Search Results - "Schnier, Paul"

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling by Noland, Cameron L., Gierke, Sarah, Schnier, Paul D., Murray, Jeremy, Sandoval, Wendy N., Sagolla, Meredith, Dey, Anwesha, Hannoush, Rami N., Fairbrother, Wayne J., Cunningham, Christian N.

“…The Hippo signaling pathway is responsible for regulating the function of TEAD family transcription factors in metazoans. TEADs, with their co-activators…”
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Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry by Yang, Bing, Wu, Haifan, Schnier, Paul D., Liu, Yansheng, Liu, Jun, Wang, Nanxi, DeGrado, William F., Wang, Lei

“…Chemical cross-linking mass spectrometry (CXMS) is being increasingly used to study protein assemblies and complex protein interaction networks. Existing CXMS…”
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Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins by Yang, Bing, Wang, Nanxi, Schnier, Paul D, Zheng, Feng, Zhu, He, Polizzi, Nicholas F, Ittuveetil, Avinash, Saikam, Varma, DeGrado, William F, Wang, Qian, Wang, Peng G, Wang, Lei

“…Expansion of the genetic code with unnatural amino acids (Uaas) has significantly increased the chemical space available to proteins for exploitation. Due to…”
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Reliable Determinations of Protein–Ligand Interactions by Direct ESI-MS Measurements. Are We There Yet? by Kitova, Elena N., El-Hawiet, Amr, Schnier, Paul D., Klassen, John S.

“…The association-dissociation of noncovalent interactions between protein and ligands, such as other proteins, carbohydrates, lipids, DNA, or small molecules,…”
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On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods by Poppe, Leszek, Jordan, John B, Rogers, Gary, Schnier, Paul D

“…An important aspect in the analytical characterization of protein therapeutics is the comprehensive characterization of higher order structure (HOS). Nuclear…”
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Fibril treatment changes protein interactions of tau and α-synuclein in human neurons by Griffin, Tagan A., Schnier, Paul D., Cleveland, Elisa M., Newberry, Robert W., Becker, Julia, Carlson, George A.

“…In several neurodegenerative disorders, the neuronal proteins tau and α-synuclein adopt aggregation-prone conformations capable of replicating within and…”
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Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure by Jordan, John B., Poppe, Leszek, Haniu, Mitsuru, Arvedson, Tara, Syed, Rashid, Li, Vivian, Kohno, Hiko, Kim, Helen, Schnier, Paul D., Harvey, Timothy S., Miranda, Les P., Cheetham, Janet, Sasu, Barbra J.

“…Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which has been shown to act as the principal regulator of iron…”
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Resolving Disulfide Structural Isoforms of IgG2 Monoclonal Antibodies by Ion Mobility Mass Spectrometry by Bagal, Dhanashri, Valliere-Douglass, John F., Balland, Alain, Schnier, Paul D.

“…Recombinant monoclonal antibodies are an important class of therapeutic agents that have found widespread use for the treatment of many human diseases. Here,…”
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Profiling formulated monoclonal antibodies by (1)H NMR spectroscopy by Poppe, Leszek, Jordan, John B, Lawson, Ken, Jerums, Matthew, Apostol, Izydor, Schnier, Paul D

“…Nuclear magnetic resonance (NMR) is arguably the most direct methodology for characterizing the higher-order structure of proteins in solution. Structural…”
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Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates by Bagal, Dhanashri, Zhang, Heidi, Schnier, Paul D

“…Gas-phase ion/molecule chemistry has been combined with ion mobility separation and time-of-flight mass spectrometry to enable the characterization of large…”
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Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance by Campuzano, Iain D. G, Li, Huilin, Bagal, Dhanashri, Lippens, Jennifer L, Svitel, Juraj, Kurzeja, Robert J. M, Xu, Han, Schnier, Paul D, Loo, Joseph A

“…Over the past two decades, orthogonal acceleration time-of-flight has been the de facto analyzer for solution and membrane-soluble protein native mass…”
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Hydrophobic Protein−Ligand Interactions Preserved in the Gas Phase by Liu, Lan, Bagal, Dhanashri, Kitova, Elena N., Schnier, Paul D., Klassen, John S.

“…The results of time-resolved thermal dissociation measurements and molecular dynamic simulations are reported for gaseous deprotonated ions of the specific…”
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Ordering of the N‑Terminus of Human MDM2 by Small Molecule Inhibitors by Michelsen, Klaus, Jordan, John B, Lewis, Jeffrey, Long, Alexander M, Yang, Evelyn, Rew, Yosup, Zhou, Jing, Yakowec, Peter, Schnier, Paul D, Huang, Xin, Poppe, Leszek

“…Restoration of p53 function through the disruption of the MDM2-p53 protein complex is a promising strategy for the treatment of various types of cancer. Here,…”
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Structural and Functional Analysis of the Native Peripherin-ROM1 Complex Isolated from Photoreceptor Cells by Kevany, Brian M., Tsybovsky, Yaroslav, Campuzano, Iain D.G., Schnier, Paul D., Engel, Andreas, Palczewski, Krzysztof

“…Peripherin and its homologue ROM1 are retina-specific members of the tetraspanin family of integral membrane proteins required for morphogenesis and…”
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Energetics of Lipid Binding in a Hydrophobic Protein Cavity by Liu, Lan, Michelsen, Klaus, Kitova, Elena N, Schnier, Paul D, Klassen, John S

“…Hydrophobic bonding is central to many biochemical processes, such as protein folding and association. However, a complete description of the forces underlying…”
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Reduced Amino Acid Specificity of Mammalian Tyrosyl-tRNA Synthetase Is Associated with Elevated Mistranslation of Tyr Codons by Raina, Medha, Moghal, Adil, Kano, Amanda, Jerums, Mathew, Schnier, Paul D., Luo, Shun, Deshpande, Rohini, Bondarenko, Pavel V., Lin, Henry, Ibba, Michael

“…Quality control operates at different steps in translation to limit errors to approximately one mistranslated codon per 10,000 codons during mRNA-directed…”
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Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods by Poppe, Leszek, Jordan, John B, Rogers, Gary, Schnier, Paul D

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PADLOC: A Powerful Tool to Assign Disulfide Bond Connectivities in Peptides and Proteins by NMR Spectroscopy by Poppe, Leszek, Hui, John O, Ligutti, Joseph, Murray, Justin K, Schnier, Paul D

“…The determination of the disulfide bond connectivity in a peptide or protein represents a significant challenge. It is notoriously difficult to use NMR…”
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Gas Phase Stabilization of Noncovalent Protein Complexes Formed by Electrospray Ionization by Bagal, Dhanashri, Kitova, Elena N, Liu, Lan, El-Hawiet, Amr, Schnier, Paul D, Klassen, John S

“…The use of gas phase additives to stabilize noncovalent protein complexes in electrospray ionization mass spectrometry (ES-MS) is demonstrated for two…”
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Evidence that Water Can Reduce the Kinetic Stability of Protein−Hydrophobic Ligand Interactions by Liu, Lan, Michelsen, Klaus, Kitova, Elena N, Schnier, Paul D, Klassen, John S

“…The first quantitative comparison of the thermal dissociation rate constants measured for protein−ligand complexes in their hydrated and dehydrated states is…”
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