Search Results - "Schneider, Paula"

Evidence of Conformational Changes in the Structure of Y‐Family Human Polymerase Kappa by Schneider, Paula L. C., Sampoli Benitez, Benedetta

“…Y‐family DNA polymerases, unlike replicative DNA polymerases, are enzymes characterized by their ability to bypass DNA lesions and continue extension of…”
Get full text

A molecular phylogeny of living primates by Perelman, Polina, Johnson, Warren E, Roos, Christian, Seuánez, Hector N, Horvath, Julie E, Moreira, Miguel A M, Kessing, Bailey, Pontius, Joan, Roelke, Melody, Rumpler, Yves, Schneider, Maria Paula C, Silva, Artur, O'Brien, Stephen J, Pecon-Slattery, Jill

“…Comparative genomic analyses of primates offer considerable potential to define and understand the processes that mold, shape, and transform the human genome…”
Get full text

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization by Dai, Haiming, Smith, Alyson, Meng, X Wei, Schneider, Paula A, Pang, Yuan-Ping, Kaufmann, Scott H

“…The mechanism by which the proapoptotic Bcl-2 family members Bax and Bak release cytochrome c from mitochondria is incompletely understood. In this paper, we…”
Get full text

A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia by Murthy, Guru Subramanian Guru, Saliba, Antoine N, Szabo, Aniko, Harrington, Alexandra, Abedin, Sameem, Carlson, Karen, Michaelis, Laura, Runaas, Lyndsey, Baim, Arielle, Hinman, Alex, Maldonado-Schmidt, Sonia, Venkatachalam, Annapoorna, Flatten, Karen S, Peterson, Kevin L, Schneider, Paula A, Litzow, Mark, Kaufmann, Scott H, Atallah, Ehab

“…Azacitidine/venetoclax is an active regimen in patients with newly diagnosed acute myeloid leukemia (AML). However, primary or secondary resistance to…”
Get full text

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells by Schroeder, Barbara, Vander Steen, Travis, Espinoza, Ingrid, Venkatapoorna, Chandra M. Kurapaty, Hu, Zeng, Silva, Fernando Martín, Regan, Kevin, Cuyàs, Elisabet, Meng, X. Wei, Verdura, Sara, Arbusà, Aina, Schneider, Paula A., Flatten, Karen S., Kemble, George, Montero, Joan, Kaufmann, Scott H., Menendez, Javier A., Lupu, Ruth

“…Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However,…”
Get full text

Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance by HAIMING DAI, HUSHENG DING, WEI MENG, X, LEE, Sun-Hee, SCHNEIDER, Paula A, KAUFMANN, Scott H

“…Bcl-2 is phosphorylated on Ser(70) after treatment of cells with spindle poisons. On the basis of effects observed in cells overexpressing Bcl-2 S70E or S70A…”
Get full text

BioPipeline Creator—a user-friendly Java-based GUI for managing and customizing biological data pipelines by Maia Cordeiro, Cléo, da Silva Moia, Gislenne, de Oliveira, Mônica Silva, da Silva e Silva, Lucas, Cruz Schneider, Maria Paula, Costa, Sávio S., Baraúna, Rafael Azevedo, das Graças, Diego Assis, Silva, Artur, de Oliveira Veras, Adonney Allan

“…Bioinformatics tools are essential for performing analyses in the omics sciences. Given the numerous experimental opportunities arising from advances in the…”
Get full text

Immunodetection of human topoisomerase I-DNA covalent complexes by Patel, Anand G, Flatten, Karen S, Peterson, Kevin L, Beito, Thomas G, Schneider, Paula A, Perkins, Angela L, Harki, Daniel A, Kaufmann, Scott H

“…A number of established and investigational anticancer drugs slow the religation step of DNA topoisomerase I (topo I). These agents induce cytotoxicity by…”
Get full text

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells by Dai, Haiming, Ding, Husheng, Meng, X Wei, Peterson, Kevin L, Schneider, Paula A, Karp, Judith E, Kaufmann, Scott H

“…Mitochondrial outer membrane permeabilization (MOMP), a key step in the intrinsic apoptotic pathway, is incompletely understood. Current models emphasize the…”
Get full text

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes by Patel, Anand G., Flatten, Karen S., Schneider, Paula A., Dai, Nga T., McDonald, Jennifer S., Poirier, Guy G., Kaufmann, Scott H.

“…Poly(ADP-ribose) polymerase-1 (PARP1) plays critical roles in the regulation of DNA repair. Accordingly, small molecule inhibitors of PARP are being developed…”
Get full text

BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma by Correia, Cristina, Schneider, Paula A., Dai, Haiming, Dogan, Ahmet, Maurer, Matthew J., Church, Amy K., Novak, Anne J., Feldman, Andrew L., Wu, Xiaosheng, Ding, Husheng, Meng, X. Wei, Cerhan, James R., Slager, Susan L., Macon, William R., Habermann, Thomas M., Karp, Judith E., Gore, Steven D., Kay, Neil E., Jelinek, Diane F., Witzig, Thomas E., Nowakowski, Grzegorz S., Kaufmann, Scott H.

“…Follicular lymphoma (FL), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene and immunoglobulin locus, has a…”
Get full text

A Predictive Investigation of Reputation as Mediator of the Political-Skill/Career-Success Relationship by BLICKLE, GERHARD, SCHNEIDER, PAULA B., LIU, YONGMEI, FERRIS, GERALD R.

“…Career success is determined by a number of factors, including some combination of specific competencies and a performance record, along with network…”
Get full text

Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors by Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L, Hou, Xianon, Schneider, Paula A, Strathman, Annabella R, Flatten, Karen S, Sine, Chance C, Balczewski, Emily A, McGehee, Cordelia D, Larson, Melissa C, Duffield, Laura N, Meng, X Wei, Vincelette, Nicole D, Ding, Husheng, Oberg, Ann L, Couch, Fergus J, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid…”
Get full text

AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death by Jia, Jia, Ji, Wenbo, Saliba, Antoine N., Csizmar, Clifford M., Ye, Kaiqin, Hu, Lei, Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Venkatachalam, Annapoorna, Patnaik, Mrinal M., Webster, Jonathan A., Smith, B. Douglas, Ghiaur, Gabriel, Wu, Xinyan, Zhong, Jun, Pandey, Akhilesh, Flatten, Karen S., Deng, Qingmei, Wang, Hongzhi, Kaufmann, Scott H., Dai, Haiming

“…BH3 mimetics, including the BCL2/BCLX L /BCLw inhibitor navitoclax and MCL1 inhibitors S64315 and tapotoclax, have undergone clinical testing for a variety of…”
Get full text

Measurement of BH3-only protein tolerance by Dai, Haiming, Ding, Husheng, Peterson, Kevin L, Meng, X Wei, Schneider, Paula A, Knorr, Katherine L B, Kaufmann, Scott H

“…The BCL2 family of proteins regulates cellular life and death decisions. Among BCL2 family members, BH3-only proteins have critical roles by neutralizing…”
Get full text

Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era by Correia, Cristina, Maurer, Matthew J., McDonough, Samantha J., Schneider, Paula A., Ross, Paige E., Novak, Anne J., Feldman, Andrew L., Cerhan, James R., Slager, Susan L., Witzig, Thomas E., Eckloff, Bruce W., Li, Hu, Nowakowski, Grzegorz S., Kaufmann, Scott H.

“…How to identify follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. Building on a prior study…”
Get full text

Self-initiated mentoring and career success: A predictive field study by Blickle, Gerhard, Witzki, Alexander, Schneider, Paula B.

“…There is a growing recognition of the proactive role of individuals in the world of work. Therefore, the roles of self-initiated mentoring and networking…”
Get full text

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies by Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.

“…The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which…”
Get full text

Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression by Meng, X.Wei, Koh, Brian D., Zhang, Jin-San, Flatten, Karen S., Schneider, Paula A., Billadeau, Daniel D., Hess, Allan D., Smith, B.Douglas, Karp, Judith E., Kaufmann, Scott H.

“…Recombinant human tumor necrosis factor-α-related apoptosis inducing ligand (TRAIL), agonistic monoclonal antibodies to TRAIL receptors, and small molecule…”
Get full text

Potential Involvement of the South American Lungfish Intelectin-2 in Innate-Associated Immune Modulation by Bernardes, Gabriela Patrícia Martins de Almeida, Serra, Gustavo Marques, Silva, Lucas da Silva E, Martins, Maíra Pompeu, Perez, Louise Neiva, Molfetta, Fábio Alberto de, Santos, Agenor Valadares, Schneider, Maria Paula Cruz

“…Intelectins belong to a family of lectins with specific and transitory carbohydrate interaction capabilities. These interactions are related to the activity of…”
Get full text