the…”
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Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion by Schnittman, S M, Denning, S M, Greenhouse, J J, Justement, J S, Baseler, M, Kurtzberg, J, Haynes, B F, Fauci, A S

“…Individuals infected by the human immunodeficiency virus type 1 (HIV-1) demonstrate progressive depletion and qualitative dysfunction of the helper T4 (CD4+)…”
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Direct Polyclonal activation of human b lymphocytes by the acquired immune deficiency syndrome virus by Schnittman, Steven M., Lane, H. Clifford, Higgins, Sandra E., Folks, Thomas, Fauci, Anthony S.

“…When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS),…”
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Integrated proviral human immunodeficiency virus type 1 is present in CD4+ peripheral blood lymphocytes in healthy seropositive individuals by PSALLIDOPOULOS, M. C, SCHNITTMAN, S. M, THOMPSON, L. M. III, BASELER, M, FAUCI, A. S, LANE, H. C, SALZMAN, N. P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A phase I study of interferon-alpha 2b in combination with interleukin-2 in patients with human immunodeficiency virus infection by Schnittman, S M, Vogel, S, Baseler, M, Lane, H C, Davey, Jr, R T

“…Interferon-alpha (IFN-alpha) can inhibit human immunodeficiency virus (HIV-1) replication and is effective in treating Kaposi's sarcoma; interleukin-2 (IL-2)…”
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Potential Role of Lamivudine (3TC) in the Clearance of Chronic Hepatitis B Virus Infection in a Patient Coinfected with Human Immunodeficiency Virus Type 1 by Schnittman, Steven M., Pierce, Phillip F.

“…A 35-year-old male homosexual with known HIV-1 infection since 1984 was referred to the Georgetown University HIV clinic (Washington, D.C.) in January 1994. At…”
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Emergence of Unusual Opportunistic Pathogens in AIDS: A Review by Gradon, Jeremy D., Timpone, Joseph G., Schnittman, Steven M.

“…Opportunistic infections are a major cause of morbidity and death among patients infected with the human immunodeficiency virus (HIV), particularly late in the…”
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CD8+ cytolytic T lymphocytes become infected in vitro in the process of killing HIV-1-infected target cells by De Maria, A, Colombini, S, Schnittman, S M, Moretta, L

“…In the present study the requirements for in vitro infection of antigen-specific CD8+ cytotoxic T lymphocytes (CTL) with human immunodeficiency virus -1(HIV-1)…”
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Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease by Kalter, DC, Greenhouse, JJ, Orenstein, JM, Schnittman, SM, Gendelman, HE, Meltzer, MS

“…Several reports implicate Langerhans cells of skin as susceptible targets, reservoirs, and vectors for transmission of HIV: 1) numbers of Langerhans cells in…”
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Experience with a cross-study endpoint review committee for AIDS clinical trials by GREEN, L. A, RHAME, F. S, KRUM, E. A, NEATON, J. D, PRICE, R. W, PERLMAN, D. C, CAPPS, L. G, SAMPSON, J. H, DEYTON, L. R, SCHNITTMAN, S. M, FISHER, E. J, BARTSCH, G. E

“…To describe the methods and results of a standardized system for clinical endpoint determination for defining and reviewing endpoints in clinical trials for…”
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Infection of CD8+ T lymphocytes with HIV. Requirement for interaction with infected CD4+ cells and induction of infectious virus from chronically infected CD8+ cells by De Maria, A, Pantaleo, G, Schnittman, SM, Greenhouse, JJ, Baseler, M, Orenstein, JM, Fauci, AS

“…In this study, we have investigated the basic requirements for HIV-1 infection of CD8+ lymphocytes in vitro. Unfractionated PBL obtained from healthy HIV-1…”
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