Search Results - "Schneider, Tanya L."

Application of H/D Exchange to Hydrogen Bonding in Small Molecules by Schneider, Tanya L., Halloran, Kevin T., Hillner, Julie A., Conry, Rebecca R., Linton, Brian R.

“…Do you recognize me? A series of simple amides has been used to demonstrate the application of hydrogen/deuterium exchange in small‐molecule hydrogen bonding…”
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Oxidase Domains in Epothilone and Bleomycin Biosynthesis:  Thiazoline to Thiazole Oxidation during Chain Elongation by Schneider, Tanya L, Shen, Ben, Walsh, Christopher T

“…The natural products epothilone and bleomycin are assembled by hybrid polyketide/nonribosomal peptide synthetases. Of note in these assembly lines is the…”
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Increasing the Kinase Specificity of K252a by Protein Surface Recognition by Schneider, Tanya L, Mathew, Rebecca S, Rice, Kevin P, Tamaki, Kazuhiko, Wood, John L, Schepartz, Alanna

“…Here we describe a miniature protein (1) that presents the cAMP-dependent protein kinase (PKA) recognition epitope found within the heat-stable Protein Kinase…”
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Why Are Gly31, Gly33, and Gly35 Highly Conserved in All Fluorescent Proteins? by Nwafor, Justin, Salguero, Christian, Welcome, Franceine, Durmus, Sercan, Glasser, Rachel N, Zimmer, Marc, Schneider, Tanya L

“…Green fluorescent protein (GFP)-like fluorescent proteins have been found in more than 120 species. Although the proteins have little sequence identity, Gly31,…”
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Epothilone C Macrolactonization and Hydrolysis Are Catalyzed by the Isolated Thioesterase Domain of Epothilone Polyketide Synthase by Boddy, Christopher N, Schneider, Tanya L, Hotta, Kinya, Walsh, Christopher T, Khosla, Chaitan

“…Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme…”
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Molecular Insights into the Impact of Oxidative Stress on the Quorum-Sensing Regulator Protein LasR by Kafle, Prapti, Amoh, Amanda N., Reaves, Jocelyn M., Suneby, Emma G., Tutunjian, Kathryn A., Tyson, Reed L., Schneider, Tanya L.

“…The LasR regulator protein functions at the top of the Pseudomonas aeruginosa quorum-sensing hierarchy and is implicated in promoting bacterial virulence. Of…”
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Unusual non-enzymatic flavin catalysis enhances understanding of flavoenzymes by Argueta, Erick A., Amoh, Amanda N., Kafle, Prapti, Schneider, Tanya L.

“…•Naturally occurring flavins can act as stand-alone catalysts in aqueous buffer.•Both flavins and flavoprotein oxidases catalyze the oxidation of thiazoline…”
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Pseudomonas aeruginosa LasR·DNA Binding Is Directly Inhibited by Quorum Sensing Antagonists by Suneby, Emma G, Herndon, Leslie R, Schneider, Tanya L

“…Inhibition of quorum sensing in Pseudomonas aeruginosa is of interest as a possible antivirulence strategy for this pathogenic bacterium. The LasR regulator…”
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Discovering Chemical Aromaticity Using Fragrant Plants by Schneider, Tanya L

“…Introductory organic chemistry is often perceived as inaccessible by students. This article describes a method used to link organic chemistry to everyday…”
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Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits by WALSH, Christopher T, O'CONNOR, Sarah E, SCHNEIDER, Tanya L

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Portability of Oxidase Domains in Nonribosomal Peptide Synthetase Modules by Schneider, Tanya L, Walsh, Christopher T

“…Oxazole and thiazole rings are present in numerous nonribosomal peptide natural products. Oxidase domains are responsible for catalyzing the oxidation of…”
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Introduction to Protein Structure through Genetic Diseases by Schneider, Tanya L, Linton, Brian R

“…An illuminating way to learn about protein function is to explore high-resolution protein structures. Analysis of the proteins involved in genetic diseases has…”
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DNA Specificity Enhanced by Sequential Binding of Protein Monomers by Kohler, Jennifer J., Metallo, Steven J., Schneider, Tanya L., Schepartz, Alanna

“…Transcriptional activation often requires the rapid assembly of complexes between dimeric transcription factors and specific DNA sites. Here we show that…”
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Utilization of Alternate Substrates by the First Three Modules of the Epothilone Synthetase Assembly Line by Schneider, Tanya L, Walsh, Christopher T, O'Connor, Sarah E

“…The epothilones, a family of macrolactone natural products produced by the myxobacterial species Sorangium cellulosum, are of current clinical interest as…”
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Hepatitis B Virus Protein pX Enhances the Monomer Assembly Pathway of bZIP·DNA Complexes by Schneider, Tanya L, Schepartz, Alanna

“…The rapid and correct assembly of dimeric transcription factors on target DNA is essential for accurate transcriptional regulation. Here we ask how a viral…”
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Hepatitis B Virus X Protein Activates Transcription by Bypassing CREB Phosphorylation, Not by Stabilizing bZIP−DNA Complexes by Pflum, Mary Kay H, Schneider, Tanya L, Hall, David, Schepartz, Alanna

“…Although previous work has shown that the hepatitis B virus X protein (pX) stabilizes complexes between basic region leucine zipper (bZIP) proteins and target…”
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Toxicarioside B and toxicarioside C. New cardenolides isolated from Antiaris toxicaria latex-derived dart poison by Carter, Christine A., Gray, Elizabeth A., Schneider, Tanya L., Lovett, Charles M., Scott, Lincoln, Messer, Adam C., Richardson, David P.

“…Bioassay-guided fractionation of the chloroform/methanol extract of a dart poison from Indonesian Borneo (Kalimantan), derived from Antiaris toxicaria latex,…”
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Toxicarioside A. A new cardenolide isolated from Antiaris toxicaria latex-derived dart poison. Assignment of the 1H- and 13C-NMR shifts for an antiarigenin aglycone by Carter, Christine A., Forney, Robert W., Gray, Elizabeth A., Gehring, Amy M., Schneider, Tanya L., Young, David B., Lovett, Charles M., Scott, Lincoln, Messer, Adam C., Richardson, David P.

“…Bioassay-guided fractionation of the chloroform/methanol extract of a dart poison from Indonesian Borneo (Kalimantan), derived from Antiaris toxicaria latex,…”
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Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits by Walsh, Christopher T, O'Connor, Sarah E, Schneider, Tanya L

“…The epothilones are a family of macrolactone natural products from the myxobacterial species Sorangium cellulosum. Similar to taxol, they are of current…”
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